UPMC Physician Resources

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B-cell Lymphomagenesis:A Complex Interplay of Infection, Inflammation, and Chromosomal Translocation

Dr. Linda McAllister-Lucas will discuss B-Cell Lymphoma and how it can arise as a complex interplay of infection, inflammation, and chromosomal translocation.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe how specific infections promote the development of cancer, and more specifically, B-cell lymphoma
  • Describe how analyzing recurrent cytogenetic abnormalities in B-cell lymphoma can provide important prognostic and therapeutic information
  • Recognize how chronic inflammation can be linked to lymphoma development

Reading Resources:

  1. Suarez, F. et al. Blood 2006;107:3034-3044.
  2. Rosebeck S, Rehman AO, Apel IJ, Kohrt D, Appert A, O'Donnell MA, Ting AT, Du MQ, Baens M, Lucas PC, McAllister-Lucas LM. The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling. Oncogene. 2013 Jun 17.
  3. McAllister-Lucas LM, Baens M, Lucas PC. MALT1 protease: a new therapeutic target in B lymphoma and beyond? Clin Cancer Res. 2011 Nov 1;17(21):6623-31.


Dr. McAllister-Lucas has no relevant relationships with proprietary entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 10/1/2013 | Last Modified On: 10/1/2013 | Expires: 10/1/2014



Linda M. McAllister-Lucas, MD, PhD

Linda M. McAllister-Lucas, MD, PhD Chief of Service, Hematology/Oncology
Associate Professor of Pediatrics, University of Pittsburgh School of Medicine
Office Address(es):
4401 Penn Avenue, Floor 9
Pittsburgh, PA 15224
412-692-7693 Fax
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