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Cystic Fibrosis: A Paradigm for Genetics to Personalized Medicine

Dr. Pilewski provides an overview of the clinical features of typical and atypical Cystic Fibrosis, as well as discusses diagnostic criteria, pathogenesis, and genetic mutation based drug therapy.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Improve treatment of patients with respiratory or gastrointestinal disease by recognizing atypical presentations of cystic fibrosis in adults
  • Implement diagnostic skills for making a diagnosis of Cystic Fibrosis
  • Increase outcomes for patients with Cystic Fibrosis by understanding the development of new therapies based on genetics

Reading Resources:

  1. O'Sullivan BP, Freedman SD. Cystic fibrosis.  Lancet. 2009 May 30;373(9678):1891-904.
  2. Sloane PA, Rowe SM.  Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosis.  Curr Opin Pulm Med. 2010 Nov;16(6):591-7.
  3. Stenbit AE, Flume PA.  Pulmonary exacerbations in cystic fibrosis.  Curr Opin Pulm Med. 2011 Nov;17(6):442-7.


Dr. Pilewski has the following financial interests with the following proprietary entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Cystic Fibrosis Foundation, Vertex Pharma, PTC Therapeutics
  • Consultant: Verlex Pharma
  • CE Spearkers' Bureau: Vertex Pharma

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to 0.75 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/22/2012 | Last Modified On: 5/20/2013 | Expires: 5/20/2014



Joseph M. Pilewski, MD

Joseph M. Pilewski, MD Dr. Joseph Pilewski is a native of western Pennsylvania, and joined the PACCM faculty in 1994. He completed undergraduate studies in Philosophy at Holy Cross College in Worcester, MA, and obtained his Doctor of Medicine with honors at the University of Rochester in Rochester, NY. He completed ...
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