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DOM Medical Grand Rounds: The Bench to Bedside: The Future of Pharmacogenomics and Precision Therapeutics

In this presentation, Drs. Dennis McNamara and Philip Empey each present from the department of medicine medical grand rounds. Dr. Mcnamara discusses heart failure in African Americans and provides an overview of the unique epidemiology compared to white counterparts and how medical therapy and pharmacogenetics can be used to improve the distinction. Dr. Philip Empey explains some of the new initiatives going on at the University of Pittsburgh and lays a framework for how more research can be conducted in the future.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Improve the ability to diagnose the etiology of heart failure in African Americans.
  • Improve outcomes by increased utilization of proven heart failure therapies
  • Improve the potential of genomics to target therapy in the future.
  • Describe why pharmacogenomics is a leading use case for precision medicine.
  • Integrate genetic data with clinical variables to guide antiplatelet medication prescribing following percutaneous coronary intervention. 
  • Improve the ability to diagnose the etiology of heart failure in African Americans.
  • Improve outcomes by increased utilization of proven heart failure therapies
  • Recognize the potential of genomics to target therapy in the future 

Reading Resources:

1. Yancy CW. J Card Fail. 2000;6:186.
2. Hare JM. N Engl J Med. 2004;351:2112-2114
3. Carson P, et al. J Card Fail. 1999;5178-187.
4. Rosskopf et al. Hypertension 2000 936) 33-41.
5. McNamara DM, et al. JACC Heart Fail. 2014; 2(6):551-557.
6. Ware JS et al. N Engl J Med 2016;374:233-241.
7. Meyer UA. Nat Rev Genet. 2004;5(9):669-676.
8. Empey et al. Crit Care Med. 38(6):s106-16.
9. Shudliner et al. JAMA 2009;302(8):849-857.
10. Scott et al. CP&T. 2011;90(2):328-32.
11. Kim et al. CP&T. 2008;84(2):236-242.
12. Mega et al. NEJM. 2009;360(4):354-362.
13. Simon et al. NEJM. 2009; 360(4): 363-75.

Disclosures: 

Dr. Empey has reported no relevant relationships with proprietary entities producing health care goods or services.

Dr. Mcnamara has financial interests with the following proprietary entity or entities producing health care goods or services as indicated below: 

  • Grant/Research Support: Arbor Pharmaceutical Co. Provide Drug for GRAH2
  • Consulatant: Sanofi Pharmaceutical, GE Healthcare

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary. 

ABIM MOC Part 2 Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. 

To receive your ABIM MOC Part 2 credit, you will need to complete the post-test and evaluation process and provided your date of birth and ABIM number, along with the other required fields.

Release Date: 2/2/2017 | Last Modified On: 2/2/2017 | Expires: 2/3/2020

Presenters

Dennis M. McNamara, MD

Dennis M. McNamara, MD Dr. Dennis McNamara is a Professor of Medicine, University of Pittsburgh. He is also the Director of the Heart Failure/Transplantation Program at the University of Pittsburgh Medical Center.
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Philip Empey, PharmD, PhD

Philip Empey, PharmD, PhD Assistant Professor, Pharmacy and Therapeutics
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