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Hot Topics in Inflammatory Bowel Disease – 2012

Dr. Miguel Regueiro recent presentation includes a discussion of biological loss of response, deep remission of crohn's disease, and new medications for Inflammatory Bowel Disease (IBD).

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe mechanisms of loss of response to anti-TNF medications and how to manage the loss of response
  • To identify risk factors for postoperative Crohn’s disease recurrence and medications that may be useful in preventing recurrence

Reading Resources:

  1. Cones J, Nion-Larmurier I, Beaugerie L, et al. Impact of increasing use of immunosuppressants in Crohn’s disease on the need for intestinal surgery. Gut 2005;54:237–241.
  2. Bennell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn’s disease. Ann Surg 2000; 231:38–45.
  3. D’Haens G, Geboes K, Peeters M, et al. Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998;114:262–267.
  4. Olaison G, Smedh K, Sjodahl R. Natural course of Crohn’s disease after ileocolic resection: endoscopically visualized ileal ulcers preceding symptoms. Gut 1992;33:331–335.
  5. Rutgeerts P, Geboes K, Vantrappen G, et al. Predictability of the postoperative course of Crohn’s disease. Gastroenterology 1990;99:956–983.
  6. Sachar DB. The problem of postoperative recurrence of Crohn’s disease. Med Clin North Am 1990;74:183–188.
  7. Michelassi F, Balestracci T, Chappel R, et al. Primary and recurrent  Crohn’s disease: experience with 1379 patients. Ann Surg 1991;214:230–240.
  8. Regueiro M, et. al. Infliximab prevents Crohn’s disease recurrence after ileal resection, Gastroenterology 2009;136:441–450.


Dr. Regueiro has financial interests with the following proprietary entity or entities producing health care goods or services:

  • Consultant: Abbott, Axcan, Janssen, johnson and johnson, P&G, Prometheus, Salix, Shire, UCB, and Warner-Chilcott

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.50 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.50 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 11/6/2012 | Last Modified On: 11/6/2012 | Expires: 11/6/2013



Miguel D. Regueiro, MD

Miguel D. Regueiro, MD University of Pittsburgh Physicians
Division of Gastroenterology, Hepatology & Nutrition
Office Address(es):
Digestive Disorders Center
200 Lothrop Street, 3rd Floor
Pittsburgh, PA 15213
Phone: (412) 647-8666
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