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Medication-Induced Diabetes Mellitus

Dr. Griffith provides an overview of three categories of drugs that are associated with an increased prevalence of diabetes, discusses the risk of diabetes mellitus for different agents within each group, and reviews known mechanisms and treatment considerations in this recent CME presentation.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe the mechanism of glucocorticoid-induced hyperglycemia, which will result in greater understanding of the impact of these drugs on the patient’s glycemic control
  • Recognize antipsychotic agents that may be more associated with weight gain and diabetes, in order to improve patient counseling when these drugs are initiated
  • Recognize antiviral agents that may be more associated with diabetes, in order to improve patient counseling when these drugs are initiated

Reading Resources:

  1. van Raalte DH,  Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 2009; 39 (2): 81-93.
  2. Feeney ER and PWG Mallon. Insulin resistance in treated HIV infection. Best Practice & Research Clinical Endocrinology & Metabolism. 2011; 25: 443-458.
  3. Muench J and AM Hamer. Adverse effects of antipsychotic medications. American Family Physician 2010; 81(5):617-22.


Dr. Griffith has no relevant relationships with proprietary entities producing healthcare goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/8/2012 | Last Modified On: 5/20/2012 | Expires: 5/20/2014



Michelle L Griffith, MD

Michelle L Griffith, MD Michelle L. Griffith, MD, is an endocrinologist with UPMC’s Center for Diabetes and Endocrinology, as well as a clinical assistant professor of medicine in the Division of Endocrinology and Metabolism, at the University of Pittsburgh School of Medicine.
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