Drs. Anuradha Ray and Jay Kolls each present from the 2016
Pitt-Munich International Lung Conference. Dr. Ray discusses Immune Tolerance
in Maintenance of Lung Heath and Loss in Disease and Dr. Kolls discusses Type17
Cells and Defense against Lung Pathogens.
Educational objectives:
Upon completion of this activity, participants should be
able to:
- Recognize that immune mechanisms, both positive and
negative, impact respiratory health.
- Recognize the role of mitochondrial H2O2
as a negative regulator of inflammation in the face of constant provocation of
the respiratory tract by environmental agents.
- Identify a role of the cytokine interferon gamma (IFN-g) in severe asthma.
- Review primary genetic mutations that confer increases risk
of fungal pneumonia.
- Review mechanisms by which primary genetic mutations that
confer increases risk of fungal pneumonia
- Review how IL-22 has in vivo anti-fungal activity in pre-clinical
models of fungal pneumonia
Reading Resources:
- Khare, A., Raundhal, M., Chakraborty, K., Das, S., Corey,
C., Kamga, CK, Quesnelle, K., St. Croix, C., Watkins, S.C., Morse, C., Oriss,
T.B., Huff, R., Hannum, R., Ray, P, Shiva, S., Ray, A. (2016) Mitochondrial
H2O2 in lung antigen-presenting cells blocks NF-?B activation to block
unwarranted immune activation. Cell Reports 15:1700-1714.
- Raundhal, M., Morse, M., Khare, A., Oriss, T.B.,
Milosevic, J., Trudeau, J., Huff, R., Pilewski, J., Holguin, F., Kolls, J.
Wenzel, S.E., Ray, P. ¶,, Ray, A. ¶, (2015) High IFN-? and Low SLPI Mark Severe Asthma In Humans and Mice.
J. Clin. Invest. 125:3037-3050. PMID: 26121748. ¶,-co-senior authors.
- Ray, A., Raundhal, M., Oriss, T.B., Ray, P., Ray, A.
(2016) Current concepts of severe asthma. J. Clin. Invest. 126:2394-2403.
- Arian Laurence, John J O'Shea & Wendy T Watford, Nature Medicine 14, 247 - 249 (2008)
- CI Insight.
2016 Jul 21;1(11). pii: e87168.
Disclosures:
Dr. Ray has reported no relevant relationships with
any entities producing health care goods or services
Dr. Kolls has financial interests with the following
any entity or entities producing health care goods or services as
indicated below:
- Grant/Research Support: Grants from NHLBI and NIAID
- Consultant: Boehringer - Ingelheim, Vitae
All presenters disclosure of relevant financial
relationships with any entity producing, marketing, re-selling, or
distributing health care goods or services, used on, or consumed by, patients
is listed above. No other planners,
members of the planning committee, speakers, presenters, authors, content
reviewers and/or anyone else in a position to control the content of this
education activity have relevant financial relationships to disclose.
Accreditation Statement:
The University of Pittsburgh School of Medicine is
accredited by the Accreditation Council for Continuing Medical Education
(ACCME) to provide continuing medical education for physicians.
The University of Pittsburgh School of Medicine designates
this enduring material for a maximum of .75 AMA PRA Category 1
Credits™. Each physician should only claim credit commensurate with
the extent of their participation in the activity. Other health care
professionals are awarded (0.075) continuing education units (CEU) which are
equivalent to .75 contact hour.
For your credit transcript, please access our website 4 weeks
post-completion at http://ccehs.upmc.edu and follow the link to the Credit
Transcript page. If you do not provide the last 5 digits of your SSN on the
next page you will not be able to access a CME credit transcript. Providing
your SSN is voluntary.
Release Date: 1/31/2017 | Last Modified On: 1/31/2017 |
Expires: 1/31/2018
