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Selected Presentations from the 2012 Pittsburgh International Lung Conference

Three specialists give presentations on role of blood product support in lung injury, role of lung MDSC-like cells in resolution of bacterial pneumonia, and lipidomic damage signals and the ubiquitin E3 ligase system.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Identify constituents of red cell breakdown as potential biological response modifiers
  • Identify endogenous protective mechanisms that mitigates cytotoxic, oxidative, and inflammatory components of red cell breakdown
  • Examine susceptibility factors that predispose the host to the development of lung injury
  • Describe lung cells that increase in numbers in response to bacterial infection to regulate lung inflammation
  • Define the role of lung myeloid cells in removing dead neutrophils after infection
  • Discuss the importance of the above process, including the function of IL-10
  • Identify lipidomic lung damage signals in acute lung injury
  • Identify components of the ubiquitin proteasome machinery in lung injury
  • Identify novel therapeutics in preclinical models of acute lung injury

Reading Resources:

  1. Muller-Eberhard, U., Javid, J., Liem, H.H., Hanstein, A. & Hanna, M. Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood 32, 811-815 (1968).
  2. Gong, M.N., et al. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med 33, 1191-1198 (2005).
  3. Fowler, A.A., et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med 98, 593-597 (1983).
  4. Poe et al., Mucosal Immunol. doi: 10.1038/mi.2012.62.
  5. Loanas et al., Eur Respir J 22:876, 2003.
  6. Ebraham, E., Crit Care Med. 2003
  7. *Ray, N.B., Durairaj L, Chen B.B., Mcverry, B.J., Ryan, A.J., Donahoe, M., Waltenbaugh, A.K., O'Donnell, C.P.,Henderson, F.C., Etscheidt, C., McCoy, D., Agassandian, M., Hayes-Rowan, E., Coon, T.A., Butler, T.L., Gakhar, L., Mathur, S.N., Sieren, J. C., Tyurina, Y.Y., Kagan, V.E., McLennan, G., and Mallampalli, R.K. Dynamic regulation of cardiolipin by the lipid pump, ATP8b1, determines the severity of lung injury in experimental pneumonia. Not. Med. 1621120-27, 2010.
  8. Chen, B.B. Coon, T.A., Glasser, J.R., and Mallampalli, R.K. Calmodulin antagonizes a calcium-activated SCF ubiquitin E3ligase subunit, FBXi.2, to regulate surfactant homeostasis. Mal.Cell. Biol. 31: 1905-1920, 2013..
  9. Zhao 1., Wei J., Mialki R.K., Chen B.B., Coon C., Zou C., *Mal|ampaIli R.K., *Zhao Y. F-box protein FBXL19-mediated ubiquitination and degradation of the IL~33 receptor limits pulmonary inflammation. Nat. lmmunol. 13(7), 651-658 2012.

Disclosures:

Dr. Lee has financial interests with the following proprietary entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIH

Dr. Ray has financial interests with the following proprietary entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIH

Dr. Mallampalli has financial interests with the following proprietary entity or entities producing health care goods or services as indicated below:

  • GrantlResearch Support: NIH and Dept. of Veterans Affairs

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/13/2013 | Last Modified On: 2/13/2013 | Expires: 2/13/2014

Presenters

Janet S. Lee, MD

Janet S. Lee, MD Office Address(es):
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2210
Fax: 412-692-2260
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Prabir Ray, PhD

Prabir Ray, PhD Office Address(es):
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2118
Fax: 412-692-2
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Rama K. Mallampalli, MD

Rama K. Mallampalli, MD Office Address(es):
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-6247-8735
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