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Why Enteral Feeding Shortens SIRS and Decreases Infections

Dr. Stephen O'Keefe examines the role of enteral feeding in reducing systemic inflammatory response and infections during patient hospitalization.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Examine the importance of the gut in the mediation of the systemic inflammatory response
  • Demonstrate how enteral feeding can suppress the systemic inflammatory response in critical illness
  • Explain why enteral feeding reduces infections

Reading Resources:

  1. Early jejunal feeding initiation and clinical outcomes in patients with severe acute pancreatitis. Hegazi R, Raina A, Graham T, Rolniak S, Centa P, Kandil H, O'Keefe SJ. JPEN J Parenter Enteral Nutr. 2011 Jan;35(1):91-6. Erratum in: JPEN J Parenter Enteral Nutr. 2011 Mar;35(2):276.
  2. Tube feeding, the microbiota, and Clostridium difficile infection. O'Keefe SJ. World J Gastroenterol. 2010 Jan 14;16(2):139-42. Review.
  3. A guide to enteral access procedures and enteral nutrition. O'Keefe SJ. Nat Rev Gastroenterol Hepatol. 2009 Apr;6(4):207-15. Review.


Dr. O'Keefe serves on the advisory board and is a consultant for NPS Pharmaceuticals.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .05 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 12/26/2012 | Last Modified On: 12/26/2012 | Expires: 12/26/2013

Additional Resources


Stephen J. O'Keefe, MD

Stephen J. O'Keefe, MD Dr O’Keefe’s research is in the field of nutritional gastroenterology. Most of his investigations are translational in nature, evaluating the physiological and pathophysiological responses to dietary intake and interventional feeding. He has had NIH funding for his studies on the effects of ...
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