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Director, Richard King Mellon Foundation Institute for Pediatric Research Professor of Pediatrics and Immunology, University of Pittsburgh School of Medicine Vice Chair for Translational Research Interim NIH T32 Program Director, Division of Pediatric Rheumatology
Specialty:
Internal Medicine
Pediatric Pulmonology
Pulmonology
Pediatrics
Pediatric Pulmonology
Internal Medicine
MD, University of Maryland School of Medicine Baltimore, MD
Louisiana State University Health Sciences Center
New Orleans, LA
Louisiana State University Health Sciences Center
New Orleans, LA
Children's Hospital of Pittsburgh of UPMC
The major goal of Dr. Kolls' research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. Presently, he is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. To this end, he studies cellular sources of IL-17A, IL-17F, and IL-22 in the lung and liver as well as their signaling in response to pulmonary infection or hepatitis.
Dr. Kolls also has a long standing interest to determine if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis. He also has a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer. In these studies, he has identified that sub-populations of CD8+ T-cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii.
Dr. Kolls is presently using gene expression profiling and proteomics to define this effector activity. He also has a program in developing CD4-independent vaccination against AIDS-related opportunistic infections.