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Drs. Janet S. Lee and John McDyer each present from the 2016 Pitt-Munich International Lung Conference. Dr. Lee discusses enhancing host defenses to counter MDR gram-negative bacterial pneumonias and Dr. McDyer discusses targeting immune pathways with small molecule inhibitors to block lung transplant rejection. 

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Identify burden of infection and risk factors for increased mortality in patients in Intensive Care Units.
  • Define sepsis in order to better identify patients with this syndrome.
  • Define acute respiratory distress syndrome (ARDS) in order to better identify patients with this syndrome
  • Recognize the challenges of lung transplant
  • Recognize the role of ubiquitination in lung transplant
  • Recognize the pathways involved in lung rejection

Reading Resources: 

  1. Ferguson, N.D., Fan, E., Camporota, L., Antonelli, M., Anzueto, A., Beale, R., Brochard, L., Brower, R., Esteban, A., Gattinoni, L., Rhodes, A., Slutsky, A.S., Vincent, J.-L., Rubenfeld, G.D., Thompson, B.T. and Ranieri, V.M. 2012. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Medicine 38(10), pp. 1573–1582.
  2. Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G.R., Chiche, J.-D., Coopersmith, C.M., Hotchkiss, R.S., Levy, M.M., Marshall, J.C., Martin, G.S., Opal, S.M., Rubenfeld, G.D., van der Poll, T., Vincent, J.-L. and Angus, D.C. 2016. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The Journal of the American Medical Association 315(8), pp. 801–810.
  3. Stapleton, R.D., Wang, B.M., Hudson, L.D., Rubenfeld, G.D., Caldwell, E.S. and Steinberg, K.P. 2005. Causes and timing of death in patients with ARDS. Chest 128(2), pp. 525–532. 
  4. Vincent, J.-L., Rello, J., Marshall, J., Silva, E., Anzueto, A., Martin, C.D., Moreno, R., Lipman, J., Gomersall, C., Sakr, Y., Reinhart, K. and EPIC II Group of Investigators 2009. International study of the prevalence and outcomes of infection in intensive care units. The Journal of the American Medical Association 302(21), pp. 2323–2329.
  5. Dodd-o JM, Lendermon EA, Miller H, Zhong Q, John ER, Jungraithmayr WM, and McDyer JF: CD154 Blockade Abrogates Allospecific Responses and Enhances CD4+ Regulatory T Cells in Orthotopic Lung Transplant.  American Journal of Transplantation, 2011, 11 (9): 1815-24. PMCID: 21827610.
  6. Chen BB, Coon TA, Glasser JR, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nature immunology 2013;14:470-9.
  7. Chen BB, Glasser JR, Coon TA, Mallampalli RK. FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest. Cell Cycle 2011;10:3487-94.


Dr. lee has financial interests with the following any entity or entities producing health care goods or services as indicated below: 

  • Grant/Research Support: NIH, Cystic Fibrosis Foundation

Dr. McDyer has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Onyx/Amgen, PI for investigator-initiated study of Carfilzomib for lung transplant projection.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/7/2017 | Last Modified On: 2/7/2017 | Expires: 2/7/2018

This course has been expired.