Dr. Robert Squires reviews the history, diagnosis, and studies
for acute liver failure in children.
Upon completion of this activity, participants should be
that hepatic encephalopathy is not a required to establish a diagnosis of acute
liver failure in children.
- Recognize the results of the
randomized trial of N-acetylcysteine (NAC) in children with acute liver failure
not caused by acetaminophen.
- Recognize that the liver is an
immunological solid organ
- Squires RH, Shneider BL, Bucuvalas
J, Alonso E, Sokol RJ, Narkewicz MR, Dhawan A, Rosenthal P, Rodriguez-Baez N,
Murray KF, Horslen S, Martin MG, Lopez MJ, Soriano H, McGuire BM, Jonas MM,
Yazigi N, Shepherd RW, Schwarz K, Lobritto S, Thomas DW, Lavine JE, Karpen S,
Ng V, Kelly D, Simonds N, Hynan LS.
Acute Liver Failure in Children: The First 348 Patients in the Pediatric
Acute Liver Failure Study Group. J.
- Squires RH. Acute Liver Failure in Children. Seminars in Liver Disease. 2008;28:153-166.
- Narkewicz MR, Dell-Olio D, Karpen
SJ, Murray KF, Schwarz K, Yazigi N, Zhang S, Belle SH, Squires RH. Pattern of diagnostic evaluation for the
causes of pediatric acute liver failure.
J Pediatrics 2009; 155:801-806.
PMID: 19643443 PMCID: N/A
- Sundaram SS, Alonso EM, Narkewicz
M, Zhang S, Squires R, and the PALF Study Group. Characterization and outcomes
of young infants with acute liver failure. J Pediatr 2011;159(5):813-18. PMCID: PMC3177978
- Squires RH, Dhawan A, Alonso E,
Narkewicz MR, Shneider BL, Rodriguez-Baez N, Dell Olio D, Karpen S, Bucuvalas
J, Lobritto S, Rand R, Rosenthal P, Horslen S, Ng V, Subbaro G, Kerkar N,
Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor
S, Belle SH for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric
patients with non-acetaminophen acute liver failure: A placebo-controlled
trial. Hepatology. 2013:57;1542-49. (PMC3509266)
- Azhar N, Ziraldo C, Barclay D,
Rudnick D, Squires RH, Vodovotz Y for the Pediatric Acute Liver Failure Study
Group. Analysis of serum inflammatory
mediators identifies unique dynamic networks associated with death and
spontaneous survival in pediatric acute liver failure. PLOS ONE.
- Li R, Belle SH, Horslen S, Chen
LW, Zhang S, Squires RH. Clinical course
among pediatric cases of acute liver failure of indeterminate diagnosis. J
Pediatr 2016;171:163-170. (PMC 4808594)
Dr. Squires has reported no relevant relationships with
any entities producing health care goods or services.
All presenters disclosure of relevant financial
relationships with any any entity producing, marketing, re-selling, or
distributing health care goods or services, used on, or consumed by, patients
is listed above. No other planners,
members of the planning committee, speakers, presenters, authors, content
reviewers and/or anyone else in a position to control the content of this
education activity have relevant financial relationships to disclose.
The University of Pittsburgh School of Medicine is
accredited by the Accreditation Council for Continuing Medical Education
(ACCME) to provide continuing medical education for physicians.
The University of Pittsburgh School of Medicine designates
this enduring material for a maximum of .75 AMA PRA Category 1
Credits™. Each physician should only claim credit commensurate with
the extent of their participation in the activity. Other health care
professionals are awarded (0.075) continuing education units (CEU) which are
equivalent to .75 contact hour.
For your credit transcript, please access our website 4
weeks post-completion at http://ccehs.upmc.edu and follow the link to the
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Release Date: 6/21/2016 | Last Modified On: 6/21/2016 |