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Drs. Larry Moreland and Mandy McGeachy each present in this medical grand rounds presentation. Dr. Moreland focuses his presentation on Joint Ventures in Rheumatoid Arthritis—Aiming For a Cure and Dr. McGeachy discusses Inflammatory T helper cells in context of RA disease activity and therapy.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Review the pathogenesis of RA
  • Identify the clinical spectrum of RA
  • Evaluate the therapeutic options for RA
  • Describe the role of Th17 in pathogenesis of RA

Reading Resources:

  1. Winthrop KL. Rheum Dis Clin N Am. 2012;38:727-745
  2. Plant, D. et al. (2014) Genetic and epigenetic predictors of responsiveness to treatment in RA
  3. Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.16
  4. Ann Rheum Dis 2010;69:2062-2066
  5. Nature 2012; 490:102-106
  6. Nature Reviews Immunology 2013;13:23-33
  7. J Immunology 2013;190:2650-2658


Dr. McGeachy has reported no relevant relationships with any entities producing health care goods or services.

Dr. Moreland has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Genentech, Pfizer, Questcor, Roche, Bristol Myers Squibb
  • Consultant: Pfizer, Boehringer Ingelheim, Acerta, Genentech, CVS / Caremark

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to .75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/29/2016 | Last Modified On: 2/29/2016 | Expires: 3/1/2017

This course has been expired.