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In this presentation, Dr. David Whitcomb provides a brief overview of the clinical manifestations and biology of Cystic Fibrosis, as well as Cystic Fibrosis of the pancreas.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Recognize the role of CFTR in human biology
  • Recognize the effects of CFTR gene variance on human health
  • Apply new advances in genetics into clinical practice

Reading Resources:

  1. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med. 1998;339(10):653-8. PMID: 9725922
  2. Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. New England Journal of Medicine. 1998;339(10):645-52


Dr. Whitcomb has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIH, DOD, AbbVie, National Pancreas Foundation
  • Consultant: AbbVie, Novartis
  • Stockholder: SMART-MD, Ambry Genetics

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to .75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 9/10/2015 | Last Modified On: 9/10/2015 | Expires: 9/12/2016

This course has been expired.