Mechanistic Insights and Clinical Implications from Genetic Studies of Cardiomyopathies

Dr. Ahmad discusses hypertrophic cardiomyopathy (HCM), HCM mimickers, dilated cardiomyopathy (DLM), arrythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/ARVD), and others in this pediatric grand rounds presentation.

Educational objectives:

Upon completion of this activity, participants should be able to:

• Identify the clinical presentation and course of the major heritable cardiomyopathies
• Describe the underlying genetic basis of these cardiomyopathies
• Discuss the current understanding of the mechanisms of cardiomyopathic remodeling

Reading Resources:

1. The Genetic Basis for Cardiac Remodeling. Ferhaan Ahmad,  J.G. Seidman, and Christine E. Seidman. Annu. Rev. Genomics Hum. Genet. 2005. 6:185–216.
2. Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline. Ray E. Hershberger, MD, Joann Lindenfeld, MD, Luisa Mestroni, MD, Christine E. Seidman, MD, Matthew R.G. Taylor, MD, PhD, and Jeffrey A. Towbin, MD. Journal of Cardiac Failure Vol. 15 No. 2 2009.
3. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary : A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Bernard J. Gersh, Barry J. Maron, Robert O. Bonow, Joseph A. Dearani, Michael A., Fifer, Mark S. Link, Srihari S. Naidu, Rick A. Nishimura, Steve R. Ommen, Harry Rakowski, Christine E. Seidman, Jeffrey A. Towbin, James E. Udelson and Clyde W. Yancy. Circulation. November. 2011.

Disclosures:

Dr. Ahmad has no relevant relationships with any entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits^TM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 12/13/2012 | Last Modified On: 12/13/2012 | Expires: 12/13/2013