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Drs. Hassane Zarour and John Kirkwood join together to present from the 2015 Melanoma symposium. These experts focus their presentations on Immunotherapy and melanoma as a paradigm for cancer treatment.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Identify the most effective regimens for advanced melanoma in 2015 and the current strategies for improving upon these results in phase II-III trials.
  • Identify the actual mechanisms of immune checkpoint blockade as immunotherapy of melanoma.
  • Identify and correlate auto-immune side effects of immune checkpoint blockade and the development of biomarker driven studies to improve the application of new therapies to patients with melanoma.

Reading Resources:

  1. Immunotherapy of cancer in 2012. Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P, Ferrone S. CA Cancer J Clin. 2012 Sep-Oct;62(5):309-35. doi: 10.3322/caac.20132. Epub 2012 May 10. Review
  2. Strategies to reverse melanoma-induced T-cell dysfunction. Fourcade J, Zarour HM. Clin Dermatol. 2013 May-Jun;31(3):251-6. doi: 10.1016/j.clindermatol.2012.08.010. PMID: 23608444 Free PMC Article
  3. New therapies in the treatment of melanoma. Davar D, Kirkwood JM. Expert Opin Investig Drugs. 2012 Nov;21(11):1643-59. doi: 10.1517/13543784.2012.713938. Epub 2012 Aug 9. Review. PMID: 22876817


Dr. Zarour has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/ Research Support: Bristol-Myers Squibb and Merck

Dr. Kirkwood has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Prometheus, Inc.
  • Consultant: BMS, GSK, Merck

 Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/3/16 | Last Modified On: 2/3/16 | Expires: 2/3/17

This course has been expired.