Drs. Anuradha Ray and Sally Wenzel present on asthma treatment, focusing on immunology and precision medicine.
Upon completion of this activity, participants should be
- Explain the development of the concept of a Type-2 asthma
phenotype (from bench to bedside)
- Review the data on development and use of Type-2 targeted therapies for asthma
- Address the underlying pathobiology and potential treatment
pathways in very severe, corticosteroid dependent asthma, beyond Type-2
- Gauthier M, Ray A, Wenzel SE. Evolving Concepts of
Asthma. Am J Respir Crit Care Med. 2015 192:660-8. doi: 10.1164/rccm.201504-0763PP.
PubMed PMID: 26161792.
- Wenzel SE. Asthma phenotypes: the evolution from clinical
to molecular approaches. Nat Med. 2012, 18:716-25. doi: 10.1038/nm.2678.
Review. PubMed PMID: 22561835.
- Raundhal M, Morse C, Khare A, Oriss TB, Milosevic J,
Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A. High
IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015,
125:3037-50. doi: 10.1172/JCI80911. PubMed PMID: 26121748
- Wenzel S, Ford L, Pearlman D, Spector S, Sher L,
Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin
A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G. Dupilumab in persistent
asthma with elevated eosinophil levels. N Engl J Med. 2013, 368:2455-66. doi: 10.1056/NEJMoa1304048. PubMed PMID: 23688323.
- Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald
JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P; MENSA
Investigators. Mepolizumab treatment in patients with severe eosinophilic asthma. N
Engl J Med. 2014, 371:1198-207. doi: 10.1056/NEJMoa1403290. Erratum in: N Engl J Med. 2015, 372:1777. PubMed PMID: 25199059.
- Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM,
Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, Zeitvogel J, Zhang N, Bille
J, Homburg U, Turowska A, Bachert C, Werfel T, Buhl R, Renz J, Garn H,
Renz H. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N
Engl J Med. 2015, 372:1987-95. doi: 10.1056/NEJMoa1411776.PubMed PMID: 25981191.
- Zhang, D. -H., Cohn, L., Ray, P., Bottomly, K., Ray,
A. Transcription factor GATA-3 is
differentially expressed in Th1 and Th2 cells and controls Th2-specific
expression of the interleukin-5 gene J. Biol. Chem. 1997, 272: 21597-603.
Dr. Ray has reported no relevant relationships with
any entities producing health care goods or services
Dr. Wenzel has financial interests with the following
any entity or entities producing health care goods or services as
- Grant/Research Support: AstraZeneca, GSK, Sanofi, Genentech,
- Consultant: AstraZeneca, GSK, Boehringer-lngelheim,
The University of Pittsburgh School of Medicine is
accredited by the Accreditation Council for Continuing Medical Education
(ACCME) to provide continuing medical education for physicians.
The University of Pittsburgh School of Medicine designates
this enduring material for a maximum of 1 AMA PRA Category 1 Credits™.
Each physician should only claim credit commensurate with the extent of their
participation in the activity. Other health care professionals are awarded
(0.1) continuing education units (CEU) which are equivalent to 1 contact hour.
For your credit transcript, please access our website 4
weeks post-completion at http://ccehs.upmc.edu and follow the link to the
Credit Transcript page. If you do not provide the last 5 digits of your SSN on
the next page you will not be able to access a CME credit transcript. Providing
your SSN is voluntary.
Release Date: 1/4/16 | Last Modified On:
1/4/16 | Expires: 1/4/17