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Dr. J. Timothy Greenamyre discusses the role of mitochondria in PD pathogenesis, neuroprotective strategies that converge on mitochondria, and development of a mitochondrial biomarker that may enable drug development. 

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe the role of genetics in Parkinson’s disease.
  • Discuss the role of environmental factors in Parkinson’s disease.
  • Discuss recent research about the role of rotenone and implications for future studies.

Reading Resources:

  1. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci. 2000;3:1301-6. 
  2. Schneider SA, Obeso JA. Clinical and Pathological Features of Parkinson's Disease. Current topics in behavioral neurosciences. 2014.
  3. Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson's disease: progress and therapeutic implications. Mov Disord. 2013;28:14-23.


Dr. Greenamyre has reported no relevant relationships with any entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 6/18/2015 | Last Modified On: 6/18/2015 | Expires: 6/20/2016

This course has been expired.