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In this issue of Neurosurgery News, several specialists join together to discuss the evolutions of the gamma knife at UPMC, trigeminal neuralgia radiosurgery, gamma knife radiosurgery for arteriovenous malformations, stereotactic radiosurgery for tremor, when cancer spreads to the Brain, and gamma knife radiosurgery for vestibular schwannomas and meningiomas.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Define the role of radiosurgery in the management of tremor.
  • Review Meningioma tumor control rates with Gamma knife
  • Define the role of radiosurgery in the management of trigeminal neuralgia.

Reading Resources:

  1. Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G.  Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.  JAMA. 2006 Jun 7;295(21):2483-91.
  2. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA.  Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial.  Lancet Oncol. 2009 Nov;10(11):1037-44. doi: 10.1016/S1470-2045(09)70263-3. Epub 2009 Oct 2.
  3. Monaco EA 3rd, Faraji AH, Berkowitz O, Parry PV, Hadelsberg U, Kano H, Niranjan A, Kondziolka D, Lunsford LD. Leukoencephalopathy after whole-brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer. Cancer. 2013 Jan 1;119(1):226-32. doi: 10.1002/cncr.27504. Epub 2012 Jun 15.


Greg Bowden, MD, Edward A. Monaco III, MD, PhD, Ajay Niranjan, MD, MBA, and Svetlana Trofimova, MS, PA-C, have reported no relationships with any entities producing health care goods or services.

L. Dade Lunsford, MD, is a consultant for AB Elekta and Insightec DSMB. Dr. Lunsford is a stockholder in AB Elekta.

Hideyuki Kano, MD, PhD, receives grant research support from Elekta.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/25/2016 | Last Modified On: 2/25/2016 | Expires: 2/27/2017

This course has been expired.