This issue presents a case study of traumatic brain injury (TBI)
and post-traumatic seizures (PTS), including a discussion of risk factors,
recognition, and treatment of seizures after TBI.
completion of this activity, participants should be able to:
- Demonstrate understanding of the
potential risk factors for seizures after traumatic brain injury
- Discuss different experimental
models of traumatic brain injury and their findings related to the
proposed relationships between cellular mechanisms and post-traumatic
- Review seizure prophylaxis
guidelines after traumatic brain injury
- Review potential treatments for
- CDC 1: Centers for Disease
Control and Prevention (2014). Traumatic Brain Injury in the United States:
Fact Sheet. Retrieved 2014 from Centers for Disease Control and Prevention.
- CDC 2: Centers for Disease
Control and Prevention (2014). Severe Traumatic Brain Injury. Retrieved 2014
from Centers for Disease Control and Prevention.
- Englander J, Cifu DX,
Diaz-Arrastia R (2014). Seizures After Traumatic Brain Injury. Archives of
Physical Medicine and Rehabilitation, 95, 1223-1224.
- Hesdorffer DC, Benn EKT,
Cascino GD, Hauser WA (2009). Is a First Acute Symptomatic Seizure Epilepsy?
Mortality and Risk for Recurrent Seizure. Epilepsia, 50 (5): 1102-1108.
- Fisher RS, Acevedo C,
Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel Jr. J, Forsgren L, French
JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer
IE, Tomson T, Watanabe M, Wiebe S (2014). A Practical Clinical Definition of
Epilepsy. Epilepsia, 55(4): 475-482.
- Rao VR, Parko KL (2015).
Clinical Approach to Posttraumatic Epilepsy. Semin Neurol, 35: 57-63.
- Annegers JF, Hauser WA,
Coan SP, Rocca WA (1998). A Population-Based Study of Seizures After Traumatic
Brain Injuries. NEJM, 338: 20-24.
- Englander J, Bushnik T,
Duong TT, Cifu DX, Zafonte R, Wright J, Hughes R, Bergman W (2003). Analyzing
Risk Factors for Late Postraumatic Seizures: A Prospective, Multicenter
Investigation. Arch Phys Med Rehabil, 84: 365-373.
- Al-Haddad SA, Kirollos R
(2002). A 5-Year Study of the Outcome of Surgically Treated Depressed Skull
Fractures. Ann R Coll Surg Engl, 84: 196-200.
- Frey LC (2003).
Epidemiology of Posttraumatic Epilepsy: A Critical Review. Epilepsia, 44
(Suppl. 10): 11-17.
Galang, Ferimer, and Wagner have reported no relevant relationships with
any entities producing health care goods or services.
University of Pittsburgh School of Medicine is accredited by the Accreditation
Council for Continuing Medical Education (ACCME) to provide continuing medical
education for physicians.
University of Pittsburgh School of Medicine designates this enduring material
for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only
claim credit commensurate with the extent of their participation in the
activity. Other health care professionals are awarded (0.05) continuing
education units (CEU) which are equivalent to .5 contact hour.
credit transcript, please access our website 4 weeks post-completion at
http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you
do not provide the last 5 digits of your SSN on the next page you will not be
able to access a CME credit transcript. Providing your SSN is voluntary.
Date: 8/21/2015 | Last Modified On: 8/21/2015 | Expires: 8/22/2016