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In the recent release of Rheumatology Grand Rounds, Dr. Kimberly P. Liang provides an overview of Systemic Lupus Erythematosus, its criteria for diagnosis, the latest treatment approaches and results from recent clinical trials.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe the clinical manifestations and laboratory findings included in making a diagnosis of systemic lupus erythematosus (SLE)
  • Discuss the importance of B cells in the pathophysiology of SLE
  • Name the five B-cell therapies that have been or are still being studied in clinical trials of SLE
  • Describe the conflicting study data that exists on the use of rituximab in SLE
  • List the study populations, trial designs, and outcomes of the various studies of B-cell therapies in SLE

Reading Resources:

  1. Schur PH WD. Diagnosis and differential diagnosis of systemic lupus erythematosus in adults. UpToDate 2011.
  2. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.
  3. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271-7.


Dr. Liang has no relevant relationships with any entities producing healthcare goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/28/2012 | Last Modified On: 9/8/2014 | Expires: 9/8/2015

This course has been expired.