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In this issue of Rheumatology Grand Rounds, Drs. Siamak Moghadam-Kia, Rohit Aggarwal, and Chester Oddis review the clinical features, epidemiology, pathogenesis, genetic risk factors, approaches and management of Statin Myopathies.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Improve approach to statin myopathy by obtaining appropriate laboratory testing prior to initiation of statins
  • Improve IMNM patient outcomes by implementing appropriate therapeutic agents.

Reading Resources:

  1. Mammen AL, Chung T, Christopher-Stine L, Ret al. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011;63(3):713-21.
  2. Christopher-Stine L., Casciola-Rosen L.A., Hong G., et al: A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum 2010; 62: 2757-2766.
  3. Ramanathan S, Langguth D, Hardy TA, et al. Clinical course and treatment of anti-HMGCR antibody-associated necrotizing autoimmune myopathy. Neurol Neuroimmunol Neuroinflamm. 2015;2:e96.


Doctor Moghadam-Kia reports no relevant relationships with any entities producing health care goods and services.

Doctor Oddis receives research support from Genentech and is a consultand for Mallinckrodt.

Doctor Aggarwal receives research support from Pfizer, Mallinckrodt, BMS, Octapharma, and Idera, and serves as a consultant for Mallinckrodt, BMS, and Octapharma.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 12/27/2016 | Last Modified On: 12/27/2016 | Expires: 12/27/2017

This course has been expired.