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Dr. Sciurba provides an overview of the variations of COPD. Explanations for such variations and how they affect patient selection for clinical trials is also discussed.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Define the clinical, radiographic, and physiologic variation within the traditionally defined syndrome of COPD
  • Discuss the genetic, molecular, or environmental reason for the variations
  • Recognize how disease variation may influence patient selection for clinical trials aiming toward development of new devices and pharmacological interventions targeting specific subgroups

Reading Resources:

  1. Endothelial chronic destructive pulmonary disease (E-CDPD): is endothelial apoptosis a subphenotype or prequel to COPD? Chandra D, Sciurba FC, Gladwin MT. Am J Respir Crit Care Med. 2011 Jul 15;184(2):153-5
  2. A new perspective on optimal care for patients with COPD. Postma D, Anzueto A, Calverley P, Jenkins C, Make BJ, Sciurba FC, Similowski T, van der Molen T, Eriksson G. Prim Care Respir J. 2011 Jun;20(2):205-9.
  3. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, Macnee W, Make BJ, Rabe KF, Rennard SI, Sciurba FC, Silverman EK, Vestbo J, Washko GR, Wouters EF, Martinez FJ. Am J Respir Crit Care Med. 2010 Sep 1;182(5):598-604.


Dr. Sciurba has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIH

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/29/2012 | Last Modified On: 3/29/2012 | Expires: 3/28/2013

This course has been expired.