UPMC Physician Resources

Take the CME Evaluation

Biology of Gender  

Dr. Selma Witchel discusses gender dysphoria, treatment interventions, and reviews components of the gender affirmative model.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Recognize and define gender dysphoria
  • Recognize the rationale for use of hormone blockers at the onset of puberty
  • Review components of a gender affirmative model

Reading Resources:

  1. Rosenthal SM. Transgender youth: current concepts. Ann Pediatr Endocrinol Metab. 2016;21(4):185-192.
  2. Reisner SL, Greytak EA, Parsons JT, Ybarra ML.Gender minority social stress in adolescence: disparities in adolescent bullying and substance use by gender identity. J Sex Res. 2015;52(3):243-56.
  3. de Vries AL, Klink D, Cohen-Kettenis PT. What the Primary Care Pediatrician Needs to Know About Gender Incongruence and Gender Dysphoria in Children and Adolescents. Pediatr Clin North Am. 2016;63(6):1121-1135
  4. de Vries AL, McGuire JK, Steensma TD, Wagenaar EC, Doreleijers TA, Cohen-Kettenis PT. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics. 2014;134(4):696-704.


Dr. Witchel has reported no relevant relationships with proprietary entities producing health care goods or services.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to .75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 9/14/2017 | Last Modified On: 9/14/2017 | Expires: 9/14/2018


Selma Witchel, MD

Selma Witchel, MD Director, Pediatric Endocrinology, Fellowship Training Program, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh Associate Professor with Tenure, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh
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