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Central Nervous System Diseases and Altered Gut Function: Mechanisms and Medicines

Dr. Levinthal reviews the impact of CNS dysfunction on the GI system, and the practical approach to diagnosis and management of oropharyngeal dysphagia, constipation and fecal incontinence.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Identify the most common gastrointestinal symptoms seen in patients with underlying neurological illness that affect the central nervous system
  • Adopt a practical approach to the diagnosis and intial management of oropharyngeal dysphagia and anorectal dysfunction in patients with neurological illnesses

Reading Resources:

  1. kalf et al. (2012) Parkinsonism and Related Disorders 18:311-315
  2. Pfeiffer RF (2011) Parkinsonism and Related Disorders 17:10-15
  3. Crary et al.(2006) J. Stroke Cerebrovasc. Dis. 15:164-171
  4. Su et al. (2009) Stroke 40:1304-1309
  5. Brittain et al. (2006) J Am Geriatr Soc 54:1915-1919
  6. Poorjavad et al. (2010) Multiple Sclerosis 16:362-365
  7. Nusrat et al. (2012) ISRN Neurology ID:376023
  8. Abel et al. (2004) Dysphagia 19:87-94
  9. De Looze et al. (1998) Spinal Cord 36:63-66
  10. Ng et al. (2005) Dis Colon Rectum 48:1562-1568
  11. Hamdy S and Rothwell JC (1998) Trends Neurosci. 21(7):278-82


Dr. Levinthal has no relevant financial interests with proprietary entity or entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.50 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.50 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 11/13/2012 | Last Modified On: 11/27/2013 | Expires: 11/27/2014



David J. Levinthal, MD, PhD

David J. Levinthal, MD, PhD Division of Gastroenterology, Hepatology & Nutrition
Office Address(es):
Digestive Disorders Center
200 Lothrop Street, 3rd Floor
Pittsburgh, PA 15213
Phone: (412) 647-8666
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