Sight Protection and Restoration: A Precision Medicine Approach to Retinal Degenerations

Dr. José-Alain Sahel discusses some of the advances and therapies for retinal degenerations.

Educational objectives:

Upon completion of this activity, participants should be able to:

• Recognize the patter and mechanisms of vision loss in retinitis pigmentosa
• Develop potential therapies for preventing vision loss
• Describe the translational pathway to clinical validation

Reading Resources:

1. Impact of Retinitis Pigmentosa on Quality of Life, Mental Health and Employment Among Young Adults. Chaumet-Riffaud AE, Chaumet-Riffaud P, Cariou A, Devisme C, Audo I, Sahel JA, Mohand-Said S. Am J Ophthalmol. 2017 Feb 22. pii: S0002-9394(17)30076-4. doi: 10.1016/j.ajo.2017.02.016. [Epub ahead of print] PMID: 28237413
2. Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss. Sabbah N, Sanda N, Authié CN, Mohand-Saïd S, Sahel JA, Habas C, Amedi A, Safran AB. Sci Rep. 2017 Feb 24;7:43223. doi: 10.1038/srep43223.
3. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Calippe B, Augustin S, Beguier F, Charles-Messance H, Poupel L, Conart JB, Hu SJ, Lavalette S, Fauvet A, Rayes J, Levy O, Raoul W, Fitting C, Denèfle T, Pickering MC, Harris C, Jorieux S, Sullivan PM, Sahel JA, Karoyan P, Sapieha P, Guillonneau X, Gautier EL, Sennlaub F. Immunity. 2017 Feb 21;46(2):261-272. doi: 10.1016/j.immuni.2017.01.006.

Disclosures:

Dr. Sahel has financial interests with the following any entity or entities producing health care goods or services as indicated below:

• Grant/ Research Support: LabEXLifesenses (ANR-10-LABX-65); ERC Synergy “Helmholtz” Banque Publique d'Investissement; Foundation fighting blindness
• Consultant: Pixium Vision; Genesight Biologics; Genesignal
• Stockholder: Pixium Vision; Genesight Biologics; Chronocom; chromolife

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 9/7/2017 | Last Modified On: 9/7/2017 | Expires: 9/7/2018