UPMC Physicians and Researchers Presented at American Association for the Study of Liver Diseases (AASLD) 2023 Meeting

The Liver Meeting 2023 was held in Boston from Nov. 10 to Nov. 14. Physicians and researchers from UPMC and the University of Pittsburgh shared their expertise in a range of liver conditions, including: 

Aaron W. Bell, PhD; Satdarshan (Paul) Monga, MD; Reben Raeman, MS, PhD

IFR2 Expression in B-Catenin-Mutated Hepatocellular Carcinomas Promotes Inflammation and Reduced Tumor Burden

Aaron W. Bell, PhD; Satdarshan (Paul) Monga, MD

Stellate Cell WNTS Regulate Endothelial Cell- Hepatocyte Zonation to Balance Hepatic Metabolism- Proliferation Homeostasis

Efficacy of RNAi-Mediated Beta-Catenin Inhibition in Multiple Immunocompetent Mouse Models of Hepatocellular Carcinoma

Loss of Glutamine Synthetase Exacerbates Myeloid Cell Induced Immunosuppression in B-Catenin-Mutated Hepatocellular Carcinomas

Aatur Singhi, MD, PhD; Satdarshan (Paul) Monga, MD

Beta-Catenin Influences B Cell Recruitment to the Tumor Microenvironment in Beta-Catenin-mutated Hepatocellular Carcinoma Contributing to Patient Survival

Aatur Singhi, MD, PhD; Satdarshan (Paul) Monga, MD; Reben Raeman, MS, PhD

Western Diet Dampens T Regulatory Cell Function to Fuel Hepatic Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease

Alan Noll, MD

#81 Psychological Distress Among Patients with Decompensated Cirrhosis and Their Family Caregivers

Quality of Life, Symptom Burden, Psychological Distress, and Prognostic Perceptions Among Patients with Decompensated Cirrhosis

Alan Noll, MD; Shari S. Rogal, MD, MPH

Cirrhosis Patient Perspectives on Palliative Care: A Survey Project

Amit D. Tevar, MD

#79 Development and Validation of an Algorithm for the Prediction of High-Risk Varices in Patients with Unresectable Hepatocellular Carcinoma (HCC)

Andrea F. DiMartini, MD

Experiences of Alcohol-related Liver Disease Liver Transplant Recipients with and without 6 Months of Pre-transplant Abstinence

Anwaar Saeed, MD

Sex-related difference in Efficacy and Safety of Immunotherapy in Hepatocellular Carcinoma: Systematic Review and Meta- Analysis of Landmark Phase III Trials and Validation in Routine Clinical Practice

Gavin E. Arteel, PhD

The Hepatic Proteome Changes in NASH – Susceptible C57BI6/J Mice Induced by an Obesogenic Diet

Gavin E. Arteel, PhD (Fei-Pi Lin, MD, Presenting)

#230 Rehabilitation in Liver Transplant Candidates Improves Fertility Metrics Leading to Improved Survival

Gavin E. Arteel, PhD; Juliane I Beier, PhD

The Environmental Toxicant Vinyl Chloride Dysregulates the Mitochondrial Response to Stress in Mice

Targeting Hepatic Calpain Activity Protects Against Experimental Nash Fibrosis in Mice

New Role of Calpain Activity in Experimental Alcohol-Related Liver Disease

Vinyl Chloride Potentiates Liver Injury Caused by Chronic Alcohol Consumption in Mice

James E. Squires, MD, MS

MTE #5 - Autoimmune Hepatitis: What to Do When Prednisone and Azathioprine Isn’t Enough: A-Link: #127 Utilizing a Learning Health Network Model for Improving Outcomes in Autoimmune Hepatitis

#121 Serum Bile Acids Are Associated with Native Liver Survival in Patients with Alagille Syndrome: Results from the Gala Study Group

Pediatric Liver Transplantation and The Role of Living Donation

#12 Surgical Biliary Diversion Is Associated with an Increased Risk of Liver Transplantation or Death in Alagille Syndrome

Kari Nejak-Bowen, MBA, PhD

The Editors' Cut: Basic and Translational Studies

Conditional Loss of B-Catenin Lowers Toxic Bile-Induced Hepatic Injury and Improves Cholestatic Outcome in Murine Model

The Role of Beta-Catenin in Regulating Autophagy During Porphyria

Naudia L. Jonassaint, MD

AASLD Postgraduate Course: Cirrhosis as a Multisystem Disorder

Innovations in Transplantation: Now and Beyond

Pamela M. Bloomer

Phase Angle Negatively Correlates with Liver Frailty Index and May Help Predict Likelihood of Discharge Home After Liver Transplant

Satdarshan (Paul) Monga, MD

Spatial Cellular Interactions and Functions in Liver Health and Disease

Met a Fibroblast Growth Factor 19 Co-Activation in Hepatocellular Carcinoma-Biological  Implications and Clinical Relevance

Dual Loss of B-and- Γ-Catenins from Cholangiocytes Leads to Acute Cholestasis and Mortality Due to Hepatobiliary Injury and Maladaptation as Revealed by Single-Nucleus RNA Sequencing

Shahid M. Malik, MD

Liver Specific Glomerular Filtration Rate Equations Provide Modest Improvement in 28-day Outcome Predication in Alcohol-associated Hepatitis

Shari S. Rogal, MD, MPH

Using Date-driven Strategies to Improve Transplant Access for Veterans with Cirrhosis

The Cascade of NAFLD Care in the VA: A Window of Opportunity

Alcohol Use Disorder Treatment During COVID-19 Among Veterans with Cirrhosis

Creation of a Population Health Disease Management Strategy for NAFLD in the Veterans Healthcare Administration

Stela Celaj, MD, PhD; Obaid Shakil Shaikh, MD

Acute Cellular Liver Rejection Following COVID-19 Infection