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Dr. Jankowitz provides an overview of breast cancer risk factors, as well as factors differentiating moderate and high-risk patients. She discusses methods of preventive therapy and the benefits and risks associated with such therapy.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Estimate risk of breast cancer associated with high-risk pathologies such as ADH, ALH, Borderline DCIS, and LCIS
  • Identify the amount of risk reduction conferred to high-risk patients with preventive therapy for breast cancer
  • Describe the benefit/risk ratio of preventive therapy and its duration in patients with an elevated risk of breast cancer

Reading Resources:

  1. JCO, (2007): 25(11); 1329-1333.
  2. Coopey SB, et al. SABCS, 2011: Abs S4-4
  3. Boyd, N. J Natl Cancer Inst 2011; 103:  704-5
  4. Domchek SM, et al. JAMA 2010;304: 967-75.
  5. Fisher, B. JNCI 1998. 90(18): 1371-1388.
  6. Vogel VG; et. al. JAMA. 2006;295: 2727-2741
  7. Vogel, VG. Cancer Prev Res 2010;3:696-706
  8. Cuzick, J. Cancer Res, 2009. 69(24 Supp): pAbstract 905.
  9. Iqbal, J. Cancer Treat Rev; 2011: July 18
  10. Freedman, AN.  J Clin Oncol 2011; 29:2327-2333.
  11. Goss, PE. N Engl J Med 364; 25: 2381-2391


Dr. Jankowitz has no relevant relationships with any entities producing healthcare goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 4/26/2012 | Last Modified On: 4/26/2012 | Expires: 4/25/2013

This course has been expired.