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Dr. McGuire provides an overview of screening methods for patients at high risk of developing breast cancer. She discusses surgical options, risks, and benefits for these high risk patients.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Compare the sensitivity and specificity of breast MRI to mammograpy in detecting cancer in a high risk population
  • Identify patients who are eligible for "high risk" screening with MRI
  • Discuss with patients with high familial risk their potential risk reduction with prophylactic mastectomy

Reading Resources:

  1. Brekelmans CT, Seynaeve C, Bartels CC, et al. Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk. J Clin Oncol. 2001 Feb 15;19(4):924-30.
  2. Kriege M, Brekelmans CT, Boetes C, Bet al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004 Jul 29,351(5):427-37.
  3. Hartmann LC, Schaid DJ, Woods JE, et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med. 1999 Jan 14,340(2):77-84.
  4. Rebbeck TR, Friebel T, Lynch HT, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2004 Mar 15;22(6):1055-62.
  5. Murthy V, Chamberlain RS. Defining a Place for Nipple Sparing Mastectomy in Modern Breast Care: An Evidence Based Review. Breast J. 2012 Jan 29. doi: 10.1111/j.1524-4741.2011.01220.x.


Dr. McGuire has no relevant relationships with any entities producing healthcare goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.25 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.025) continuing education units (CEU) which are equivalent to 0.25 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 5/1/2012 | Last Modified On: 5/1/2012 | Expires: 5/1/2013

This course has been expired.