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Dr. Kenneth E. Fasanella reviews recent studies in Gastroenterology regarding indications for use of proton pump inhibitors (PPI). Dr. Naudia Jonassaint presents the latest updates in Hepatology, specifically on portal hypertension, viral hepatitis B, and the reactivation of hepatitis cyst in patients.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Recognize the latest updates on indications for PPI use, including the AspECT trial data and the SUP-ICU trial data
  • Recall articles published in the past year dealing with PPI safety related to risk of dementia, bone fracture, and kidney disease in the context of previous published literature
  • Identify the risk of reactivation of Hepatitis C therapy during chemotherapy
  • Explain the relative risk associated with the long term use of the older formulation of Tenofovor Formulation (TDR) compared to the new formulation (TAF)
  • Recognize the proposed risk score for HE in Cirrhosis


Dr. Naudia Jonassaint has reported no relevant relationships with entities producing health care goods or services.

Dr. Kenneth E. Fasanella has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Consultant: Lygenesis, Inc. 

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded .1 continuing education units (CEU) which are equivalent to 1 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

ABIM MOC Part 2 Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

To receive your ABIM MOC Part 2 credit, you will need to complete the post-test with a pass rate of 100% and provide your date of birth and ABIM number, along with the other required fields.  This information will be shared with the American Board of Internal Medicine using the Accreditation Council for Continuing Medical Education Program and Activity Reporting System.

Release Date: 6/6/2019 | Last Modified On: 6/6/2019 | Expires: 6/8/2020

This course has been expired.