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Starting with patients who get better following the similar treatment regimens, Dr. Greg Siegle discusses what we can learn from successful targeted therapy and where neuroscience can help predict a response to treatment.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Clearly communicate with patients regarding brain mechanisms commonly associated with depression
  • Improve readiness to use of neuroscience in predicting response to treatment
  • Increase ability to target brain mechanisms of depression directly with novel interventions

Reading Resources:

  1. Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlates. Siegle GJ, Steinhauer SR, Friedman ES, Thompson WS, Thase ME. Biol Psychiatry. 2011 Apr 15;69(8):726-33.
  2. Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms. DeRubeis RJ, Siegle GJ, Hollon SD. Nat Rev Neurosci. 2008 Oct;9(10):788-96. Epub 2008 Sep 11. Review.
  3. Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: an fMRI investigation. Siegle GJ, Konecky RO, Thase ME, Carter CS. Ann N Y Acad Sci. 2003 Apr;985:481-4. No abstract available.


Dr. Siegle has non-financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Unpaid consultant: Trial IQ

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to 0.75 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 4/25/2012 | Last Modified On: 7/12/2013 | Expires: 7/12/2014

This course has been expired.