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After a general introduction of how we think about schizophrenia, Dr. Steinhauer discusses what psychologically oriented neurophysiology has brought to the understanding of the disease.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe how psychophysiological evaluation provides insights into underlying mechanisms that are related to expression of symptomatology and risk for schizophrenia
  • Determine the extent to which deviations in neurophysiological functioning may occur in both persons in schizophrenia and their relatives as indicators of underlying genetic factors
  • Evaluate the usage of neurocognitive assessment to predict and track improvement in cognition related to behavioral and pharmacological interventions

Reading Resources:

  1. Bonner-Jackson, A., Grossman, L.S., Harrow, M. & Rosen, C. (2010) Neurocognition in schizophrenia: A 20-year multi-follow-up of the course of processing speed and stored knowledge.  Comprehensive Psychiatry, vol. 51, 471-479.
  2. Condray, R., Steinhauer, S.R., van Kammen, D.P., and Kasparek, A. (2002). The language system in schizophrenia: Effects of capacity and linguistic structure. Schizophrenia Bulletin, 28: 475-490.
  3. Ford, J.M., & Mathalon, D.H. (2005). Corollary discharge dysfunction in schizophrenia:  Can it explain auditory hallucinations?  International Journal of Psychophysiology, vol. 58, 179-189.
  4. Gershon, E.S., Alliey-Rodriguez, N., & Liu, C.  (2011). After GWAS: Searching for genetic risk for schizophrenia and bipolar disorder.  American Journal of Psychiatry, vol. 168, 253-256.
  5. Gottesman, I.I.;, & Gould, T.D., (2003).  The endophenotype concept in psychiatry: Etymology and strategic intentions.  American Journal of Psychiatry, vol. 160, 636-645
  6. Granholm, E., &Steinhauer, S.R. (Editors). (2004).  Pupillary function, cognition, and emotional processing. .  International Journal of Psychophysiology , vol. 52, p. 1-112. 
  7. Neuchterlein, K.H., Green, M.F., Kern, R.S., et al. (2008).  The MATRICS Consensus Battery, Part 1:  Test selection, reliability, and validity. American Journal of Psychiatry, vol., 165, 202-213.
  8. Olincy, A., Braff,, D.L., Adler, L.E. et al. (2010). Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: Results from the Consortium on Genetics of Schizophrenia.  Schizophrenia Research, vol. 119, 175-182.
  9. Steinhauer, S.R., & Condray R. (Editors). (2010).  Psychophysiology of Language Processes in Psychopathology.  International Journal of Psychophysiology, vol. 75, p. 83-216. 
  10. Steinhauer, S.R., and Friedman, D. (1995). Cognitive psychophysiological indicators of vulnerability in relatives of schizophrenics. In: Miller, G.A. (Ed.), The behavioral high-risk strategy in psychopathology. New York: Springer-Verlag, pp. 158-180.
  11. Steinhauer, S.R., and Hakerem, G. (1992).  The pupillary response in cognitive psychophysiology and schizophrenia. In: Friedman, D., and Bruder, G. (Eds.), Psychophysiology and experimental psychopathology. Annals of the New York Academy of Sciences, 658: 182-204.
  12. Zubin, J., and Steinhauer, S.R. (1981). How to break the logjam in schizophrenia: A look beyond genetics. The Journal of Nervous and Mental Disease, 169: 477-492.


Dr. Steinhauer has no relevant relationships with any entities producing healthcare goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 10/11/2012 | Last Modified On: 6/29/2014 | Expires: 6/29/2015

This course has been expired.