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Dr. Jeffrey K. Yao provides an overview for membrane pathology in schizophrenia as a function for oxidative stress and essential fatty acids.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Describe essential polyunsaturated fatty acids (PUFAs) and the pivotal role in membrane pathology in schizophrenia
  • Describe oxidative stress and membrane dysfunction as part of schizophrenia pathology
  • Discuss how essential PUFAs relate to the oxidative stress or the free radical process

Reading Resources:

  1. Yao, J. K., Reddy, R. D., Condray, R., Long, T. and Haas, G. (2012) Pathological and therapeutic implications of omega-3 fatty acids in schizophrenia. In: The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention. McNamara, R.K. (ed.), Nova Science Publishers, Inc., Hauppauge, NY.
  2. Yao, J.K., and Keshavan, M.S. (2011) Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View. Antioxidants & Redox Signaling 15: 2011-2035.
  3. Condray, R., and Yao, J.K. (2011) Cognition, dopamine and bioactive lipids in schizophrenia. Frontiers in Bioscience S3: 298-330.
  4. Conklin, S.M., Muldoon, M.F., Reddy, R.D. and Yao, J.K. (2008) Fatty acids and psychiatric disorders.  In: Fatty Acids in Foods and Their Health Implications (3rd edition), Chow, C.K. (ed.), Marcel Dekker, Inc., New York, pp. 1229-1256.


Dr. Yao has no relevant relationships with any entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to 0.75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/25/2013 | Last Modified On: 3/25/2013 | Expires: 3/25/2014

This course has been expired.