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Pulmonologist, Dr. Sally E. Wenzel discusses phenotyping of difficult to treat asthma patients and its implications for treatment in this UPMC CME presentation.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Evaluate the concept that asthma is not a single disease.
  • Identify asthma phenotypes.
  • Begin to identify treatment approaches based on phenotype.

Reading Resources:

  1. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95. Epub 2009 May 29. Erratum in: Am J Respir Crit Care Med. 2009 Oct 15;180(8):796. PubMed PMID: 19483109; PubMed Central PMCID: PMC2742757.
  2. Wenzel SE. Asthma: Defining of the Persistent Adult Phenotypes.  Lancet; 368: 804-13, 2006. 
  3. Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, Gaston BM, Bleecker ER, Moore WC; for the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2010 Dec 30. [Epub ahead of print] PMID: 21195471.

Disclosures:

Dr. Wenzel has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support:GSK, AstrZeneca, sanofi Aventis
  • Consultant: GSK, AztraZeneca

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to 0.75 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 9/29/2011 | Last Modified On: 7/14/2014 | Expires: 7/14/2015

This course has been expired.