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This course will discuss statin-induced myopathic events, including prevalence, predictors, and case study examples.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Identify common features of statin induced musculoskeletal complaints.
  • Recognize an autoimmune form of necrotizing myopathy induced by statins.
  • Review prevalence and predictors of myopathic events.

Reading Resources:

  1. Nichols GA, Koro CE. Does Statin Therapy Initiation Increase the Risk for Nyopathy? An Observational Study of 32,225 Diabetic and Nondiabetic Patients. Clin Ther. 2007 Aug;29(8):1761-70.
  2. MRC/BHF Heart Protection Study Collaborative Group, Armitage J, Bowman L, Collins R, Parish S, Tobert J. Effects of Simvastatin 40 mg Daily on Muscle and Liver Adverse Effects in a 5-Year Randomized Placebo-Controlled Trial in 20,536 High-Risk People. BMC Clin Pharmacol. 2009 Mar 31;9:6.
  3. Backes JM, Venero CV, Gibson CA, Ruisinger JF, Howard PA, Thompson PD, Moriarty PM. Effectiveness and Tolerability of Every-Other-Day Rosuvastatin Dosing in Patients With Prior Statin Intolerance. Ann Pharmacother. 2008 Mar;42(3):341-6.


Dr. Oddis has reported no relevant relationships with any entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 5/18/2015 | Last Modified On: 5/18/2015 | Expires: 5/18/2016

This course has been expired.