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Dr. Craig Byersdorfer provides an overview of allogeneic stem cell transplantation, recent updates to the classical model of hematopoiesis, native versus post-transplant hematopoiesis, de-differentiation of committed effector cells, and separation of pathologic versus physiologic immune responses based on metabolic changes.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Integrate the specialized roles of stem versus immune cells into better post-transplant care
  • Incorporate scientific updates into an improved model of hematopoiesis
  • Define ways to separate physiologic from pathologic immune responses post-transplant, including in the use of energy substrates 

Reading Resources:

  2. Kawamoto and Katsura, Trends Immunol. (2009) 30:193
  3. Rich A.R. Arch. Path. (1936) 22:228
  4. Wu et al. Cell Stem Cell (2014) 14:486
  5. Kim et al. Cell Stem Cell (2014) 14:473
  6. Biasco, …Naldini, and Aiuti et al. ASH 2014 Plenary session
  7. Sun et al. Nature (2014) 514:322
  8. Riddell et al. Cell (2014) 157:549
  9. Ferrara et al. Lancet (2009) 373:1550
  10. Davies et al. Biol Blood Marrow Transplant (2009) 15:360
  11. Leather and Wingard. Infect Dis Clin North Am (2001) 15:483
  12. Fox, Hammerman and Thompson. Nat Rev Immunol (2005) 5:844
  13. Gatza and Wahl et al. Science Trans Med (2011) 3:1
  14. Byersdorfer et al. Blood (2013) 122:3230


Dr. Byersdorfer has reported no relevant relationships with any entities producing health care goods or services.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1 contact hour. 

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 6/17/2015 | Last Modified On: 10/19/2016 | Expires: 10/19/2017

This course has been expired.