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Diwakar Davar, MD, discusses the intestinal microbiome.

Educational Objectives 

Upon completion of this activity, participants should be able to: 

  • Explain that the intestinal microbiome is implicated in the development of response to anti-PD-1 immunotherapy
  • Explain that the intestinal microbiome is implicated in the development of immune-related adverse events (irAEs) to anti-PD-1 immunotherapy
  • Describe that the use of antibiotics and proton pump inhibitors adversely affect responses to anti-PD-1 immunotherapy by impacting the microbiome


Dr. Davar has financial interests with the following entity or entities producing health care goods or services as indicated below:

Grant/Research Support: Arcus, Merck, Bristol-Myers Squibb, Checkmate Pharmaceuticals, CellSight Technologies, Tesaro, and GlaxoSmithKline
Consultant: Incyte,Merck, Immunocore, Array-Biopharma
Other: US Patent/63/124,231 "Compositions and Methods for Treating Cancer"  December 11, 2020

All presenters' disclosures of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services used on or consumed by patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers, and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of .75 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website four weeks postcompletion at and follow the link to the Credit Transcript page.

Release Date: 6/15/2021 | Last Modified On: 6/15/2021 | Expires: 6/15/2022

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