The International Society for Heart and Lung Transplantation (ISHLT) 37th Annual Meeting and Scientific Sessions — April 4-8, San Diego
March 24, 2017
The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department will be well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 37th Annual Meeting and Scientific Sessions in San Diego, Ca. Faculty research will be featured in both oral and poster presentations throughout the conference, including:
Tuesday, April 4
ACAD Core ID – ISHLT Academy: Core Competency Course in Infectious Diseases in Thoracic Transplantation and Mechanical Circulatory Support
SESSION 2: This Could Happen to You…Drug Interactions and Toxicity Errors to Avoid with Anti-infectives and Immunosuppression and Cracking the Therapeutic Drug Monitoring Code
Presented by: Christopher R. Ensor
Wednesday, April 5
Opening Plenary Session
Co-Chair: Jeffrey J. Teuteberg
Symposium: When Should We Call It Quits? The Efficacy of Interventions to Ameliorate Psychosocial Risk Factors
When Do We Call It Quits: Intervention Strategies and Outcomes for Medical Non-Adherence
Presented by: Mary Amanda Dew
Are All Substances Made Equal?
Presented by: Andrea DiMartini
Oral Session: Cutting Edge Updates in Infectious Diseases
0039 – Clinical Risk Factors for Invasive Aspergillosis in Lung Transplant Recipients: Results of an International Cohort Study
Presented by: C. Aguilar, B. Hamandi, C. Fegbeutel, F. P. Silveira, E. A. Verschuuren, P. Ussetti, P. V. Chin-Hong, A. Sole, C. Holmes-Liew, E. M. Billaud, P. A. Grossi, O. Manuel, D. J. Levine, R. G. Barbers, D. Hadjiliadis, L. Singer, S. Husain
Oral Session: Bugs and Devices: A Bad Combination
0047 – Epidemiology of Fungal Infections (FI) in Mechanical Circulatory Support Device (MCSD) Recipients: Analysis of IMACS Registry 2013-2015
Presented by: O. Morrissey, R. Xie, J. Schaenman, S. Husain, M. Mooney, T. Nakatani, R. Kormos, M. Gómez-Bueno, S. Aslam, Y. Pya, M. Hannan
Symposium: Thinking Outside the Box: Extra-Pulmonary Management in Lung Transplantation
New Lungs – Old Sinuses: Friends or Foes?
Presented by: Joseph M. Pilewski
Mini Oral Session: Allocation, Bridging and Lung Allograft Assessment Strategies
0116 – Mechanical Ventilation and Extracorporeal Membrane Oxygenation (ECMO) as a Combined Bridging Strategy to Lung Transplantation: Significant Gains in Survival
Presented by: A. L. Du, J. Hayanga, J. D’Cunha, M. Tuft, M. Morrell, N. Shigemura
Mini Oral Session: The Hardware of MCS
0131 – Association Between the Use of Invasive Hemodynamic Monitoring and Outcomes with Percutaneous Left Ventricular Support: A Call for Standardization?
Presented by: J. J. Teuteberg, W. O’Neill
0132 – Analysis of Right Ventricular (RV) Regional and Global Systolic Function by Gated Blood Pool SPECT (GBPS) in Patients Undergoing Left Ventricular Assist Device (LVAD) Implantation
Presented by: C. B. Link, A. Nayak, P. Soman, M. A. Simon, J. J. Teuteberg, L. Lagazzi, A. Althouse, R. Kormos.
Poster Session 1: Heart Failure
0563 – Does Heart Failure with a Lower Ejection Fraction Mean Higher Costs? Insights from Data Analytics Across a Large Health Care System
Presented by: C. B. Link, S. Koscumb, P. Lynch, R. Ramani, M. Shullo, O. Marroquin, J. J. Teuteberg
0570 – Utilizing Data Analytics to Identify Patients at Highest Risk of Heart Failure Readmission
Presented by: C. B. Link, S. Koscumb, P. Lynch, R. Ramani, M. A. Shullo, O. Marroquin, J. J. Teuteberg
Poster Session 1: Junior Faculty Clinical Case Reports
0832 – Complications Following Lung Transplantation in a Patient with Short Telomere Syndrome
Presented by: C. Naik, M. Morrell
0847 – Successful Resolution of Refractory Rejection with Cyclophosphamide in a Lung Transplant Recipient Intolerant to Cell Cycle and Proliferation Signal Inhibitors
Presented by: C. A. Moore, M. R. Pipeling, C. R. Ensor
0865 – Pay Me Now or Pay Me Later: A Tale of Two Sensitized Pediatric Heart Transplant Candidates
Presented by: M. Mangiola, B. Feingold, D. Magnetta, S. West, S. Miller, M. Zinn, M. Marrari, A. Zeevi
Thursday, April 6
Sunrise Symposium: “Those Darn CARVs”: Community Acquired Respiratory Viruses in Lung Transplant
In the Pipeline: Novel Therapeutics
Presented by: Christopher Ensor
Symposium: Antibodies in Mechanical Circulatory Support: The Phantom Menace
Epidemiology and Risk of the Sensitized MCS Patient
Presented by: Michael Shullo
Symposium: Taming of the Shrew: Mycobacterium Abscessus in Lung Transplantation
Management of M. Abscessus in the Lung Transplant Candidate: Preparation for Transplantation
Presented by: Fernanda Silveira
Symposium: HLA, AMR and DSA – Approaching Antibodies in Kids
Before Transplant: Why the PRA Doesn’t Matter Anymore
Presented by: Brian Feingold
0225 – Neopterin Elevation and Survival Following Left Ventricular Assist Device Implantation
Presented by: M. M. Lander, M. Mercurio, K. Hanley-Yanez, M. S. Sharbaugh, A. D. Althouse, M. A. Simon, J. J. Teuteberg, L. Lagazzi, C. M. Sciortino, C. McTiernan, R. Kormos, D. M. McNamara
Oral Session: Contemporary LVAD Trials – Same Old Song or New Tune?
0150 – ENDURANCE Destination Therapy Trial Outcomes as Stratified by Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Classification
Presented by: S. V. Pamboukian, F. D. Pagani, J. J. Teuteberg, R. L. Kormos, C. C. Caldeira, C. H. Selzmann, J. K. Kirklin, B. B. Reid, E. C. McGee, C. A. Milano, J. G. Rogers
Oral Session: Contemporary Challenges in Pediatric Heart Transplant
0182 – Impact of Newly Detected Donor Specific Anti-HLA Antibody in the First Year After Pediatric Heart Transplantation
Presented by: A. I. Dipchand, S. Webber, K. Much, B. Feingold, C. Bentlejewski, E. D. Blume, R. Shaddy, C. Canter, J. Lamour, W. Mahle, W. Zuckerman, H. Diop, Y. Morrison, B. Armstrong, D. Ikle, J. Odim, A. Zeevi
Mini Oral Session: Novel Strategies and Mechanisms in Lung Preservation, Heart Failure and Assist Devices
0215 – Microvasculature Analysis Using Micro CTA Techniques for Lungs After Different Preservation Process
Presented by: S. Tane, K. Noda, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura
Poster Session 2: Lung Transplantation
Poster Discussant: Christopher R. Ensor
0988 – A Prophylaxis-Free, Pre-Emptive Approach to the Management of CMV After Lung Transplantation: Single Center Results
Presented by: A. Bertani, P. Vitulo, A. Mularoni, P. Grossi, L. De Monte, E. Russo, M. Beretta, L. Martino, A. Callari
Poster Session 2: Nursing, Health Sciences, Allied Health
Poster Discussant: Annette J. Devito Dabbs
Friday, April 7
Sunrise Symposium: Contrasts and Similarities in Children and Adults: IPAH, Portopulmonary Hypertension, and Perioperative Management
Co-Chair: Brian Feingold
Symposium: Dealing with Antibodies Before and After Heart Transplant
Co-chair: Michael Shullo
Symposium: E-Health, Wearables, Social Media and Big Data in Transplantation: Fancy Toys or True Care Innovations?
The Importance of Involving End-Users When Designing Interactive Health Technology Applications for Self-Management Support
Presented by: Annette Devito Dabbs
New Ethical and Legal Challenges Surrounding E-health in Transplantation
Presented by: JiYeon Choi, PhD, RN
Oral Session: New and Improving? Evolving Outcomes with MCS
0266 – Which INTERMACS 4-7 Patients Are at Low Risk for Mortality at One Year? Insights from the INTERMACS Database
Presented by: J. J. Teuteberg, A. D. Althouse, M. Shullo, N. Kunz, K. Lockard, E. Dunn, L. Lagazzi, C. Sciortino, J. Cowger, S. Joseph, R. L. Kormos
Oral Session: Saved by the Bell: Overcoming Adherence and Frailty
0331 – A Trajectory Analysis of Adherence to Recommended Exercise Following Lung Transplantation
Presented by: M. Alrawashdeh, J. Choi, A. DeVito Dabbs
Oral Session: PATH to Better Outcomes: Diagnostics in Heart and Lung Transplantation
0346 – Late Graft Dysfunction After Pediatric Heart Transplantation Is Associated with Fibrosis and Decreased Capillary Density by Automated, Whole-Slide Imaging
Presented by: B. Feingold, J. Picarsic, A. Lesniak, M. Wood-Trageser, B. Popp, A. J. Demetris
Oral Session: Heart Failure in MCS
0355 – The Duration of Inotropic Support and Survival After Left Ventricular Assist Device
Presented by: E. Grandin, D. Mooney, K. Kennedy, M. S. Kiernan, R. D. Kociol, J. J. Teuteberg, F. D. Pagani, A. C. Gaffey, P. Atluri, E. Y. Birati, S. Myers, D. Naftel, G. Oliveira, K. E. Simpson, R. W. Yeh, J. K. Kirklin, R. L. Kormos, J. Rame
0356 – The Incidence of Early and Late Clinical Right Heart Failure and the Impact on Survival After Continuous Flow Mechanical Support: Insights from the New INTERMACS Definition of Right Heart Failure
Presented by: J. J. Teuteberg, G. Studdard, F. Pagani, M. Kiernan, G. Oliveria, E. Rame, P. Alturi, A. Gaffey, E. W. Grandin, J. Kirlin, S. Myers, C. Collum, R. L. Kormos
Mini Oral Session: Pediatric Heart Failure, MCS, and Peri-Transplant Issues
0416 – Post-Transplant Outcomes of Patients Supported with the Berlin Heart EXCOR as a Bridge to Transplantation: A Multi-Institutional Study
Presented by: A. Jeewa, M. Imamura, C. Canter, R. Niebler, C. VanderPluym, D. Rosenthal, J. K. Kirklin, M. Tresler, M. McMullan, V. Morell, M. Turrentine, R. Amedur1, K. Nguyen, K. Kanter, J. Conway, R. Gajarski, C. D. Fraser Jr
Mini Oral Session: Assessing and Managing the Failing Right Ventricle
0434 – Painting Profiles of Ambulatory Advanced Heart Failure: A Report from the REVIVAL Registry
Presented by: M. M. Kittleson, P. Shah, A. Lala, R. McLean, S. Pamboukian, D. Horstmanshof, J. Thibodeau, K. Shah, D. Lanfear, J. Teuteberg, W. Taddei-Peters, S. Khalatbari, L. Stevenson, D. Mann, K. Aaronson, G. Stewart
Mini Oral Session: Patient Centered Outcomes in Advanced Heart and Lung Disease
0456 – Most Survivors Are Glad to Have a VAD
Presented by: L. W. Stevenson, J. Lindenfeld, K. Grady, J. Vader, M. Givertz, D. Naftel, T. Baldwin, S. Myers, R. Kormos, J. K. Kirklin
0457 – Slower Gait Speed as a Measure of Frailty Tracks with INTERMACS Profiles, Quality of Life and Predicted Mortality in Ambulatory Patients with Advanced Heart Failure: A Report from the REVIVAL Registry
Presented by: A. Lala, A. Ambardekar, J. Estep, J. Stehlik, M. Mountis, D. Haas, D. Horstmanshof, J. Thibodeau, K. Shah, D. Lanfear, J. Teuteberg, W. Taddei-Peters, S. Khalatbari, L. Stevenson, D. Mann, K. Aaronson, G. Stewart
Poster Session 3: Basic Science & Translational Research
1147 – Pyroptosis of Passenger Leukocytes Negatively Impacts the Quality of Lung Grafts During Ex Vivo Lung Perfusion
Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura
1151 – Optimal Perfusate Oxygenation During Ex Vivo Lung Perfusion Can Promote Alveolar Proliferation in Lung Grafts
Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura
1154 – DUAL Ex Vivo Lung Perfusion Techniques Can Contribute to Better Posttransplant Outcomes Through Reconditioning Hypoxic Cells in Lung Grafts
Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura
1155 – ST266 Improves Oxygenation and Reduces Tissue Injury in an In-Situ Rat Left Lung Ischemia-Reperfusion Model
Presented by: C. F. Evans, X. Wang, X. Liu, R. Mishra, V. Mishra, S. Rahimpour, A. Zeevi, R. Banas, S. M. Pham
1160 – Bronchial Artery Sparing Lung Preservation: Is It Feasible?
Presented by: S. Tane, K. Noda, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura
1161 – Nitrite Improves Mitochondrial Dysfunction Induced by Hypoxia/Reoxygenation in Lung Epithelial Cells: Implications for Ischemia-Reperfusion (I/R) Injury in Lung Transplantation
Presented by: A. Kumar, C. Corey, S. Shiva, M. T. Gladwin, J. D’Cunha
Poster Session 3: Heart Transplantation
1192 – Informative and Uninformative Variables in the Scientific Registry of Transplant Recipients
Presented by: E. M. Hsich, L. Thuita, D. McNamara, J. G. Rogers, J. Schold, E. H. Blackstone, H. Ishwaran
Poster Session 3: Lung Transplantation
1244 – Systematic Review and Meta-Analysis of Death After Posttransplant Lymphoproliferative Disease in Lung Transplantation
Presented by: C. A. Moore, J. Cheng, C. J. Iasella, A. R. Glanville, M. R. Morrell, R. B. Smith, J. Hayanga, J. F. McDyer, C. R. Ensor
1255 – Successful Maintenance Belatacept-Based Immunosuppression in Lung Transplantation Recipients Who Failed Calcineurin Inhibitors
Presented by: C. J. Iasella, R. J. Winstead, C. A. Moore, B. A. Johnson, M. R. Morrell, J. Hayanga, A. Zeevi, E. A. Lendermon, J. F. McDyer, C. R. Ensor
1263 – Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Reduced Chronic Lung Allograft Dysfunction
Presented by: C. A. Moore, K. M. Harrigan, C. J. Iasella, R. Venkataramanan, M. R. Morrell, J. Hayanga, J. D’Cunha, A. Zeevi, J. McDyer, C. R. Ensor
Poster Session 3: Mechanical Circulatory Support
1303 – Pre-Implant Under-Expression of CCR3 and Its Ligands Predicts One-Year Mortality in Left Ventricular Assist Device Patients
Presented by: A. Nayak, C. Neill, R. L. Kormos, L. Lagazzi, I. Halder, C. McTiernan, J. Larsen, A. Inashvili, J. Teuteberg, T. N. Bachman, K. Hanley-Yanez, D. M. McNamara, M. A. Simon
Saturday, April 8
Sunrise Symposium: Mechanical Circulatory Support – The Interface of Design and Outcome
Co-chair: R. Kormos
Sunrise Symposium: Extracorporeal Photopheresis: Shedding Light on Rejection?
Co-Chair: Matthew R. Morrell
Plenary Session 3
0496 – Advanced Therapy Utilization and Survival in Ambulatory Patients with Advanced Heart Failure: Results from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry
Presented by: A. V. Ambardekar, M. Kittleson, M. Palardy, M. Mountis, R. Forde-McLean, A. DeVore, S. Pamboukian, J. Thibodeau, J. Teuteberg, L. Cadaret, R. Xie, L. Stevenson, G. Stewart
Oral Session: Not the Usual Suspects: Driving Outcomes in MCS
0500 – Temporal Patterns of Adverse Events (AE) Occurring within 60 Days of LVAD Implantation: The Concept of the AE Cascade
Presented by: J. O. Larsen, A. D. Althouse, J. J. Teuteberg, C. M. Sciortino, C. V. Nikas, L. F. Lagazzi, M. S. Sharbaugh, S. U. Iturra, N. M. Kunz, E. M. Dunn, K. L. Lockard, R. L. Kormos
Oral Session: Seeing the Patient Beyond the Device
0504 – Glad to Have a VAD Across Intermacs Profiles
Presented by: F. Pagani, M. Kittleson, G. Stewart, A. DeVore, M. Brinkley, S. Myers, M. Miller, D. Naftel, J. J. Teuteberg, L. W. Stevenson
Oral Session: Getting to the Heart of the Matter: Psychosocial Predict Outcomes in Transplant and MCS
0243 – Social and Clinical Characteristics Associated with Increased Short Term Mortality in Non-Inotrope Dependent Patients Undergoing Left Ventricular Assist Device Therapy: Results from InterMACS
S. M. Joseph, R. L. Kormos, J. Teuteberg, A. Althouse, J. Cowger.
Oral Session: The Weighting Game: Impact of Obesity, Age, and Other Comorbidities in MCS
0471 – Adverse Events After Device Implantation Are More Common in Obese Patients: An IMACS Registry Analysis
Presented by: S. J. Forest, R. Xie, J. K. Kirklin, J. A. Cowger, Y. Xia, A. I. Dipchand, C. Sivathasan, C. Merry, L. H. Lund, R. Kormos, T. Nakatani, U. Jorde, D. J. Goldstein
Oral Session: Optimizing Early Outcomes after Lung Transplantation
0482 – Treatment of Antibody Mediated Rejection of the Lung Allograft with Carfilzomib-Based Therapy
Presented by: C. R. Ensor, A. Zeevi, S. A. Yousem, M. Mangiola, M. Marrari, M. R. Morrell, J. M. Pilewski, J. D’Cunha, J. F. McDyer
Oral Session: Influencing Long-term Outcomes in Lung Transplantation
0516 – Regulation of KLRG1 Gene Expression by T-bet Correlates with Human Cytomegalovirus-Specific CD8+ T Cells Effector Function
Presented by: A. Hoji, I. Popescu, M. Pipeling, H. Mannem, J. McDyer
