International Society for Heart and Lung Transplantation (ISHLT) 36th Annual Scientific Sessions
April 18, 2016
The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department will be well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 36th Annual Meeting and Scientific Sessions in Washington, DC. Faculty research will be featured in both oral and poster presentations throughout the conference, including:
Wednesday, April 27
Pre-Meeting Symposium 01: Anticoagulation and MCS: Can We Do Better?
Co-Chair: Michael A. Shullo
Pre-Meeting Symposium 06: Back to the Future: Cell Therapy for Thoracic Organ Failure and Transplant?
Myeloid Cells to Induce Transplant Tolerance
Presented by: Angus Thomson
Pre-Meeting Symposium 07: The Future is Here: Emerging Issues in Infectious Disease
Mycobacterium Abscessus and Friends
Presented by: Fernanda Silveira
Pre-Meeting Symposium 13: Child’s Play: Infectious Risk After Transplant During Everyday Life
Outbreak – Measles, Varicella and Mumps
Presented by: Marian G. Michaels
Pre-Meeting Symposium 16: When Right is Wrong! Management of the Dying Right Ventricle
Peering Through the Looking Glass: Imaging the Right Ventricle
Presented by: Marc A. Simon
Pre-Meeting Symposium 19: Between a Rock and a Hard Place: Debating Treatment Decisions for Marginal Psychosocial Candidates
DEBATE 3: Substance Use: It’s OK To Dabble (PRO)
Presented by: Mary Amanda Dew
Pre-Meeting Symposium 22: Great Debates in MCS
DEBATE 2: INTERMACS 4-7: The Time is Now (PRO)
Presented by: Jeffrey J. Teuteberg
Pre-Meeting Symposium 28: Lifecycle Journey of Hepatitis C Heart Failure Patient in 2016
Immunosuppression— A Tricky Balance?
Presented by: Michael Shullo
Poster Session 1: Basic Science
0474 – Refinement of Ex Vivo Lung Perfusion Techniques for Better Microvasculature Maintenance in Lung Grafts
Presented by: K. Noda, S. Haam, Y. Wu, J. D’Cunha, J. D. Luketich, N. Shigemura
0490 – Identification of Hypoxic Cells in Lung Grafts for Future Cell Targeted Therapy for Obliterans Bronchiolitis
Presented by: K. Noda, H. Hara, S. Haam, J. D’Cunha, J. D. Luketich, N. Shigemura
0500 – CD8+ IL-17 Responses and Obliterative Airway Disease Persist in T-bet-/- Mouse Recipients of Lung Transplant Treated with Low Dose Azithromycin Therapy
E. A. Lendermon, J. M. Dodd-o, L. Guo, T. A. Coon, C. R. Ensor, C. P. O’Donnell, J. F. McDyer
0505 – Relationship between Grafts’ Quality, Glucose Consumption and IL-6 Production during Ex Vivo Lung Perfusion
Presented by: K. Noda, S. Haam, J. D’Cunha, J. D. Luketich, N. Shigemura
0551 – Poor Blood Pressure Control Is Independently Associated with Renal Dysfunction After Heart Transplant
Presented by: M. Osnard, A. D. Althouse, L. Krall, C. Newman, C. Grabowski, F. Speicher, R. Zomak, L. Lagazzi, R. L. Kormos, M. Shullo, J. J. Teuteberg
Poster Session 1: Lung Transplantation
0646 – Pre-Treatment High Titer DSA Is Associated with Non-Responsiveness to Carfilzomib-Based AMR Therapy in Lung Transplant Recipients
Presented by: A. Zeevi, M. Marrari, M. R. Morrell, S. A. Yousem, J. M. Pilewski, J. D’Cunha, J. F. McDyer, C. R. Ensor.
Poster Session 1: Mechanical Circulatory Support
0706 – Right Ventricular Failure in Patients with Left Ventricular Assist Devices Is Associated with Downregulated Chemokine Receptors and Altered Right Ventricular Pressure Waveforms
Presented by: T. N. Bachman, R. Vanderpool, M. Jacus, A. Nayak, O. Hunter, A. Inashvili, L. Lagazzi, J. J. Teuteberg, C. McTiernan, K. Hanley-Yanez, D. McNamara, R. L. Kormos, M. Simon
0717 – Worsening Renal Function after Ventricular Assist Device Placement Is Associated with Twice the Risk of Death over 3 Years
Presented by: J. E. Holtz, A. N. Potter, N. C. Macpherson, D. Nguyen, R. L. Kormos, J. J. Teuteberg, J. A. Kellum
Thursday, April 28
Concurrent Session 07: It’s Tough to Make Predictions, Especially about the Future: Outcomes in MCS
Abstract Session Chair: Jeffrey J. Teuteberg
0039 – Insights from INTERMACS into Patient Characteristics Leading to Futility in LVAD Therapy
Presented by: R. L. Kormos, F. D. Pagani, A. D. Althouse, L. Warner Stevenson, J. J. Teuteberg, J. B. Young, J. K. Kirklin
Concurrent Session 08: Quality Over Quantity? Quality of Life in MCS
Abstract Session Chair: Mary Amanda Dew
Concurrent Session 11: The Heartbreak of Rejection: All Against the Graft
0066 – Initial Analysis of the Donor-Derived Cell-Free DNA – Outcomes AlloMap Registry (D-OAR) Study in Heart Transplant Recipients Undergoing Surveillance for Rejection
Presented by: J. A. Kobashigawa, K. Khush, J. J. Teuteberg, M. Song, M. Grskovic, D. Hiller, R. Woodward, E. Deljkich, J. Yee, F. Latif, N. Sulemanjee, S. Murali
Concurrent Session 15: Let’s Be Specific: Donor Specific Antibodies – Challenges Ahead
The Timeline of DSA after Cardiac Transplantation
Presented by: A Vu, J. J. Teuteberg, A. Zeevi, M. A. Shullo
Mini Oral 04: Donor and Recipient Management in Lung Transplantation
0165 – On-Demand Immunoglobulin-G Replacement Is Not Associated with Benefits in Lung Transplant Recipients with Hypogammaglobulinemia
Presented by: A. B. Lichvar, C. R. Ensor, M. R. Morrell, J. M. Pilewski, J. Hayanga, J. D’Cunha, A. Zeevi, J. F. McDyer, A. A. Petrov
0166 – Carfilzomib-Based Therapy Produces Favorable Outcomes for Antibody Mediated Rejection of the Lung Allograft
Presented by: C. R. Ensor, A. Zeevi, M. Marrari, M. R. Morrell, S. A. Yousem, J. M. Pilewski, J. D’Cunha, J. F. McDyer
0168 – Extracorporeal Membrane Oxygenation (ECMO) as a Bridge to Lung Transplantation: Identifying Predictors of Mortality
Presented by: J. A. Hayanga, N. Shigemura, E. Chan, T. Richards, M. Morrell, J. D. Luketich, J. D’Cunha
Mini Oral 06: Pharmacy & Pharmacology and Mechanical Circulatory Support
0184 – CYP3A5 Pharmacogenetic Testing Predicts High Tacrolimus Dose Requirements Early after Cardiac Transplantation
Presented by: K. M. Deininger, A. Vu, R. L. Page II, A. V. Ambardekar, J. Lindenfeld, C. L. Aquilante
Poster Session 2: Heart Transplantation
0783 – Simple Technique for Open Sternal Wound Closure after Cardiac Transplant or LVAD
Presented by: U. Bansal, A. Bansal, J. K. Bhama
Poster Session 2: Lung Transplantation
0846 – Donor Derived Disease Transmission Events in Thoracic Organ Transplantation: Data Reviewed by the OPTN Ad Hoc Disease Transmission Advisory Committee
Presented by: J. M. Schaenman, A. Wilk, S. Tlusty, M. A. Nalesnik, M. G. Michaels, C. Wolfe, D. Kaul
0866 – Soluble CD14 and LBP as Markers for Primary Graft Dysfunction
Presented by: K. Ramphal, E. Cantu, M. Porteous, M. Oyster, S. Kawut, D. J. Lederer, R. Shah, S. Arcasoy, L. Snyder, M. Hartwig, S. Palmer, K. M. Wille, L. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, J. D. Christie, J. Diamond
Poster Session 2: Nursing, Health Sciences, Allied Health
0960 – Tales of Roller Coaster Rides and Resilience: Lung Transplant Caregivers in Their Own Words
Presented by: A.J. Haines
Poster Session 2: Pediatrics
0982 – Cost Effectiveness of Ventricular Assist Device Destination Therapy for Advanced Heart Failure in Duchenne Muscular Dystrophy
Presented by: D. A. Magnetta, J. Kang, P. D. Wearden, K. J. Smith, B. Feingold
Poster Session 2: Pulmonary Hypertension
1004 – PVR Predicts Cardiac Hospitalizations in Pulmonary Hypertension Associated with HFpEF and HFrEF
Presented by: R. R. Vanderpool, M. Saul, S. Nouraie, M. T. Gladwin, M. A. Simon
Friday, April 29
Sunrise Symposium 03: Thoracic Organ Transplantation and Malignancy
Lung Transplantation for Patients with Chronic GVHD Following Allogeneic Stem Cell Transplant
Presented by: Samuel Goldfarb
Concurrent Session 24: What’s New in Primary Graft Dysfunction Post Lung Transplantation
0214 – Plasma RIP3 Is Decreased in PGD after Lung Transplantation
Presented by: A. D’Errico, M. Hotz, E. Cantu, M. Porteous, M. Oyster, R. Shah, S. Arcasoy, L. Snyder, K. M. Wille, M. Hartwig, L. B. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, S. Kawut, S. Palmer, D. J. Lederer, J. D. Christie, N. Mangalmurti, J. M. Diamond
Concurrent Session 25: Beyond Adherence: What’s New Out There?
0221 – Medical Adherence in the Late-Term after Lung Transplant
Presented by: K. R. Fox, A. J. DeVito Dabbs, A. F. DiMartini, D. M. Posluszny, E. M. Rosenberger, J. M. Pilewski, M. A. Dew
Concurrent Session 27: Are Two Pumps Better Than One? RV Failure and MCS
0232 – Risk Factors Associated with Right Ventricular Assist Device Implantation: Insights from INTERMACS
Presented by: M. S. Kiernan, D. DeNofrio, D. T. Pham, N. K. Kapur, R. Ruthazer, E. W, J. E. Rame, P. Alturi, E. Y. Birati, S. L. Myers, G. H. Oliveira, J. K. Kirklin, R. L. Kormos, F. D. Pagani, J. J. Teuteberg
0234 – Chemokine Receptor Down Regulation in Mechanical Circulatory Support Patients with Right Ventricular Failure
Presented by: A. Nayak, T. N. Bachman, K. Hanley-Yanez, C. McTiernan, D. McNamara, R. L. Kormos, O. Hunter, A. Inashvili, L. Lagazzi, J. J. Teuteberg, M. A. Simon
Concurrent Session 34: How Much is Too Much? Assessing Risk Prior to MCS
0275 – Physician Prediction of Outcomes in Ambulatory Patients with Advanced Heart Failure
Presented by: M. M. Kittleson, C. B. Patel, R. S. Cantor, A. D. DeVore, A. V. Ambardekar, J. T. Thibodeau, L. M. Cadaret, S. V. Pamboukian, J. J. Teuteberg, R. C. Forde-McLean, M. M. Mountis, M. Palardy, G. C. Stewart, M. A. Hamilton
Concurrent Session 40: Too Much of a Good Thing: Balancing Benefit and Medication Complexity
0315 – Effect of Aerosolized Antipseudomonals on Pseudomonas Recurrence and Bronchiolitis Obliterans Syndrome after Lung Transplantation
Presented by: C. A. Moore, J. M. Pilewski, K. M. Robinson, M. R. Morrell, C. J. Gries, A. Zeevi, J. F. McDyer, C. R. Ensor
Mini Oral 07: Patient Management and Outcomes in MCS
0693 – When Antibiotics Are Not Enough: Frequency, Etiology and Durability of the Surgical Management of Driveline Infections
Presented by: M. Lander, L. Lagazzi, R. L. Kormos, G. O’Shea, S. Weaver T. Schweke, M. Shullo, J. J. Teuteberg
0326 – Log Files from the HVAD: What Can Daily and Long-Term Changes in Flow Tell Us about Patients?
Presented by: A. Potter, S. Anderson, J. J. Teuteberg, R. L. Kormos, J. Holtz
Mini Oral 09: Risk Factors and Lung Transplant Outcomes
0343 – Outcomes in Lung Transplant Recipients with Mycobacterium Abscessus Infection
Presented by: Y. Hamad, J. M. Pilewski, J. D’Cunha, E. J. Kwak
0351 – Interleukin 12-Dependent CMV-Specific CD4+ T Cell Proliferation, T-bet Induction and Effector Function During Primary Infection Are Key Determinants for Early Immune Control in Lung Transplant Recipients
Presented by: I. Popescu, M. R. Pipeling, H. Mannem, P. D. Shah, J. B. Orens, J. F. McDyer
Mini Oral 11: Models in Transplantation: From Mouse to Rat to Pig to Human
0369 – Cyclosporine A Can Mitigate Mitochondrial Dysfunction in Lung Grafts during Ex Vivo Lung Perfusion: A Potent Contributor for Better Preconditioning
Presented by: S. Haam, K. Noda, J. D’Cunha, J. D. Luketich, N. Shigemura
0477 – Circulating Cytokines vs. Leukocytes: A Therapeutic Target during Ex Vivo Lung Perfusion
Presented by: K. Noda, S. Haam, D. Zaldonis, J. D’Cunha, J. D. Luketich, N. Shigemura
Poster Session 3: Junior Faculty Case Reports
1237 – Pulmonary Kaposi’s Sarcoma after Lung Transplantation, with 2-Year Follow-Up
Presented by: J. Yoon, N. Shigemura, J. D’Cunha, M. Mehrad, M. Pipeling
Poster Session 3: Lung Transplantation
1026 – The Paradoxical Impact of Warm Ischemia on Lung Allograft Survival
Presented by: C. D. Odell, E. Chan, N. Shigemura, M. R. Morrell, M. M. Crespo, J. M. Pilewski, J. D. Luketich, J. D’Cunha
Poster Session 3: Mechanical Circulatory Support
1042 – A Novel Combined Endpoint Integrating Quality of Life Can Inform Decisions about VAD in Ambulatory Advanced Heart Failure
Presented by: G. C. Stewart, A. V. Ambardekar, M. M. Kittleson, M. Palardy, A. DeVore, J. T. Thibodeau, J. J. Teuteberg, L. M. Cadaret, R. C. Forde-McLean, M. M. Mountis, S. V. Pamboukian, R. Cantor, R. Xie, L. W. Stevenson
1056 – Characteristics of Non-Compliant (NC) LVAD Patients
Presented by: J. Larsen, E. M. Dunn, N. M. Kunz, K. L. Lockard, J. J. Teuteberg, L. Lagazzi, A. D. Althouse, R. L. Kormos
1083 – No Pulse, No Problem! Measuring Blood Pressure and Estimating Pulse Pressure in Centrifugal Flow Left Ventricular Assist Devices
Presented by: J. E. Holtz, A. N. Potter, B. C. Lampert, L. Lagazzi, R. L. Kormos, J. J. Teuteberg
Poster Session 3: Pediatrics
1126 – The Impact of Age on the Incidence and Prevalence of Moderate to Severe Cellular Rejection Detected by Routine Surveillance Biopsy in Pediatric Heart Transplantation
Presented by: M. D. Zinn, K. E. Simpson, M. J. Wallendorf, A. D. Osborne, J. K. Kirklin, C. E. Canter
1139 – Impact of Routine Surveillance Biopsy Intensity on the Diagnosis of Moderate to Severe Cellular Rejection and Survival After Pediatric Heart Transplantation
Presented by: M. D. Zinn, K. E. Simpson, M. J. Wallendorf, A. D. Osborne, J. K. Kirklin, C. E. Canter.
1152 – Pediatric Myocarditis in a Contemporary Multi-Center Cohort
Presented by: R. J. Butts, G. J. Boyle, S. Deshpande, K. Gambetta, K. Knecht, C. Prada Ruiz, M. Richmond, S. West, A. Lal
1155 – Pediatric Myocarditis: Variations in Immunotherapy and Impact on Outcomes
Presented by: K. Gambetta, G. J. Boyle, R. J. Butts, K. R. Knecht, A. K. Lal, Y. Law, A. Prada-Ruiz, M. E. Richmond, S. C. West, S. R. Deshpande
Poster Session 3: Pharmacy & Pharmacology
1175 – Tacrolimus Immunosuppressive Regimens Are Associated with a Mortality Benefit in Lung Transplantation Recipients at a High-Volume Single Center
Presented by: A. B. Lichvar, M. R. Morrell, J. Hayanga, J. M. Pilewski, M. M. Crespo, J. D’Cunha, A. Zeevi, J. F. McDyer, C. R. Ensor
1181 – Mycophenolate-Based Immunosuppressive Regimens Are Associated with a Mortality Benefit in Lung Transplantation Recipients at a Single High-Volume Center
Presented by: A. B. Lichvar, M. R. Morrell, J. Hayanga, J. M. Pilewski, M. M. Crespo, J. D’Cunha, A. Zeevi, J. F. McDyer, C. R. Ensor
Saturday, April 30
Concurrent Session 45: Pediatric Heart Failure
0412 – Risk Factors at Presentation Predict Outcomes of Pediatric Myocarditis: A Contemporary Multi-Center Cohort
Presented by: S. C. West, G. J. Boyle, R. J. Butts, S. R. Deshpande, K. Gambetta, K. R. Knecht, A. K. Lal, Y. Law, A. C. Prada-Ruiz, M. Richmond
Plenary Session – Pushing New Scientific Frontiers: It’s In Our Heritage
April 30, 2016, 9:45 AM – 11:45 AM
Co-Chair: Jeffrey J. Teuteberg
Lifetime Achievement Award to Adrian and Jean Kantrowitz
Presented by: Robert L. Kormos
Concurrent Session 48: Not Just to Survive, But to Thrive: Comprehensive Care of the MCS Patient
0435 – Substantial Reduction in Driveline Infection Rates with the Modification of Driveline Dressing Protocols
Presented by: M. Lander, N. Kunz, E. Dunn, K. Lockard, G. O’Shea, S. Weaver, T. Schweke, M. A. Shullo, L. Lagazzi, R. L. Kormos, J. J. Teuteberg
ISHLT Academy: Master Class in Mechanical Circulatory Support
SECTION B: Case Scenario: Chronic infection management on durable support and thromboembolic complication
Presented by: Robert L. Kormos
