Orthopaedic Surgeons Contribute to Course Lectures and Presentations at the MSIS 2022 Annual Meeting

The Musculoskeletal Infection Society (MSIS) hosted its 32^nd annual meeting August 5-6, 2022, in Pittsburgh, Pennsylvania. Several members of the UPMC Department of Orthopaedic Surgery attended and contributed to meaningful discussions, presentations, and lectures, including MSIS president and course director, Brian A. Klatt, MD, and Michael O’Malley, MD, who served on this year’s program committee. Learn more about their contributions below and view the full program of events.

Lectures and Presentations

Prospective ex vivo activity of PLG0206, an engineered antibacterial peptide, on chronic periprosthetic joint infection total knee arthroplasty components: the Knee Explant Analysis (KnEA) Study

Kimberly M. Brothers, PhD; Kenneth Urish, MD

Incidence of Unexpected Positive Sonication Results in Presumed Aseptic Knee and Hip Revision Arthroplasty

Alan Wilson, MD; Brian A. Klatt, MD; Michael O’Malley, MD; and F. Johannes Plate, MD

Kimberly M. Brothers, PhD; Peter Alexander, PhD; and Kenneth Urish, MD

• Development of a PJI microJoint Bioreactor for the study of Bacteriophage Activity
• An Engineered Antimicrobial Peptide, PLG0206, Reduces Biofilm Mass and Increases Survival in a Rabbit Model of Staphylococcus aureus Periprosthetic Joint Infection

Closed Incision Negative Pressure Therapy Reduces Incidence of Re-Operation for Surgical Site Infection in Spine Surgery

Anthony Oyekan, MD

Impact of Bacterial Phenotypic Variation with Bacteriophage therapy: A Pilot Study with Prosthetic Joint Infection Isolates

Kenneth Urish, MD

Low Friction Spacers for Two-Stage Exchange Show Decreased Bacterial Colonization Compared to Cement Molds and Static Spacers

Brandon Couch, MD; Alan Wilson, MD; Brian A. Klatt, MD; F. Johannes Plate, MD; and Michael O’Malley, MD

Symposium Presentations

Musculoskeletal Infection: Literature review of economic impact and advocacy issues

Brian A. Klatt, MD

ePosters

Pharmacokinetic Profile of 7-Day Local Irrigation of Vancomycin and Tobramycin for Treatment of Periprosthetic Joint Infection

Kenneth Urish, MD

Increased Surgical Site Subcutaneous Fat Thickness Is Associated with Infection after Lumbar Laminectomy with Instrumented Fusion

Anthony Oyekan, MD; Stephen Chen, MD; Melissa Tang, MD; Joon Y. Lee, MD; Jeremy D. Shaw, MD

High Mortality After Revision TKA for PJI is Related to Preoperative Morbidity and the Disease Process but Not Treatment

Nicholas P Drain, MD; Kenneth Urish, MD

Rate of Recurrent Infections and Implant Removal After Initial Debridement in Spine Surgery

Anthony Oyekan, MD; Brandon Couch, MD; Melissa Tang, MD; Joon Y. Lee, MD; Jeremy D. Shaw, MD

Kimberly M. Brothers, PhD; Kenneth Urish, MD

• The Engineered Antimicrobial Peptide, PLG0206, has Potent Biofilm and Planktonic Activity Against Multi-Drug Resistant ESKAPE Organisms
• Sub-Optimal Dosing of Vancomycin Increases Rates of Biofilm Formation and Surgical Infection in an Animal Model
• The Joint Microenvironment Decreases MRSA Resistance to Cefazolin
• mazEF toxin anti-toxin mediated regulation of Staphylococcus aureus biofilm growth and antibiotic tolerance
• Methicillin resistance in Staphylococcus aureus is media dependent

Session Moderators

Kenneth Urish, MD

Michael O’Malley, MD

Brian A. Klatt, MD

Abstract and Presentation Reviewers

F. Johannes Plate, MD