New Research Published on Role of Sirtuin 5 in Regulating Kidney Energy Metabolism

Sunder Sims-Lucas, PhD, division of pediatric nephrology, and Eric S. Goetzman, PhD, division of medical genetics, of UPMC Children’s Hospital of Pittsburgh, were recently published in the Journal of the American Society of Nephrology for their research titled, “Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.” 

While Sirtuin 5 (Sirt5) is known to reverse post-translational lysine acylation on multiple enzymes in fatty acid oxidation, its role in regulating kidney energy metabolism had yet to be defined. In this new study, researchers subjected Sirt5-deficient mice to two AKI models and assessed kidney function, injury, and fatty acid oxidation. 

Learn about their findings by reading the full study published in JASN.