UPMC Physicians and Researchers Presenting at American Association for the Study of Liver Diseases (AASLD) 2026 Meeting

October 23, 2026

Physicians and researchers from UPMC, UPMC Children’s Hospital of Pittsburgh, the University of Pittsburgh, and the Pittsburgh Liver Research Center will participate in The Liver Meeting^®, taking place Nov. 5 to 9, in Denver, Colorado.

The Pittsburgh Liver Research Center, the University of Pittsburgh Division of Gastroenterology, Hepatology and Nutrition, UPMC Transplant, and the UPMC Center for Liver Care will host a reception on Saturday, Nov. 7.

Throughout the meeting, UPMC and Pitt researchers will deliver nine unique presentations, and our faculty have contributed to more than 60 of the accepted abstracts.

Presentations and sessions featuring UPMC and Pitt researchers include:

Thursday, Nov. 5

Postgraduate Course, Parts 1–4: Advancing Hepatology—Breakthroughs Shaping Tomorrow’s Care 
8 am – 5 pm
General Session, Hall A
Moderator: Scott Biggins, MD, MAS, FAASLD

Hepatotoxicity SIG Poster Highlights
Environmental Co-Exposure to PFAS and Heavy Metals Creates a Clinically Relevant Pro-Tumorigenic Transcriptomic Signature in a Non-Tumor MASLD Mouse Model
2:43-2:48 pm
Summit 1, The Park @TLM, Hall D
Presenter: Haley Arbore, BS, BA

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Friday, Nov. 6

Real-World, Data-Driven Strategies to Improve Outcomes in Cirrhosis and Metabolic Disease
Electronic Medical Record–Based Strategies to Identify Steatotic Liver Disease and Operationalize Care Across the Metabolic Dysfunction–Associated Steatotic Liver Disease, Alcohol-Associated Liver Disease, and MetALD Spectrum
9-9:15 am
Bluebird Ballroom 2DEF
Presenter: Shari Rogal, MD, MPH, FAASLD

Our Livers in a Polluted Environment: Mechanisms and Clinical Implications
Exacerbation of Liver Disease by Vinyl Chloride
12-12:15 pm
Mile High Ballroom 2A-3A
Presenter: Juliane I. Beier, PhD

Beyond the Transplant: Innovation, Survival, and the Patient Journey
Leveling the Field: Access to Transplant
12-12:20 pm
Mile High Ballroom 4DEF
Presenter: Alison Faust, MD, MHS, FAASLD

From Words to Outcomes: Transforming Care for Alcohol Associated Liver Disease, Part 2
Strategies to Implement Alcohol Use Care at Your Center
2:45-3 pm
Bluebird Ballroom 1B
Presenter: Shari Rogal, MD, MPH, FAASLD

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Saturday, Nov. 7

American Association for the Study of Liver Diseases and the International Liver Transplantation Society Transplant Course, Parts 1–5
Re-Living Donor Liver Transplant After Living Donor Liver Transplant: Indications, Contraindications, and Outcomes
8:15-8:25 am
Bluebird Ballroom 3ABC
Presenter: Swaytha R. Ganesh, MD

American Association for the Study of Liver Diseases and the International Liver Transplantation Society Transplant Course, Parts 1–5
New Developments in Surveillance for Cholangiocarcinoma in Primary Sclerosing Cholangitis
9:55-10:05 am
Bluebird Ballroom 3ABC
Presenter: Adam Slivka, MD, PhD

Leveraging Electronic Health Record–Based, Real-World Data to Advance Hepatology and Liver Transplant Research and Clinical Care
Large-Scale Longitudinal Studies from an Integrated National EHR: Lessons from VA Hepatology Research
1:20-1:30 pm
Summit 4, The Park @TLM, Hall D
Presenter: Shari Rogal, MD, MPH, FAASLD

Abstracts presented by UPMC and Pitt researchers include:

0013 | QEL-001, AN ENGINEERED TREG CELL THERAPY TARGETING HLA-A2, DEMONSTRATES SAFETY, PHENOTYPIC STABILITY, DURABILITY AND FACILITATES MINIMIZATION OF IMMUNOSUPPRESSION IN LIVER TRANSPLANT PATIENTS (LIBERATE)

Alberto Sanchez-Fueyo¹ Kourosh Saeb-Parsy² Jacques Pirenne³ Jordi Colmenero⁴ Manuel Rodriguez-Peralvarez⁵ Anthony Demetris⁶ Andrew Lesniak⁶ Gareth Wright⁷ Annie Woodburne⁷ Sarah-Jayne Reilly⁷ Chris Sharpe⁷ Nikola Novcic⁷ Rupert Kenefect⁷ Anna Fettiplace⁷ Laurie Baylor Curtis⁸ Marc Martinez-Llordella⁷ Alan Magovern⁷ Nathalie Belmonte⁷ Kasia Averall⁷ Luke Devey⁷, ¹RW Institute of Liver Studies, Kings College London, ²University of Cambridge and NIHR Biomedical Research Centre, Cambridge, UK, ³University Hospitals Leuven, ⁴Liver Unit, Hospital Clinic Barcelona, Spain, ⁵Hospital Reina Sofia, Universidad de Cordoba, Spain, ⁶University of Pittsburgh, ⁷Quell Therapeutics Ltd, ⁸Quell Therapeutics

0040 | SEX DIFFERENCES IN ALCOHOL CONSUMPTION: A GLOBAL ANALYSIS OF PREVALENCE ESTIMATES AND DRINK DEFINITION HETEROGENEITY

Ximena Parraga¹ Denisse Rubio Cruz² Kriti Soni¹ Tulio Correa³ Hyundam (Dami) Gu¹ S. Fisher Rhoads¹ Vinay Jahagirdar¹ Kavin Parmar¹ Krishan Patel¹ Stephen Hoang¹ Luis Díaz⁴ Juan Pablo Arab¹, ¹Virginia Commonwealth University, ²Lahey Hospital, Virginia Commonwealth University, ³University of Pittsburgh, ⁴Pontificia Universidad Católica de Chile

0085 | IMPACT OF GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS (GLP-1 RA) ON METABOLIC DYSFUNCTION ASSOCIATED STEATOHEPATITIS (MASH) CIRRHOSIS

Olufunso Agbalajobi¹ Peng Yan² Claire Durkin³ Adeel Butt⁴ Obaid Shaikh⁵, ¹University of Pittsburgh Medical Center, ²VA Pittsburgh Healthcare Center, ³University of Pittsburgh School of Medicine, ⁴Hackensack Meridian Medical Group, ⁵VA Pittsburgh Healthcare System

0101 | IDENTIFYING AN OUTCOME-BASED LIVER FRAILTY INDEX CUTOFF TO DEFINE ROBUSTNESS AS A TARGET FOR FRAILTY INTERVENTION

Stephanie Zhang¹ Amy Shui² Avesh Thuluvath³ Andres Duarte-Rojo⁴ Daniel Ganger⁴ Elizabeth Verna³ Daniela Ladner⁵ Robert Rahimi⁶ Amit Tevar⁷ Elizabeth King⁸ Meredith Pearson⁹ Marwan Ghabril¹⁰ Matthew Kappus¹¹ Jennifer Lai¹², ¹School of Medicine, University of California-San Francisco, ²Department of Epidemiology and Biostatistics, University of California-San Francisco, ³Center for Liver Disease and Transplantation, Columbia University Irving Medical Center, ⁴Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern Medicine, ⁵Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, ⁶Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, ⁷Thomas E. Starzl Transplantation Institute, University of Pittsburgh, ⁸Department of Surgery, John Hopkins University School of Medicine, ⁹Division of Gastroenterology, University of Washington, ¹⁰Division of Gastroenterology and Hepatology, Indiana University, ¹¹Division of Gastroenterology and Hepatology, Duke University, ¹²Division of Gastroenterology and Hepatology, University of California-San Francisco

0102 | COGNITIVE IMPAIRMENT IS HIGHLY PREVALENT AFTER LIVER TRANSPLANTATION AND ASSOCIATED WITH PRE-TRANSPLANT FRAILTY

Kacey Berry¹ Fawzy Barry¹ Matthew Kappus² Andres Duarte-Rojo³ Daniel Ganger⁴ Daniela Ladner⁵ Avesh Thuluvath⁶ Elizabeth Verna⁷ Marwan Ghabril⁸ Elizabeth King⁹ Amit Tevar¹⁰ Amy Shui¹ Robert Rahimi¹¹ Meredith Pearson¹² Katherine Possin¹ Elena Tsoy¹ Lawren VandeVrede¹ Jennifer Lai¹, ¹University of California, San Francisco, ²Duke University, ³Northwestern Medicine, ⁴Northwestern Memorial Hospital, ⁵Northwestern University, ⁶Columbia University Irving Medical Center, ⁷Columbia University Medical Center, ⁸Indiana University, ⁹Johns Hopkins Medicine, ¹⁰University of Pittsburgh, ¹¹Baylor University Medical Center, ¹²University of Washington Medicine

0124 | HISPANIC/LATINO LIVER TRANSPLANT CANDIDATES HAVE LOWER ACCESS TO LIVING DONOR LIVER TRANSPLANTATION IN THE UNITED STATES: A NATIONAL COMPETING-RISK ANALYSIS

Tulio L Correa¹ Leandro Sierra² Ximena Parraga³ Luiz A Díaz⁴ Douglas Simonetto⁵ Juan Pablo Arab⁶, ¹University of Pittsburgh, ²Cleveland Clinic Foundation, ³Virginia Commonwealth University School of Medicine, ⁴Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, ⁵Mayo Clinic Rochester, ⁶Virginia Commonwealth University

0220 | LOSS OF BILIARY ADHERENS JUNCTIONS RESULTS IN PRIMARY SCLEROSING CHOLANGITIS-LIKE CHOLESTATIC INJURY

Vik Meadows¹ Yekaterina Krutsenko¹ Chang Kyung Kim¹ Zachary Cannova¹ Hiroki Inada¹ Jia-Jun Liu¹ Shuchang Liu¹ Minakshi Poddar¹ Sucha Singh¹ Satdarshan (Paul) Monga¹, ¹University of Pittsburgh

0242 | BLOOD CD8 TISSUE RESIDENT MEMORY-LIKE ENDOTYPES PERSIST THROUGHOUT DISEASE COURSE IN PATIENTS WITH ACTIVATED T-CELL PEDIATRIC ACUTE LIVER FAILURE

Tamir Diamond¹ Alyssa Baccarella² Catherine Chapin³ David Smith² Portia Kreiger² Sarah Henrickson² Niansheng Chu² Ezuka Ogbolu² Anna Banc-Husu⁴ Daniel Leung⁵ Amrita Narang⁶ Beth Carter⁷ Scott Elisofon⁸ Ryan Fischer⁹ Amber Hildreth¹⁰ Mike Leonis¹¹ Steven Lobritto¹² Saeed Mohammad¹³ Anna Peters¹⁴ Norberto Rodriguez-Baez¹⁵ Rene Romero¹⁶ David Rudnick¹⁷ James Squires¹⁸ Shikha Sundaram¹⁹ Kyla Tolliver²⁰ Pamela Valentino²¹ Zemin Su²² Valerie Durkalski-Mauldin²² Katie Neighbors²³ Simon Horslen²⁴ Kathleen Loomes¹ Estella Alonso³ Edward Behrens², ¹The Children's Hospital of Philadelphia, ²Children's Hospital of Philadelphia, ³Ann and Robert H. Lurie Children's Hospital of Chicago, ⁴Baylor College of Medicine, Texas Children's Hospital, ⁵Texas Children's Hospital, ⁶Stanford, ⁷Children's Hospital Los Angeles, ⁸Boston Childrens Hospital, ⁹Children's Mercy Kansas City, ¹⁰University of California San Diego, ¹¹Cleveland Clinic Children's Outpatient Center (R3), ¹²NY Presbyterian Hospital - Columbia University, ¹³Monroe Carell Jr. Children’s Hospital at Vanderbilt, ¹⁴Cincinnati Children's Hospital Medical Center, ¹⁵University of Texas Southwestern Medical Center, ¹⁶Emory University School of Medicine, ¹⁷Washington University Medical Center, ¹⁸Children's Hospital of Pittsburgh, ¹⁹Children's Hospital Colorado, ²⁰Indiana University School of Medicine, ²¹University of Washington, ²²Medical University of South Carolina, ²³Ann & Robert H. Lurie Children's Hospital of Chicago, ²⁴UPMC Children's Hospital of Pittsburgh

0243 | OUTCOMES BENCHMARKS IN PEDIATRIC AUTOIMMUNE LIVER DISEASE: A FOUNDATION AND A CHALLENGE FOR IMPROVEMENT FROM THE AUTOIMMUNE LIVER DISEASE NETWORK FOR KIDS (A-LINK)

Amy Taylor¹ Cyd Castro-Rojas¹ Karan Mudaliar¹ Mary Bauer¹ Catharine Whitacre¹ Mosab Alquraish¹ Mary Ayers² Nanda Kerkar³ Sakil Kulkarni⁴ Sindhu Pandurangi⁵ Katelyn Saarela⁶ Kyla Tolliver⁷ Alexander Weymann⁸ Shehzad Saeed⁹ Christine Browner¹⁰ Nicole Horton¹⁰ Fionna Kopp¹⁰ Jane Weyer¹⁰ Lorrie Williams¹⁰ James Squires¹¹ Alexander Miethke¹, ¹Cincinnati Children's Hospital Medical Center, ²UPMC Children's Hospital of Pittsburgh, ³Massachusetts General Brigham for Children, ⁴Washington University in St. Louis, ⁵UT Southwestern, Children's Medical Center Dallas, ⁶Seattle Children's Hospital, ⁷Indiana University, ⁸Nationwide Children's Hospital, ⁹Dayton Children's Hospital, ¹⁰A-LiNK Connections, ¹¹Children's Hospital of Pittsburgh

0267 | GENETIC ANALYSES OF 1,732 BILIARY ATRESIA CASES IDENTIFY NOVEL ETIOLOGIC RISK GENES IN DEVELOPMENTAL, CILIARY, AND CHOLESTATIC INJURY PATHWAYS

Ronnie Li¹ Stephen Hoang¹ Ramakrishnan Rajagopalan² Kathleen Loomes² Edgar Hernandez³ Alexander Miethke⁴ Rohit Kohli⁵ Benjamin Shneider⁶ Pamela Valentino⁷ Estella Alonso⁸ Jean Molleston⁹ Kasper Wang¹⁰ Simon Horslen¹¹ Philip Rosenthal¹² Ronald Sokol¹³ Binita Kamath¹⁴ John Magee¹⁵ Stephen Guthery¹⁶ Saul Karpen¹ ChiLDReN Childhood Liver Disease Research Network¹⁷, ¹VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, ²The Children's Hospital of Philadelphia, ³University of Utah, ⁴Cincinnati Children's Hospital Medical Center, ⁵Children's Hospital Los Angeles, ⁶Texas Children's Hospital, ⁷University of Washington, ⁸Ann and Robert H. Lurie Children's Hospital of Chicago, ⁹Riley Hospital for Children, ¹⁰Hospital for Sick Children, ¹¹UPMC Children's Hospital of Pittsburgh, ¹²University of California, San Francisco, ¹³University of Colorado School of Medicine, ¹⁴Children's Hospital of Philadelphia, ¹⁵University of Michigan Hospitals and Health Centers, ¹⁶Intermountain Primary Children's Hospital, ¹⁷NIH NIDDK

0270 | EARLY TIMEPOINTS ARE CRITICAL IN BILIARY ATRESIA: RESULTS FROM PROSPECTIVELY FOLLOWING 831 INFANTS RECEIVING THE KASAI PORTOENTEROSTOMY

Sanjiv Harpavat¹ Sindhu Pandurangi² Steve Guthery³ Saul Karpen⁴ Kathleen Loomes⁵ Estella Alonso⁶ Simon Horslen⁷ Rohit Kohli⁸ John Magee⁹ Alexander Miethke¹⁰ Jean Molleston¹¹ Philip Rosenthal¹² Pamela Valentino¹³ Kasper Wang¹⁴ Ronald Sokol¹⁵ Benjamin Shneider¹⁶ the Childhood Liver Disease Research Network (ChiLDReN)¹⁷, ¹Texas Children's Liver Center - Baylor College of Medicine, ²UT Southwestern, Children's Medical Center Dallas, ³Primary Children's Hospital, ⁴VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, ⁵The Children's Hospital of Philadelphia, ⁶Ann and Robert H. Lurie Children's Hospital of Chicago, ⁷UPMC Children's Hospital of Pittsburgh, ⁸Children's Hospital Los Angeles, ⁹University of Michigan Hospitals and Health Centers, ¹⁰Cincinnati Children's Hospital Medical Center, ¹¹Riley Hospital for Children and Indiana University School of Medicine, ¹²University of California, San Francisco, ¹³University of Washington, ¹⁴Hospital for Sick Children, University of Toronto, ¹⁵University of Colorado School of Medicine, ¹⁶Texas Children's Hospital and Baylor College of Medicine, ¹⁷NIDDK

1001 | A STABILIZED FORM OF β-CATENIN FACILITATES HEPATOCYTE-TO-CHOLANGIOCYTE TRANSDIFFERENTIATION IN AN ORGANOID MODEL AND IMPROVES INJURY IN A MOUSE MODEL OF CHOLESTATIC LIVER DISEASE

Tony (Chun-Cheng) Chiang¹ Pamela Cornuet¹ Kari Nejak-Bowen¹, ¹University of Pittsburgh

1004 | DECREASED YAP/TAZ COPY NUMBER LEADS TO TARGETED SMALL BILE DUCT LOSS

Laura Molina¹ Jia-Jun Liu² Shuchang Liu³ Adelya Gabdulkhakova⁴ Sungjin Ko³ Satdarshan (Paul) Monga³ Kari Nejak-Bowen³, ¹University of Pittsburgh Medical Center, ²University of Pittsburgh School of Medicine, ³University of Pittsburgh, ⁴University of Heidelberg

1033 | TRANSCRIPTIONAL PROFILING OF THE MATERNAL LIVER ACROSS THE REPRODUCTIVE CYCLE REVEALS COORDINATED PROGRAMS OF GESTATIONAL GROWTH AND POSTPARTUM INVOLUTION

Anisha Jain¹ Satdarshan (Paul) Monga¹ Jia-Jun Liu¹ Silvia Hu¹, ¹University of Pittsburgh

1054 | MZB1 LOSS DISRUPTS EARLY TRANSCRIPTIONAL REPROGRAMMING OF METABOLIC, PROLIFERATIVE, AND STRESS-RESPONSE GENE NETWORKS DURING LIVER REGENERATION

Jiang Li¹ Noriko Kitano¹ Lorien Walker¹ Sudrishti Chaudhary¹ Jia-Jun Liu¹ Silvia Liu¹ Juliane Beier¹ Oliver Eickelberg¹ Marta Bueno¹ Gavin Arteel¹, ¹University of Pittsburgh

1071 | COMPUTATIONAL PATHOLOGY OUTPERFORMS CLINICAL AND MOLECULAR PROGNOSTIC MARKERS AND REVEALS TARGETABLE MORPHOLOGIC PHENOTYPES IN HEPATOCELLULAR CARCINOMA

Tyler Yasaka¹ Shaila Afrin² Junyan Tao¹ Po-Yuan Chen¹ Chang Kyung Kim¹ Anisha Jain¹ Laura Molina³ Rebekah Dadey¹ Riyue Bao¹ Satdarshan (Paul) Monga³ Yu-Chiao Chiu¹, ¹University of Pittsburgh School of Medicine, ²University of Pittsburgh School of Medicine, ³University of Pittsburgh

1118 | GUT MICROBIOME ALTERATIONS ARE ASSOCIATED WITH HEPATIC FIBROSIS IN PEOPLE WITH HIV

Maria Duarte¹ Bradley Aouizerat² Robert Burk³ Phyllis Tien¹ Steven Wolinsky⁴ Mallory Witt⁵ Yue Chen⁶ Chloe Thio⁷ Svenja Albrecht⁸ Seble Kassaye⁹ Margaret Fischl¹⁰ Deborah Gustafson¹¹ Cecile Lahiri¹² Michelle Floris-Moore¹³ Eric Seaberg¹⁴ Audrey French¹⁵ Jennifer Price¹, ¹University of California, San Francisco, ²New York University, ³Albert Einstein College of Medicine, ⁴Northwestern University Feinberg School of Medicine, ⁵David Geffen School of Medicine at UCLA / Harbor-UCLA Medical Center, ⁶University of Pittsburgh School of Medicine, ⁷Johns Hopkins University, ⁸University of Mississippi Medical Center, ⁹Georgetown University, ¹⁰University of Miami Miller School of Medicine, ¹¹SUNY Downstate Health Sciences University, ¹²Emory University School of Medicine, ¹³University of North Carolina at Chapel Hill, ¹⁴Johns Hopkins Bloomberg School of Public Health, ¹⁵Cook County Health

1123 | TRANSCRIPTIONAL UPREGULATION OF MICROBIAL MUCIN GLYCAN DEGRADATION IN THE GUT MICROBIOME OF NON-CIRRHOTIC PORTAL HYPERTENSION

Wesam Aleyadeh¹ Jenna Oringher² Meital Gewirtz³ Yue Zhang⁴ Neelam Redekar⁵ James Haddad⁶ Rownock Afruza⁷ Moumita Chakraborty⁷ Julian Hercun⁸ Maria Mironova⁹ Justin Lack⁴ David Kleiner¹⁰ Michail Lionakis¹¹ Christopher Koh⁷ Theo Heller¹², ¹National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, ²University of Pittsburgh & Carnegie Mellon University, ³Northwestern University Feinberg School of Medicine, ⁴NIH, ⁵NIAID/NIH, ⁶University of Wisconsin, ⁷NIDDK, NIH, ⁸Centre hospitalier de l'Universite de Montreal, ⁹UCSD, ¹⁰National Cancer Institute, Bethesda, ¹¹NIAID, NIH, ¹²NIH/NIDDK

1321 | TARGETED DELETION OF HEPATOCYTE ERBB3 ATTENUATES MASLD PROGRESSION AND REPROGRAMS THE PPARΓ–HNF4Α METABOLIC AXIS

Shehnaz Bano¹ Joseph Locker¹ Shirish Paranjpe¹ Rodrigo Florentino¹ Alejandro Soto-Gutierrez¹ George Michalopoulos¹ Bharat Bhushan¹, ¹University of Pittsburgh

1421 | IMPAIRED BASELINE KIDNEY FUNCTION IN PATIENTS WITH ACUTE HEPATIC PORPHYRIA ENROLLED IN THE PHASE 3 ENVISION STUDY

Desmond Murphy¹ Akshata Moghe² Paolo Ventura³ Rebecca Leaf⁴ John Quigley⁵ Penelope Stein⁶ Weiming Du¹ Eliane Sardh⁷Bruce Wang⁸ Roy Smith⁹, ¹Alnylam Pharmaceuticals, Cambridge, MA, USA, ²University of Texas Health Science Center at Houston, Houston, TX, USA, ³Internal Medicine Unit, University of Modena and Reggio Emilia, Modena, Italy, ⁴Center for Hematology, Mass General Brigham Cancer Institute, Boston, MA, ⁵University of Illinois College of Medicine, Chicago, IL, USA, ⁶Haematological Medicine, King’s College Hospital, London, UK, ⁷Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden, ⁸University of California San Francisco, San Francisco, CA, USA, ⁹University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

1475 | STROOP-DEFINED MINIMAL HEPATIC ENCEPHALOPATHY IS STABLE AND RESPONSIVE TO CLINICAL EVENTS IN A MULTI-CENTER CIRRHOSIS COHORT

Vinay Jahagirdar¹ Scott Silvey² Dan Park¹ Ali Khan¹ K Rajender Reddy³ Puneeta Tandon⁴ Jennifer Lai⁵ Jacqueline O'Leary⁶ Florence Wong⁷ Guadalupe Garcia-Tsao⁸ Hugo Vargas⁹ Philip Vutien¹⁰ Scott Biggins¹¹ Brian Bush¹ Jasmohan Bajaj¹², ¹Virginia Commonwealth University, Richmond, VA, ²Virginia Commonwealth Universtiy, Richmond, VA, ³University of Pennsylvania, Philadelphia, PA, ⁴University of Alberta, ⁵University of California, San Francisco, CA, ⁶UT Southwestern Medical Center, North Texas VA Health Care System, Dallas, TX, ⁷University of Toronto, ⁸Yale School of Medicine, New Haven, CT, ⁹Mayo Clinic Arizona, Scottsdale, AZ, ¹⁰University of Washington, Seattle, WA, ¹¹University of Pittsburgh, Pittsburgh, PA, ¹²Virginia Commonwealth University

1581 | BETA-BLOCKER UTILIZATION IN U.S. VETERANS WITH CIRRHOSIS AND CLINICALLY SIGNIFICANT PORTAL HYPERTENSION

Claire Durkin¹ Vera Yakovchenko² Patrick Spoutz³ Sumedha Chhatre⁴ Shari Rogal¹, ¹University of Pittsburgh, ²VA Pittsburgh Healthcare System, ³U.S. Department of Veterans Affairs, ⁴Philadelphia Corporal Michael J. Crescenz VA Medical Center

1590 | PREDICTORS OF SEVERE FALLS IN A MULTICENTER NORTH AMERICAN COHORT OF OUTPATIENTS WITH CIRRHOSIS

Puneeta Tandon¹ Jacqueline O'Leary² Jennifer Lai³ K Rajender Reddy⁴ Florence Wong⁵ Guadalupe Garcia-Tsao⁶ Scott Biggins⁷ Philip Vutien⁸ Hugo Vargas⁹ Patrick Kamath¹⁰ Ana Teresa Limon-Miro¹ Brian Bush¹¹ Scott Silvey¹¹ Jasmohan Bajaj¹¹, ¹University of Alberta, ²Dallas VA Medical Center, ³University of California San Francisco, ⁴University of Pennsylvania, ⁵University of Toronto, ⁶Yale University, ⁷University of Pittsburgh, ⁸University of Washington, ⁹Mayo Clinic Arizona, ¹⁰Mayo Clinic, Rochester, ¹¹Virginia Commonwealth University

1618 | PLATELET COUNT <135/MM³ PREDICTS SBP RECURRENCE ON SECONDARY SBP PROPHYLAXIS IN A NATIONAL CIRRHOSIS COHORT

Scott Silvey¹ Nilang Patel¹ Jacqueline O'Leary² Heather Patton³ Sofia Jakab⁴ Timothy Morgan⁵ Shari Rogal⁶Jasmohan Bajaj⁷, ¹VCU, ²UTSW, ³VA San Diego Healthcare, ⁴Yale University, ⁵VA Long Beach Healthcare System, ⁶University of Pittsburgh, ⁷Virginia Commonwealth University

1639 | ALTERED COGNITION AND PATIENT-REPORTED OUTCOMES PREDICT 1-YEAR HOSPITALIZATION RISK IN A MULTI-CENTER OUTPATIENT CIRRHOSIS COHORT

Jasmohan Bajaj¹ Jacqueline O'Leary² Jennifer Lai³ Puneeta Tandon⁴ Florence Wong⁵ Guadalupe Garcia-Tsao⁶ Scott Biggins⁷ Philip Vutien⁸ Patrick Kamath⁹ Hugo Vargas¹⁰ Scott Silvey¹¹ Brian Bush¹¹ K Rajender Reddy¹², ¹Virginia Commonwealth University, ²UTSW, ³UCSF, ⁴University of Alberta, ⁵University of Toronto, ⁶Yale University, ⁷UPMC, ⁸UW, ⁹Mayo Rochester, ¹⁰Mayo Clinic Arizona, ¹¹VCU, ¹²University of Pennsylvania

2058 | PREDICTION OF ACLF DEVELOPMENT IN A MULTI-CENTER OUTPATIENT CIRRHOSIS COHORT ACROSS NORTH AMERICA

Jasmohan Bajaj¹ Jacqueline O'Leary² Jennifer Lai³ Puneeta Tandon⁴ Patrick Kamath⁵ Hugo Vargas⁶ Philip Vutien⁷ Guadalupe Garcia-Tsao⁸ Scott Biggins⁹ Daniela Goyes⁸ Jawaid Shaw¹⁰ Dorothea Kent³ Tahira Shaikh¹¹ Katharina Staufer¹² Haley Obolewicz¹³ Stephanie Tsai¹⁴ Kaitlyn Wethey¹⁵ Brian Bush¹⁰ Florence Wong¹⁶ Scott Silvey¹⁰ K Rajender Reddy¹⁷, ¹Virginia Commonwealth University, ²Dallas VAMC, ³UCSF, ⁴University of Alberta, ⁵Mayo Clinic Rochester, ⁶Mayo Clinic Arizona, ⁷University of Washington, ⁸Yale University, ⁹University of Pittsburgh, ¹⁰VCU, ¹¹U Alberta, ¹²VCU and Genfit, ¹³Richmond VAMC, ¹⁴UTSW, ¹⁵U Penn, ¹⁶University of Toronto, ¹⁷University of Pennsylvania

2142 | HEALTH OUTCOMES IN SEXUAL AND GENDER MINORITY POPULATIONS WITH CHRONIC LIVER DISEASE: A SYSTEMATIC REVIEW

Kamalpreet S. Hara¹ Tulio Correa² Alberto Calleri¹ Sonali Paul³ Alexandra Strauss⁴ Nikki Duong⁵ Victor Chedid¹ Douglas Simonetto¹, ¹Mayo Clinic Rochester, ²University of Pittsburgh, ³University of Chicago Medical Center, ⁴Johns Hopkins School of Medicine, ⁵Stanford University

2198 | CAREGIVER PERSPECTIVES ON END-OF-LIFE CARE FOR VETERANS WITH CIRRHOSIS: A QUALITATIVE ANALYSIS OF THE VA BEREAVED FAMILY SURVEY

Kanika Malani¹ Tulio Correa² Olivia Belliveau³ Ramsey Cheung⁴ Neha Jakhete⁵ Sofia Jakab⁶ Catherine Mezzacappa³ Anna Nobbe⁷ Jacqueline O'Leary⁸ Shari Rogal² Anne Walling⁹ Karleen Giannitrapani¹⁰ Tamar Taddei⁶ Arpan Patel⁹, ¹Yale New Haven Hospital, ²University of Pittsburgh, ³Yale School of Medicine, ⁴Stanford University Medical Center, ⁵University of Maryland, ⁶VA Connecticut Healthcare System, ⁷VA Cincinnati Healthcare System, ⁸VA North Texas Healthcare System, ⁹VA Greater Los Angeles Healthcare System, ¹⁰VA Palo Alto Healthcare System

2200 | RISK STRATIFICATION FOR MAJOR ADVERSE LIVER OUTCOMES IN THE VETERANS HEALTH ADMINISTRATION SYSTEM USING FIB-4 VERSUS SAFE SCORES

George Ioannou¹ Shari Rogal² Prowpanga Udompap³ Heather Patton⁴ Sumedha Chhatre⁵ Patrick Spoutz⁶ W. Ray Kim⁷ Timothy Morgan⁸, ¹University of Washington, ²University of Pittsburgh, ³Minneapolis VA Medical Center, ⁴VA San Diego Healthcare, ⁵University of Pennsylvania, ⁶Boise VA Medical Center, ⁷Mayo Clinic Arizona, ⁸VA Long Beach Healthcare System

2203 | EXPERIENCES WITH VETERANS ADMINISTRATION AND COMMUNITY-BASED TRANSPLANT CARE FOLLOWING THE MISSION ACT

Claire Durkin¹ Nicole Beyer² Kristina Hruska² Anne-Marie Sheilds² Maria Mor² Michael Fine³ Steven Weisbord⁴ Shari Rogal¹, ¹University of Pittsburgh, ²VA Pittsburgh Healthcare System, ³University of PIttburgh, VA Pittsburgh Healthcare System, ⁴University of Pittsbugh, VA Pittsburgh Healthcare System

2244 | SYMPTOM CLUSTERS AND 90-DAY HOSPITALIZATION RISK IN ADVANCED LIVER DISEASE

Brittany Bromfield¹ Elizabeth Aby² Melanie Hundt³ Jonathan Rice⁴ Mike Kriss⁴ Kali Zhou³ Lauren Nephew⁵ Sarah Lieber⁶ Alvaro Noriega Ramirez⁶ Brett Fortune⁷ Clara Tow⁷ Paola Mejia⁷ Deepika Devuni⁸ Anita Krisharao⁸ Shari Rogal⁹ Stela Celaj⁹ Alan Noll¹⁰ Nathaly Cortez Bazan¹¹ Patricia Jones¹² Hersh Shroff¹² Krista Hunt¹² Areej Mazhar¹³ Dempsey Hughes¹³ Jackie Henson¹⁴ Lindsay King¹⁴ Thomas Leventhal² Enya Zhu¹⁴ Grace Bizup¹⁵ William Munroe¹⁵ Lina Nurhussien¹⁵ Nora Horick¹⁵ Chengbo Zeng¹⁶ Nneka Ufere¹⁵, ¹Brigham and Women's hospital, ²University of Minnesota, ³University of Southern California, ⁴University of Colorado, ⁵Indiana University, ⁶University of Texas Southwestern, ⁷Montefiore Einstein Center for Transplantation, ⁸University of Massachusetts, ⁹University of Pittsburgh, ¹⁰Tufts, ¹¹University of Miami, ¹²University of North Carolina, ¹³Northwestern University, ¹⁴Duke University, ¹⁵Massachusetts General Hospital, ¹⁶Patient Reported Outcomes, Value and Experience (PROVE) Center, Department of Surgery

2271 | SPATIAL TRANSCRIPTOMIC ANALYSIS OF PORTAL INFLAMMATION DIFFERENTIATES ACTIVATED T CELL PEDIATRIC ACUTE LIVER FAILURE FROM AUTOIMMUNE HEPATITIS

Tamir Diamond¹ Alyssa Baccarella¹ Catherine Chapin² David Smith¹ Sarah McCuaig³ Portia Kreiger¹ Ezuka Ogbolu¹ Anna Banc-Husu⁴ Daniel Leung⁵ Amrita Narang⁶ Beth Carter⁷ Scott Elisofon⁸ Ryan Fischer⁹ Amber Hildreth¹⁰ Mike Leonis¹¹ Steven Lobritto¹² Saeed Mohammad¹³ Anna Peters¹⁴ Norberto Rodriguez-Baez¹⁵ Rene Romero¹⁶ David Rudnick¹⁷ James Squires¹⁸ Shikha Sundaram¹⁹ Kyla Tolliver²⁰ Pamela Valentino²¹ Zemin Su²² Valerie Durkalski-Mauldin²² Katie Neighbors²³ Simon Horslen²⁴ Kathleen Loomes¹ Estella Alonso² Edward Behrens¹, ¹The Children's Hospital of Philadelphia, ²Ann and Robert H. Lurie Children's Hospital of Chicago, ³Children's Hospital of Philadelphia, ⁴Baylor College of Medicine, Texas Children's Hospital, ⁵Texas Children's Hospital, ⁶Stanford, ⁷Children's Hospital Los Angeles, ⁸Boston Childrens Hospital, ⁹Children's Mercy Kansas City, ¹⁰University of California San Diego, ¹¹Cleveland Clinic Children's Outpatient Center (R3), ¹²NY Presbyterian Hospital - Columbia University, ¹³Monroe Carell Jr. Children’s Hospital at Vanderbilt, ¹⁴Cincinnati Children's Hospital Medical Center, ¹⁵University of Texas Southwestern Medical Center, ¹⁶Children's Healthcare of Atlanta, ¹⁷Washington University Medical Center, ¹⁸Children's Hospital of Pittsburgh, ¹⁹Children's Hospital Colorado, ²⁰Indiana University, ²¹University of Washington, ²²Medical University of South Carolina, ²³Ann & Robert H. Lurie Children's Hospital of Chicago, ²⁴UPMC Children's Hospital of Pittsburgh

2533 | LIMITED ADOPTION OF MET-ALD AS A DIAGNOSIS FOR LIVER TRANSPLANTATION

Previn Ganesan¹ Scott Biggins² Kymberly Watt³ Neil Shah⁴ Allison Kwong⁵, ¹Stanford University, ²University of PIttsburgh, ³Mayo Clinic, ⁴University of North Carolina at Chapel Hill, ⁵Stanford University Medical Center

2544 | IMPACT OF DIETARY PROFILE AND BODY COMPOSITION ON RISK OF FIBROSIS IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE

Ozge Ozgur¹ Renwei Wang¹ Jian-Min Yuan¹ Jaideep Behari¹, ¹University of Pittsburgh Medical Center

2651 | RESPONSIVENESS OF PATIENTS WITH BILE SALT EXPORT PUMP DEFICIENCY TO THERAPEUTIC INTERRUPTION OF THE ENTEROHEPATIC CIRCULATION ALLOWS FURTHER DETAILING OF GENOTYPE-PHENOTYPE RELATIONSHIPS

Mark Nomden¹ Alise de Groot¹ Elizabeth Bannister¹ Antonia Felzen² Pedro Miranda-Afonso³ Richard Thompson⁴ Emmanuel Gonzales⁵ Irena Jankowska⁶ Etienne Sokal⁷ Benjamin Shneider⁸ Seema Alam⁹ Cigdem Arikan¹⁰ Henrik Arnell¹¹ Madeleine Aumar¹² Amer Azaz¹³ Emna Barkaoui¹⁴ María Belén Pallitto¹⁵ Marisa Beretta¹⁶ Jernej Brecelj¹⁷ Dieter Broering¹⁸ Pier Luigi Calvo¹⁹ Mara Cananzi²⁰ Huey-Ling Chen²¹ Guillermo Costaguta²² Piotr Czubkowski²³ Lorenzo D'Antiga²⁴ Elisa Carvalho²⁵ Dominique Debray²⁶ Antal Dezsőfi-Gottl²⁷ Angelo Di Giorgio²⁸ Ozlem Durmaz²⁹ Alexandre Fabre³⁰ Sandra Ferreira³¹ Ryan Fischer³² Björn Fischler³³ Teresa Botelho³¹ Tanja Fritz³⁴ Cristina Gonçalves³⁵ Enke Grabhorn³⁶ Tassos Grammatikopoulos³⁷ Girish Gupte³⁸ Winita Hardikar³⁹ Loreto Hierro⁴⁰ Giuseppe Indolfi⁴¹ Emmanuel Jacquemin⁵ Giulia Jannone⁷ Carolina Jimenez-Rivera⁴² Marianne Hørby Jørgensen⁴³ Binita Kamath⁴⁴ Wikrom Karnsakul⁴⁵ Nanda Kerkar⁴⁶ Kyung Mo Kim⁴⁷ Jae Sung Ko⁴⁸ Denitza Kofinova⁴⁹ Nolwenn Laborde⁵⁰ Zhongdie Li⁵¹ Patryk Lipinski⁵² Rohan Malik⁵³ Saeed Mohammad⁵⁴ Yael Mozer-Glassberg⁵⁵ Gema Muñoz Bartolo⁴⁰ Gabriella Nebbia⁵⁶ Felipe Ordonez-Guerrero⁵⁷ Anna Orłowska⁶ Arti Pawaria⁵⁸ Tudor Pop⁵⁹ Jesus Quintero Bernabeu⁶⁰ Giusy Ranucci⁶¹ Aathira Ravindranath⁶² Nathalie Rock⁶³ Maria Rogalidou⁶⁴ Ioannis Roilidis⁶⁵ Mathias Ruiz⁶⁶ Thomas Sandahl⁶⁷ Srinivas Sankaranarayanan⁶⁸ Mohammad Shagrani¹⁸ Eyal Shteyer⁶⁹ Pooja Reddy Spector⁷⁰ James Squires⁷¹ Ekkehard Sturm⁷² Emanuele Nicastro²⁴ Cristina Targa Ferreira⁷³ Marise Tofoli⁷⁴ Bethany Tucker³⁷ Christos Tzivinikos⁷⁵ Wendy van der Woerd⁷⁶ Georg Friedrich Vogel⁷⁷ Heng Wang⁷⁸ Jian-She Wang⁵¹ Sabina Wiecek⁷⁹ Aglaia Zellos⁸⁰ Andreanne Zizzo⁸¹ Bettina Hansen⁸² Paola Mian⁸³ Henkjan Verkade⁸³, ¹University of Groningen, University Medical Center Groningen, ²Pediatric Gastroenterology and Hepatology, University Medical Center Groningen, ³Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, ⁴King's College London, ⁵Hopital Bicetre, ⁶Children's Memorial Health Institute, Warsaw, ⁷Université Catholique de Louvain, Cliniques St Luc, Brussels, ⁸Texas Children's Hospital, ⁹Institute of Liver and Biliary Sciences, ¹⁰Koc University School of Medicine, Istanbul, ¹¹Astrid Lindgren Children's Hospital, Karolinska University Hospital & Karolinska Institutet, ¹²Lille University Hospital, Lille, ¹³Sheikh Khalifa Medical City, Abu Dhabi, ¹⁴Tunis Children Hospital, Tunis, ¹⁵Hospital Italiano, CABA, ¹⁶Wits Donald Gordon Medical Centre, University of the Witwatersrand, ¹⁷University Children’s Hospital Ljubljana, ¹⁸King Faisal Specialist Hospital & Research Center, Riyadh, ¹⁹Regina Margherita Children’s Hospital, ²⁰University of Padova, ²¹National Taiwan University, ²²CHU de Quebec-Université Laval, Quebec City, ²³The Children's Memorial Health Institute, ²⁴Hospital Papa Giovanni XXIII, Bergamo, ²⁵Hospital de Base do Distrito Federal, Hospital da Criança de Brasília, ²⁶APHP-Necker Enfants Malades University Hospital, Paris, ²⁷Semmelweis University, Budapest, ²⁸University of Udine, Udine, ²⁹Istanbul University Istanbul Medical Faculty, ³⁰Hôpital de la Timone Enfant,Marseille, ³¹Unidade Local de Saúde Coimbra, Coimbra, ³²Children's Mercy Kansas City, ³³Astrid Lindgren Children's Hospital, Karolinska University Hospital, ³⁴University Children's Hospital Tübingen, Tübingen, ³⁵Pediatric Gastroenterology/Hepatology Center Lisbon, Lisbon, ³⁶University Medical Center Hamburg Eppendorf, Hamburg, ³⁷King's College Hospital, ³⁸Birmingham Women’s and Children’s Hospital, Birmingham, ³⁹Royal Children's Hospital, ⁴⁰Children’s Hospital La Paz, La Paz University Hospital, Madrid, ⁴¹Meyer Children’s Hospital, IRCCS, Florence, ⁴²Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ⁴³Rigshospitalet Copenhagen University Hospital, Copenhagen, ⁴⁴Children's Hospital of Philadelphia, ⁴⁵Johns Hopkins University, ⁴⁶Massachusetts General Brigham for Children, ⁴⁷Asan Medical Center Children’s Hospital, Seoul, ⁴⁸Seoul National University College of Medicine, Seoul, ⁴⁹University Multiprofile Hospital for Active Treatment and Emergency Medicine “N.I. Pirogov”, Sofia, ⁵⁰Hôpital des Enfants, CHU de Toulouse, Toulouse, ⁵¹Children's Hospital of Fudan University, Shanghai, ⁵²Center of Postgraduate Medical Education, Dziekanów Leśny, ⁵³All India Institute of Medical Sciences, New Delhi, ⁵⁴Monroe Carell Jr. Children's Hospital & Vanderbilt University School of Medicine, ⁵⁵Schneider Children’s Medical Center of Israel, Petah Tikva, ⁵⁶Fondazione Irccs Ca’ Granda Ospedale Maggiore Policlinico, Milano, ⁵⁷Fundación Cardioinfantil, Bogotá, ⁵⁸Amrita Institute of Medical Sciences, ⁵⁹Iuliu Hatieganu University of Medicine and Pharmacy, ClujNapoca, ⁶⁰Hospital Universiatri Vall d’Hebron, Barcelona, ⁶¹Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, ⁶²Apollo BGS Hospital, Mysuru, Karnataka, ⁶³University Hospital Geneva, ⁶⁴Agia Sophia Children’s Hospital, National and Kapodistrian University of Athens, ⁶⁵Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, ⁶⁶Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, ⁶⁷Aarhus University Hospital, ⁶⁸Kanchi Kamakoti Childs Trust Hospital, Chennai, ⁶⁹Shaare Zedek Medical Center, Jerusalem, ⁷⁰Columbia University Irving Medical Center, New York, ⁷¹Children's Hospital of Pittsburgh, ⁷²Universitats Klinikum Tubingen, ⁷³Hospital da Criança Santo Antônio, ⁷⁴State Hospital for Children and Adolescents, Goiania, ⁷⁵Al Jalila Children’s Specialty Hospital, Dubai, ⁷⁶Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, ⁷⁷Medical University of Innsbruck, Innsbruck, ⁷⁸DDC Clinic for Special Needs Children, Middlefield, ⁷⁹Medical University of Silesia, Katowice, ⁸⁰Mitera Children's Hospital, Athens, ⁸¹London Children's Hospital, Western University, London, Ontario, Canada, ⁸²Erasmus Medical Center, Rotterdam & University of Toronto, ⁸³University Medical Center Groningen, Groningen

2652 | THE END OF THE DISCUSSION: SURGICAL BILIARY DIVERSION AND LIVER TRANSPLANTATION INDUCE CATCH-UP GROWTH IN BSEP DEFICIENCY, BUT NOT IN FIC1 DEFICIENCY

Alise de Groot¹ Elizabeth Bannister² Mark Nomden³ Richard Thompson⁴ Benjamin Shneider⁵ Emmanuel Gonzales⁶ Irena Jankowska⁷ Etienne Sokal⁸ Seema Alam⁹ Cigdem Arikan¹⁰ Henrik Arnell¹¹ Madeleine Aumar¹² Amer Azaz¹³ Emna Barkaoui¹⁴ María Belén Pallitto¹⁵ Marisa Beretta¹⁶ Teresa Botelho¹⁷ Jernej Brecelj¹⁸ Dieter Broering¹⁹ Pier Luigi Calvo²⁰ Mara Cananzi²¹ Huey-Ling Chen²² Guillermo Costaguta²³ Piotr Czubkowski²⁴ Lorenzo D'Antiga²⁵ Elisa de Carvalho²⁶ Dominique Debray²⁷ Antal Dezs?fi²⁸ Angelo Di Giorgio²⁹ Ozlem Durmaz³⁰ Alexandre Fabre³¹ Ryan Fischer³² Björn Fischler³³ Tanja Fritz³⁴ Cristina Gonçalves³⁵ Enke Grabhorn³⁶ Tassos Grammatikopoulos³⁷ Girish Gupte³⁸ Winita Hardikar² Loreto Hierro³⁹ Giuseppe Indolfi⁴⁰ Emmanuel Jacquemin⁴¹ Giulia Jannone⁸ Carolina Jimenez-Rivera⁴² Marianne Hørby Jørgensen⁴³ Binita Kamath⁴⁴ Wikrom Karnsakul⁴⁵ Nanda Kerkar⁴⁶ Kyung Mo Kim⁴⁷ Jae Sung Ko⁴⁸ Denitza Kofinova⁴⁹ Nolwenn Laborde⁵⁰ Zhongdie Li⁵¹ Patryk Madrid⁵² Rohan Malik⁵³ Saeed Mohammad⁵⁴ Yael Mozer-Glassberg⁵⁵ Gema Muñoz Bartolo³⁹ Gabriella Nebbia⁵⁶ Emanuele Nicastro²⁵ Felipe Ordoñez Ferrero⁵⁷ Anna Orłowska⁷ Arti Pawaria⁵⁸ Tudor Pop⁵⁹ Jesus Quintero Bernabeu⁶⁰ Giusy Ranucci⁶¹ Aathira Ravindranath⁶² Nathalie Rock⁶³ Maria Rogalidou⁶⁴ Ioannis Roilidis⁶⁵ Mathias Ruiz⁶⁶ Thomas D. Sandahl⁶⁷ Srinivas Sankaranarayanan⁶⁸ Mohammad Shagrani¹⁹ Eyal Shteyer⁶⁹ Pooja Reddy Spector⁷⁰ James Squires⁷¹ Ekkehard Sturm⁷² Cristina Targa Ferreira⁷³ Marise Tofoli⁷⁴ Bethany Tucker⁷⁵ Christos Tzivinikos⁷⁶ Wendy van der Woerd⁷⁷ Georg Friedrich Vogel⁷⁸ Heng Wang⁷⁹ Jian-She Wang⁵¹ Sabina Wiecek⁸⁰ Aglaia Zellos⁸¹ Aglaia Zellos⁸¹ Pedro Miranda-Afonso⁸² Bettina E. Hansen⁸² Paola Mian³ Henkjan Verkade³, ¹University of Groningen, University Medical Center Groningen, ²Royal Children's Hospital, ³University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴King's College London, ⁵Texas Children's Hospital, ⁶Hopital Bicetre, ⁷Children's Memorial Health Institute, Warsaw, Poland, ⁸Cliniques St Luc, Brussels, Belgium, ⁹Institute of Liver and Biliary Sciences, ¹⁰Koc University School of Medicine, Istanbul, Turkey, ¹¹Karolinska University Hospital, ¹²CHU Lille, Univ. Lille, Lille, France, ¹³Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates, ¹⁴Tunis Children Hospital, Tunis, Tunisia, ¹⁵Hospital Italiano, CABA, Buenos Aires, Argentina, ¹⁶Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa, ¹⁷Unidade Local de Saúde Coimbra, Coimbra, Portugal, ¹⁸University of Ljubljana, Ljubljana, Slovenia, ¹⁹King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, ²⁰Azienda Ospedaliera Città Della Salute e Della Scienza University Hospital, ²¹University of Padova, ²²National Taiwan University, ²³CHU de Quebec-Université Laval, Quebec City, Canada, ²⁴The Children's Memorial Health Institute, ²⁵Hospital Papa Giovanni XXIII, Bergamo, Italy, ²⁶Hospital da Criança de Brasília, Centro Universitário de Brasília, Brasília, Brazil, ²⁷APHP-Necker Enfants Malades University Hospital, Paris, France, ²⁸Semmelweis University, Budapest, Hungary, ²⁹University of Udine, Udine, Italy, ³⁰Istanbul University Istanbul Medical Faculty, ³¹APHM, Hôpital de la Timone Enfant, France, ³²Children's Mercy Kansas City, ³³Karolinska Institutet, Stockholm, Sweden, ³⁴University Children's Hospital Tübingen, Tübingen, Germany, ³⁵Pediatric Gastroenterology/Hepatology Center Lisbon, Lisbon, Portugal, ³⁶University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³⁷King's College Hospital, ³⁸Birmingham Women’s and Children’s Hospital, Birmingham, United Kingdom, ³⁹Children’s Hospital La Paz, La Paz University Hospital, Madrid, Spain, ⁴⁰Meyer Children’s Hospital, IRCCS, Florence, Italy, ⁴¹Le Kremlin‐Bicêtre, and Inserm U1193, Hepatinov, University of Par, Orsay, France, ⁴²Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada, ⁴³Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark, ⁴⁴Children's Hospital of Philadelphia, ⁴⁵Johns Hopkins University, ⁴⁶Massachusetts General Brigham for Children, ⁴⁷Asan Medical Center Children’s Hospital, Seoul, Korea, Rep. of South, ⁴⁸Seoul National University College of Medicine, Seoul, Rep. of South Korea, ⁴⁹University Multiprofile Hospital for Active Treatment and Emergency Medicine “N.I. Pirogov”, Sofia, ⁵⁰Hôpital des Enfants, CHU de Toulouse, Toulouse, France, ⁵¹Children's Hospital of Fudan University, Shanghai, China, ⁵²Center of Postgraduate Medical Education, Dziekanów Leśny, Poland, ⁵³All India Institute of Medical Sciences, New Delhi, India, ⁵⁴Monroe Carell Jr. Children's Hospital & Vanderbilt University School of Medicine, Nashville, USA, ⁵⁵Schneider Children’s Medical Center of Israel, Petah Tikva, Israel, ⁵⁶Fondazione Irccs Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, ⁵⁷Fundación Cardioinfantil, Bogotá, DC, Colombia, ⁵⁸Amrita Institute of medical Sciences, India, ⁵⁹Emergency Clinical Hospital for Children, Cluj- Napoca, Romania, ⁶⁰Hospital Universiatri Vall d’Hebron, Barcelona, Spain, ⁶¹IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), ⁶²Apollo BGS Hospital, Mysuru, Karnataka, India, ⁶³University Hospital Geneva, ⁶⁴Aghia Sophia Children’s Hospital, National and Kapodistrian University of Athens, Greece, ⁶⁵Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁶⁶Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France, ⁶⁷Aarhus University Hospital, ⁶⁸Kanchi Kamakoti Childs Trust Hospital, Chennai, India, ⁶⁹Shaare Zedek Medical Center, Jerusalem, Israel, ⁷⁰Columbia University Irving Medical Center, New York, New York, USA, ⁷¹Children's Hospital of Pittsburgh, ⁷²Universitats Klinikum Tubingen, ⁷³Hospital da Criança Santo Antônio, ⁷⁴State Hospital for Children and Adolescents, Goiania, Brazil, ⁷⁵King’s College Hospital, London, United Kingdom, ⁷⁶Al Jalila Children’s Specialty Hospital, Dubai, United Arab Emirates, ⁷⁷Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ⁷⁸Medical University of Innsbruck, Innsbruck, Austria, ⁷⁹DDC Clinic for Special Needs Children, Middlefield, Ohio, USA, ⁸⁰Medical University of Silesia, Katowice, Poland, ⁸¹Mitera Children's Hospital, Athens, Greece, ⁸²Erasmus Medical Center, Rotterdam, Netherlands

2655 | LONGITUDINAL PATTERNS OF BILE ACIDS, TOTAL BILIRUBIN, AND PLATELET COUNT PREDICT NATIVE LIVER SURVIVAL IN CHILDREN WITH ALAGILLE SYNDROME

Dominika Wojdyla¹ Bettina Hansen¹ Quinn Rabenau-McDonnell² Morgan Faist² Desiree Vaz³ Jian-She Wang⁴ Zhihong Guan⁴ Irene Jankowska⁵ Piotr Czubkowski⁵ Dorota Gliwicz-Miedzińska⁵ Kathleen Loomes⁶ David Piccoli⁶ Elizabeth Rand⁶ Emmanuel Gonzales⁷ Emmanuel Jacquemin⁷ Jérôme Bouligand⁸ Lorenzo D'Antiga⁹ Emanuele Nicastro¹⁰ Giulia Jannone¹¹ Xavier Stephenne¹¹ Noelle Ebel¹² Jeffrey Feinstein¹³ Andrew Wehrman¹⁴ Bjorn Fischler¹⁵ Henrik Arnell¹⁵ Susan Siew¹⁶ Michael Stormon¹⁶ Kyung Mo Kim¹⁷ Seak Hee Oh¹⁷ Rene Romero¹⁸ Nitika Gupta¹⁸ Florence Lacaille¹⁹ Amin Roberts²⁰ Helen Evans²⁰ Winita Hardikar²¹ M. Kyle Jensen²² Catalina Jaramillo²² Nehal El-Koofy²³ Mohamed Elmonem²⁴ María-Camila Sanchez²⁵ Maria Lorena Cavalieri²⁵ Shikha Sundaram²⁶ Deirdre Kelly²⁷ Jane Hartley²⁸ Henkjan Verkade²⁹ Way Seah Lee³⁰ Henry Lin³¹ Amal Aqul³² Christina Hajinicolaou³³ Chatmanee Lertudomphonwanit³⁴ Ryan Fischer³⁵ Catherine Larson-Nath³⁶ Orith Waisbourd-Zinman³⁷ Cigdem Arikan³⁸ James Squires³⁹ Nathalie Rock⁴⁰ Seema Alam⁴¹ Jesus Quintero Bernabeu⁴² Muriel Girard⁴³ Mureo Kasahara⁴⁴ Elisa De Carvalho⁴⁵ Ruben Quiros-Tejeira⁴⁶ Tasia Kohut⁴⁷ Cristina Targa Ferreira⁴⁸ Giuseppe Indolfi⁴⁹ Pinar Bulut⁵⁰ Pier Luigi Calvo⁵¹ Zerrin Önal⁵² Rima Fawaz⁵³ Aglaia Zellos⁵⁴ Wikrom Karnsakul⁵⁵ Victorien Wolters⁵⁶ Antal Dezsőfi-Gottl⁵⁷ Sabina Wiecek⁵⁸ John Eshun⁵⁹ Giulia Paolella⁶⁰ Raquel Pinto⁶¹ Pamela Valentino⁶² Maria Rogalidou⁶³ María Legarda Tamara⁶⁴ Andreanne Zizzo⁶⁵ Jennifer Garcia⁶⁶ Paulina Ordonez-Naranjo⁶⁷ Marisa Beretta⁶⁸ Simone Kortbeek⁶⁹ Arti Pawaria⁷⁰ Thomas Sandahl⁷¹ Georg Friedrich Vogel⁷² Cristina Campos Gonçalves⁷³ Jernej Brecelj⁷⁴ Miray Karakoyun⁷⁵ Cristina Molera Busoms⁷⁶ Eberhard Lurz⁷⁷ Ermelinda Santos-Silva⁷⁸ Nanda Kerkar⁷⁹ Quais Mujawar⁸⁰ Christos Tzivinikos⁸¹ Carolina Jimenez-Rivera⁸² Luis Bujanda⁸³ Vaidotas Urbonas⁸⁴ Silvia Morise⁸⁵ Richard Thompson⁸⁶ Binita Kamath⁶ Pedro Miranda Afonso¹, ¹Erasmus University Medical Center, Rotterdam, Netherlands, ²Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, ³The Hospital for Sick Children, Toronto, Canada, ⁴The Center for Pediatric Liver Diseases, Children’s Hospital of Fudan University, Shanghai, China, ⁵The Children’s Memorial Health Institute, Warsaw, Poland, ⁶Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, ⁷1)Bicêtre Hospital, 2) Inserm U1193, Université Paris-Saclay, Le Kremlin-Bicêtre, ⁸Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicêtre, France, ⁹1) Ospedale Papa Giovanni XXIII, Bergamo, Italy 2) University of Milano–Bicocca, Milan, Italy, ¹⁰Ospedale Papa Giovanni XXIII, Bergamo, Italy, ¹¹Cliniques Universitaires Saint-Luc, Brussels, Belgium, ¹²Stanford University School of Medicine, Palo Alto, California, ¹³Stanford University School of Medicine, Lucile Packard Children’s Hospital, Palo Alto, California, ¹⁴Boston Children's Hospital, Boston Massachusetts, ¹⁵Karolinska University Hospital, Stockholm, Sweden, ¹⁶The Children’s Hospital at Westmead, Sydney, Australia, ¹⁷Uni. of Ulsan College of Medicine, Asan Medical Center Children’s Hospital, Seoul, Republic of Korea, ¹⁸Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, ¹⁹Necker-Enfants Malades Hospital, University of Paris, Paris, France, ²⁰Starship Child Health, Auckland, New Zealand, ²¹Royal Children's Hospital, Melbourne, Australia, ²²Primary Children’s Hospital, University of Utah, Salt Lake City, Utah, ²³Cairo University, Cairo, Egypt, ²⁴Cairo University, Cairo Egypt, ²⁵Hospital Italiano Buenos Aires, Buenos Aires, Argentina, ²⁶Children’s Hospital of Colorado and University of Colorado School of Medicine, Aurora, Colorado, ²⁷1) Birmingham Women’s and Children’s Hospital 2) University of Birmingham, Birmingham, UK, ²⁸1) Birmingham Women and Children’s Hospital, 2) University of Birmingham, Birmingham, UK, ²⁹University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³⁰University of Malaya, Kuala Lumpur, Malaysia, ³¹Oregon Health and Science University, Portland, Oregon, ³²University of Texas Southwestern Medical Center and Children's Health Dallas, Dallas, Texas, ³³Chris Hani Baragwanath Academic Hospital, Uni. of the Witwatersrand, Johannesburg, South Africa, ³⁴Ramathibodi Hospital Mahidol University, Bangkok, Thailand, ³⁵Children's Mercy Kansas City, Kansas City, Missouri, ³⁶University of Minnesota, Minneapolis, Minnesota, ³⁷Schneider Children's Medical Center, Petah Tikva, Israel, ³⁸Koc University School of Medicine, Istanbul, Turkey, ³⁹Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, ⁴⁰University Hospitals Geneva and University of Geneva, Geneva, Switzerland, ⁴¹Institute of Liver and Biliary Sciences, New Delhi, India, ⁴²Hospital Universiatri Vall d’Hebron, Barcelona, Spain, ⁴³1) Institut Necker-Enfants Malades, 2) Necker Hospital, 75015 Paris, France, ⁴⁴National Center for Child Health and Development, Tokyo, Japan, ⁴⁵Hospital da Crianca de Brasilia, Centro Universitario de Brasilia, Brasilia, Brazil, ⁴⁶Children’s Nebraska and University of Nebraska Medical Center, Omaha, Nebraska, ⁴⁷AdventHealth for Children, Orlando, Florida, ⁴⁸Hospital da Criança Santo Antônio, Porto Alegre, Brazil, ⁴⁹Meyer Children’s University Hospital IRCCS, Florence, Italy, ⁵⁰Phoenix Children’s Hospital, Phoenix, Arizona, ⁵¹Regina Margherita Children’s Hospital, Turin, Italy, ⁵²Istanbul University Faculty of Medicine, Istanbul, Turkey, ⁵³Yale University School of Medicine, New Haven, Connecticut, ⁵⁴1) Ygeia Children's Hospital, 2) University of Athens, Kyriakou Children's Hospital, Athens, Greece, ⁵⁵Johns Hopkins University School of Medicine, Baltimore, Maryland, ⁵⁶University Medical Center Utrecht, Utrecht, Netherlands, ⁵⁷Semmelweis University, Budapest, Hungary, ⁵⁸Medical University of Silesia in Katowice, Katowice, Poland, ⁵⁹Le Bonheur Children’s Hospital, The University of Tennessee Health Science Center, Memphis Tennessee, ⁶⁰Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ⁶¹Hospital Criança Conceição, Grupo Hospitalar Conceição, Porto Alegre, Brazil, ⁶²University of Washington, Seattle Children’s Hospital, Seattle, Washington, ⁶³Aghia Sofia Children’s Hospital, University of Athens, Athens, Greece, ⁶⁴Cruces University Hospital, Bilbao, Spain, ⁶⁵Children’s Hospital, London Health Sciences Centre, Western University, London, Ontario, Canada, ⁶⁶Miami Transplant Institute, University of Miami, Miami, Florida, ⁶⁷University of California San Diego Rady Children's Health, San Diego, California, ⁶⁸Wits Donald Gordon Medical Centre, University of the Witwatersand, Johannesburg, South Africa, ⁶⁹Cumming School of Medicine, University of Calgary, Alberta Children’s Hospital, Alberta, Canada, ⁷⁰Sir H. N. Reliance Foundation Hospital & Research Centre, Mumbai, India, ⁷¹Aarhus University Hospital, Aarhus, Denmark, ⁷²Medical University of Innsbruck, Innsbruck, Austria, ⁷³1) ERN RARE-LIVER 2) Pediatric Gastroenterology/Hepatology Center, Lisbon, Portugal, ⁷⁴University Medical Center Ljubljana, Ljubljana, Slovenia, ⁷⁵Ege University Medical School, Izmir, Turkey, ⁷⁶Hospital Sant Joan de Deu, Esplugues de Llobregat, Spain, ⁷⁷Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany, ⁷⁸1) Centro Hospitalar Universitario de Santo Antonio 2) Universidade do Porto, Porto, Portugal, ⁷⁹Mass General Brigham for Children, Harvard Medical School, Boston, Massachusetts, ⁸⁰University of Manitoba, Winnipeg, Canada, ⁸¹Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates, ⁸²Children’s Hospital of Eastern Ontario, Ottowa Canada, ⁸³Donostia University Hospital, Universidad del Pais Vasco, San Sebastian, Spain, ⁸⁴Vilnius University Medical Faculty Clinic of Children's Diseases, Vilnius, Lithuania, ⁸⁵José C. Paz, Buenos Aires, Argentina,, ⁸⁶King’s College London, London, United Kingdom

2658 | MITOCHONDRIAL HEPATOPATHY: GENETIC ETIOLOGY AND CLINICAL SPECTRUM FROM OVER 100 CHILDREN

James Squires¹ Alexander Miethke² Kieran Hawthorne³ Johan Van Hove⁴ Simon Horslen⁵ Rohit Kohli⁶ Akihiro Asai² Mark Lovell⁷ Estella Alonso⁸ Saul Karpen⁹ Kathleen Loomes¹⁰ Steve Guthery¹¹ Jean Molleston¹² Pamela Valentino¹³ Benjamin Shneider¹⁴ Kasper Wang⁶ Philip Rosenthal¹⁵ John Magee¹⁶ Ronald Sokol¹⁷, ¹Children's Hospital of Pittsburgh, ²Cincinnati Children's Hospital Medical Center, ³Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States, ⁴Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado, ⁵UPMC Children's Hospital of Pittsburgh, ⁶Children's Hospital Los Angeles, ⁷Department of Pathology, Children's Hospital Colorado, ⁸Ann and Robert H. Lurie Children's Hospital of Chicago, ⁹VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, ¹⁰The Children's Hospital of Philadelphia, ¹¹Primary Children's Hospital, ¹²Riley Hospital for Children, Indiana University School of Medicine, ¹³University of Washington, ¹⁴Texas Children's Hospital, ¹⁵University of California, San Francisco, ¹⁶University of Michigan Hospitals and Health Centers, ¹⁷University of Colorado School of Medicine

2664 | GROWTH IN 433 CHILDREN WITH PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS (PFIC): THE INFLUENCE OF PFIC SUBTYPE AND SEX

Alise de Groot¹ Elizabeth Bannister² Mark Nomden¹ Richard Thompson³ Benjamin Shneider⁴ Emmanuel Gonzales⁵ Irena Jankowska⁶ Etienne Sokal⁷ Seema Alam⁸ Cigdem Arikan⁹ Henrik Arnell¹⁰ Madeleine Aumar¹¹ Amer Azaz¹² Emna Barkaoui¹³ María Belén Pallitto¹⁴ Marisa Beretta¹⁵ Teresa Botelho¹⁶ Jernej Brecelj¹⁷ Dieter Broering¹⁸ Pier Luigi Calvo¹⁹ Mara Cananzi²⁰ Huey-Ling Chen²¹ Guillermo Costaguta²² Piotr Czubkowski²³ Lorenzo D'Antiga²⁴ Elisa Carvalho²⁵ Dominique Debray²⁶ Antal Dezs?fi²⁷ Angelo Di Giorgio²⁸ Ozlem Durmaz²⁹ Alexandre Fabre³⁰ Ryan Fischer³¹ Björn Fischler³² Tanja Fritz³³ Cristina Gonçalves³⁴ Enke Grabhorn³⁵ Tassos Grammatikopoulos³⁶ Girish Gupte³⁷ Winita Hardikar² Loreto Hierro³⁸ Giuseppe Indolfi³⁹ Emmanuel Jacquemin⁴⁰ Giulia Jannone⁷ Carolina Jimenez-Rivera⁴¹ Marianne Hørby Jørgensen⁴² Binita Kamath⁴³ Wikrom Karnsakul⁴⁴ Nanda Kerkar⁴⁵ Kyung Mo Kim⁴⁶ Jae Sung Ko⁴⁷ Denitza Kofinova⁴⁸ Nolwenn Laborde⁴⁹ Zhongdie Li⁵⁰ Patryk Lipi?ski⁵¹ Rohan Malik⁵² Saeed Mohammad⁵³ Yael Mozer-Glassberg⁵⁴ Gema Muñoz Bartolo³⁸ Gabriella Nebbia⁵⁵ Emanuele Nicastro²⁴ Felipe Ordoñez Ferrero⁵⁶ Anna Orłowska⁶ Arti Pawaria⁵⁷ Tudor Pop⁵⁸ Jesus Quintero Bernabeu⁵⁹ Giusy Ranucci⁶⁰ Aathira Ravindranath⁶¹ Nathalie Rock⁶² Maria Rogalidou⁶³ Ioannis Roilidis⁶⁴ Mathias Ruiz⁶⁵ Thomas Sandahl⁶⁶ Srinivas Sankaranarayanan⁶⁷ Mohammad Shagrani⁶⁸ Eyal Shteyer⁶⁹ Pooja Reddy Spector⁷⁰ James Squires⁷¹ Ekkehard Sturm⁷² Cristina Targa Ferreira⁷³ Marise Tofoli⁷⁴ Bethany Tucker⁷⁵ Christos Tzivinikos⁷⁶ Wendy van der Woerd⁷⁷ Georg Friedrich Vogel⁷⁸ Heng Wang⁷⁹ Jian-She Wang⁵⁰ Sabina Wiecek⁸⁰ Aglaia Zellos⁸¹ Andreanne Zizzo⁸² Pedro Miranda-Afonso⁸³ Bettina Hansen⁸³ Paola Mian¹ Henkjan Verkade¹, ¹University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Royal Children's Hospital, ³King's College London, ⁴Texas Children's Hospital, ⁵Hopital Bicetre, ⁶Children's Memorial Health Institute, Warsaw, Poland, ⁷Cliniques St Luc, Brussels, Belgium, ⁸Institute of Liver and Biliary Sciences, ⁹Koc University School of Medicine, Istanbul, Turkey, ¹⁰Karolinska University Hospital, ¹¹CHU Lille, Univ. Lille, Lille, France, ¹²Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates, ¹³Tunis Children Hospital, Tunis, Tunisia, ¹⁴Hospital Italiano, CABA, Buenos Aires, Argentina, ¹⁵Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa, ¹⁶Unidade Local de Saúde Coimbra, Coimbra, Portugal, ¹⁷University of Ljubljana, Ljubljana, Slovenia, ¹⁸King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Alfaisal, ¹⁹Azienda Ospedaliera Città Della Salute e Della Scienza University Hospital, ²⁰University of Padova, ²¹National Taiwan University, ²²CHU de Quebec-Université Laval, Quebec City, Canada, ²³The Children's Memorial Health Institute, ²⁴Hospital Papa Giovanni XXIII, Bergamo, Italy, ²⁵Hospital da Criança de Brasília, Centro Universitário de Brasília, Brasília, Brazil, ²⁶APHP-Necker Enfants Malades University Hospital, Paris, France, ²⁷Semmelweis University, Budapest, Hungary, ²⁸University of Udine, Udine, Italy, ²⁹Istanbul University Istanbul Medical Faculty, ³⁰APHM, Hôpital de la Timone Enfant, France, ³¹Children's Mercy Kansas City, ³²Karolinska Institutet, Stockholm, Sweden, ³³University Children's Hospital Tübingen, Tübingen, Germany, ³⁴Pediatric Gastroenterology/Hepatology Center Lisbon, Lisbon, Portugal, ³⁵University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³⁶King's College Hospital, ³⁷Birmingham Women’s and Children’s Hospital, Birmingham, United Kingdom, ³⁸Children’s Hospital La Paz, La Paz University Hospital, Madrid, Spain, ³⁹Meyer Children’s Hospital, IRCCS, Florence, Italy, ⁴⁰Le Kremlin‐Bicêtre, and Inserm U1193, Hepatinov, University of Par, Orsay, France, ⁴¹Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada, ⁴²Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark, ⁴³Children's Hospital of Philadelphia, ⁴⁴Johns Hopkins University, ⁴⁵Massachusetts General Brigham for Children, ⁴⁶Asan Medical Center Children’s Hospital, Seoul, Korea, Rep. of South, ⁴⁷Seoul National University College of Medicine, Seoul, Rep. of South Korea, ⁴⁸University Multiprofile Hospital for Active Treatment and Emergency Medicine “N.I. Pirogov”, Sofia, ⁴⁹Hôpital des Enfants, CHU de Toulouse, Toulouse, France, ⁵⁰Children's Hospital of Fudan University, Shanghai, China, ⁵¹Center of Postgraduate Medical Education, Dziekanów Leśny, Poland, ⁵²All India Institute of Medical Sciences, New Delhi, India, ⁵³Monroe Carell Jr. Children's Hospital & Vanderbilt University School of Medicine, Nashville, USA, ⁵⁴Schneider Children’s Medical Center of Israel, Petah Tikva, Israel, ⁵⁵Fondazione Irccs Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, ⁵⁶Fundación Cardioinfantil, Bogotá, DC, Colombia, ⁵⁷Amrita Institute of medical Sciences, India, ⁵⁸Emergency Clinical Hospital for Children, Cluj-Napoca, Romania, ⁵⁹Hospital Universiatri Vall d’Hebron, Barcelona, Spain, ⁶⁰IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), ⁶¹Apollo BGS Hospital, Mysuru, Karnataka, India, ⁶²University Hospital Geneva, ⁶³Aghia Sophia Children’s Hospital, National and Kapodistrian University of Athens, Greece, ⁶⁴Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁶⁵Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France, ⁶⁶Aarhus University Hospital, ⁶⁷Kanchi Kamakoti Childs Trust Hospital, Chennai, India, ⁶⁸King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, ⁶⁹Shaare Zedek Medical Center, Jerusalem, Israel, ⁷⁰Columbia University Irving Medical Center, New York, New York, USA, ⁷¹Children's Hospital of Pittsburgh, ⁷²Universitats Klinikum Tubingen, ⁷³Hospital da Criança Santo Antônio, ⁷⁴State Hospital for Children and Adolescents, Goiania, Brazil, ⁷⁵King’s College Hospital, London, United Kingdom, ⁷⁶Al Jalila Children’s Specialty Hospital, Dubai, United Arab Emirates, ⁷⁷Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ⁷⁸Medical University of Innsbruck, Innsbruck, Austria, ⁷⁹DDC Clinic for Special Needs Children, Middlefield, Ohio, USA, ⁸⁰Medical University of Silesia, Katowice, Poland, ⁸¹Mitera Children's Hospital, Athens, Greece, ⁸²London Children's Hospital, Western University, London, Ontario, Canada, ⁸³Erasmus Medical Center, Rotterdam, Netherlands

2666 | SURGICAL BILIARY DIVERSION EFFECTIVELY TREATS CHOLESTATIC PRURITUS IN FIC1 DEFICIENCY PATIENTS NOT RESPONDING TO IBAT INHIBITION

Willem Lexmond¹ Amala Alenchery² Alise de Groot¹ Winita Hardikar³ Anna Orłowska⁴ Piotr Czubkowski⁴ Pamela Valentino⁵ James Squires² Henkjan Verkade¹, ¹University Medical Center Groningen, ²Children's Hospital of Pittsburgh, ³Royal Children's Hospital, ⁴The Children's Memorial Health Institute, ⁵Seattle Children's Research Institute

2667 | LIGHT AND ELECTRON MICROSCOPY DEMONSTRATE LIMITED DIAGNOSTIC SPECIFICITY IN PEDIATRIC MITOCHONDRIAL HEPATOPATHIES

Mark Lovell¹ Eric Wartchow² M.Cristina Pacheco³ Colleen Kincaid⁴ Kieran Hawthorne⁴ Ronald Sokol⁵ Estella Alonso⁶ Steve Guthery⁷ Simon Horslen⁸ Saul Karpen⁹ Rohit Kohli¹⁰ Kathleen Loomes¹¹ John Magee¹² Alexander Miethke¹³ Jean Molleston¹⁴ Phillip Rosenthal¹⁵ Benjamin Shneider¹⁶ Pamela Valentino¹⁷ Kasper Wang¹⁸ Grace Kim¹⁹ Childhood Liver Disease Research Network (ChiLDRen)²⁰, ¹Children's Hospital Colorado and University of Colorado Anschutz School of Medicine, Aurora, CO, ²Children's Hospital Colorado, Aurora, CO, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Arbor Research Collaborative for Health, Ann Arbor, MI, ⁵Children's Hospital Colorado and University of Colorado Anschutz School of Medicine, ⁶Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern Univ Feinberg SOM, Chicago, IL, ⁷Intermountain Primary Children's Hospital, University of Utah, Salt Lake City, UT, ⁸UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁹VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Richmond, VA, ¹⁰Children's Hospital Los Angeles, Univ Southern California, Keck School of Medicine, Los Angeles, CA, ¹¹The Children's Hospital of Philadelphia, Perelman School of Medicine @ Univ of Penn,Philadelphia, PA, ¹²University of Michigan Hospitals and Health Centers, Univ of Michigan Medical School, Ann Arbor, MI, ¹³Cincinnati Children's Hospital Medical Center, Univ of Cincinnati Medical School, Cincinnati, OH, ¹⁴Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, ¹⁵UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, ¹⁶Texas Children's Hospital, Baylor College of Medicine, Houston, TX, ¹⁷Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, ¹⁸The Hospital for Sick Children, University of Toronto, Toronto, ON, CANADA, ¹⁹University of California San Francisco, San Francisco, CA, ²⁰The Childhood Liver Disease Research Network (ChiLDReN)

2689 | MULTI-CENTER COMPARISON OF "ADJUSTED MEAN ALT" IN THE 5TH YEAR AFTER PEDIATRIC LIVER TRANSPLANTATION (LT)

Elizabeth Raby¹ Sandy Feng¹ Emily Perito¹ SPLIT Society of Pediatric Liver Transplantation² Elizabeth Rand³ Nitika Gupta⁴ James Squires⁵, ¹UCSF, ²Society of Pediatric Liver Transplantation, ³CHOP, ⁴Emory University School of Medicine, ⁵Children's Hospital of Pittsburgh

2693| POTENTIAL BIOMARKERS IN ACTIVATED T-CELL PEDIATRIC ACUTE LIVER FAILURE FOR DIAGNOSIS AND RECOVERY: TNFSF11, ITGA11 AND LTA4H

Tamir Diamond¹ Catherine Chapin² Alyssa Baccarella¹ Caroline Diorio¹ Portia Kreiger¹ Sarah Henrickson¹ Ezuka Ogbolu¹ Niansheng Chu¹ Anna Banc-Husu³ Daniel Leung⁴ Amrita Narang⁵ Beth Carter⁶ Scott Elisofon⁷ Ryan Fischer⁸ Amber Hildreth⁹ Mike Leonis¹⁰ Steven Lobritto¹¹ Saeed Mohammad¹² Anna Peters¹³ Norberto Rodriguez-Baez¹⁴ Rene Romero¹⁵ David Rudnick¹⁶ James Squires¹⁷ Shikha Sundaram¹⁸ Kyla Tolliver¹⁹ Pamela Valentino²⁰ Zemin Su²¹ Valerie Durkalski-Mauldin²¹ Katie Neighbors²² Simon Horslen²³ Kathleen Loomes¹ Estella Alonso² Edward Behrens¹, ¹The Children's Hospital of Philadelphia, ²Ann and Robert H. Lurie Children's Hospital of Chicago, ³Baylor College of Medicine, Texas Children's Hospital, ⁴Texas Children's Hospital, ⁵Stanford, ⁶Children's Hospital Los Angeles, ⁷Boston Childrens Hospital, ⁸Children's Mercy Kansas City, ⁹University of California San Diego, ¹⁰Cleveland Clinic Children's Outpatient Center (R3), ¹¹NY Presbyterian Hospital - Columbia University, ¹²Monroe Carell Jr. Children’s Hospital at Vanderbilt, ¹³Cincinnati Children's Hospital Medical Center, ¹⁴University of Texas Southwestern Medical Center, ¹⁵Emory University School of Medicine, ¹⁶Washington University Medical Center, ¹⁷Children's Hospital of Pittsburgh, ¹⁸Children's Hospital Colorado, ¹⁹Indiana University, ²⁰University of Washington, ²¹Medical University of South Carolina, ²²Ann & Robert H. Lurie Children's Hospital of Chicago, ²³UPMC Children's Hospital of Pittsburgh

2694 | THE CHILDHOOD LIVER DISEASE RESEARCH NETWORK PROSPECTIVE CHARACTERIZATION OF PEDIATRIC PRIMARY SCLEROSING CHOLANGITIS

Cara Mack¹ Alexander Miethke² Kieran Hawthorne³ Lisa Henn³ Simon Horslen⁴ Estella Alonso⁵ Nitika Gupta⁶ Shikha Sundaram⁷ Rohit Kohli⁸ Molly Bozic⁹ Mark Deneau¹⁰ Kathleen Loomes¹¹ Pamela Valentino¹² Mary Elizabeth Tessier¹³ Benjamin Shneider¹⁴ John Magee¹⁵ Saul Karpen¹⁶ Philip Rosenthal¹⁷ Kasper Wang¹⁸ Amanda Ricciuto¹⁹ Ronald Sokol²⁰ Binita Kamath²¹ ChiLDReN Childhood Liver Disease Research Network²², ¹Medical College of Wisconsin, ²Cincinnati Children's Hospital Medical Center, ³Arbor Research Collaborative for Health, ⁴UPMC Children's Hospital of Pittsburgh, ⁵Ann and Robert H. Lurie Children's Hospital of Chicago, ⁶Emory University School of Medicine, ⁷Children's Hospital Colorado, ⁸Children's Hospital Los Angeles, ⁹Indiana University School of Medicine, ¹⁰University of Utah, ¹¹The Children's Hospital of Philadelphia, ¹²University of Washington, ¹³Texas Children's Liver Center - Baylor College of Medicine, ¹⁴Texas Children's Hospital, ¹⁵University of Michigan Hospitals and Health Centers, ¹⁶VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, ¹⁷University of California, San Francisco, ¹⁸Hospital for Sick Children, University of Toronto, ¹⁹Hospital for Sick Children, ²⁰University of Colorado School of Medicine, ²¹Children's Hospital of Philadelphia, ²²NIH NIDDK

3033 | RENAL OUTCOMES AFTER LIVER TRANSPLANTATION FOR ALCOHOL-ASSOCIATED HEPATITIS

Claire Durkin¹ Shari Rogal¹ Ravy Vajravelu¹, ¹University of Pittsburgh

3038 | HEALTHCARE-ASSOCIATED INFECTIONS ARE COMMON AND ASSOCIATED WITH EARLY MORTALITY IN SEVERE ALCOHOL-ASSOCIATED HEPATITIS: A CONTEMPORARY MULTICENTER STUDY

Douglas Simonetto¹ Wanzhu Tu² Srinivasan Dasarathy³ Ashwani Singal⁴ Amon Asgharpour⁵ Juan Pablo Arab⁵ Qing Tang² Nicole Welch³ Vatsalya Vatsalya⁴ Jacqueline O'Leary⁶ Wanyu Zhang⁴ Maiying Kong⁴ Patrick Kamath⁷ Ramon Bataller⁸ Gyongyi Szabo⁹ Craig McClain⁴ Vijay Shah¹ Naga Chalasani¹⁰ Mack Mitchell¹¹ Arun Sanyal⁵ Samer Gawrieh², ¹Mayo Clinic Rochester, ²Indiana University, ³Cleveland Clinic, ⁴University of Louisville, ⁵Virginia Commonwealth University, ⁶University of Texas Southwestern, ⁷Mayo Clinic, ⁸University of Pittsburgh, ⁹Beth Israel Deaconess Medical Center, ¹⁰Indiana University Medical Center, ¹¹University of Texas Southwestern Medical Center

3047 | HEAVY DRINKING PATTERNS AND MULTISYSTEM ALCOHOL-ASSOCIATED DISEASE: A GLOBAL ECOLOGICAL STUDY

Denisse Rubio Cruz¹ Ximena Parraga² Kriti Soni² Tulio Correa³ Hyundam (Dami) Gu² Rylyn Reyes² Adelina Horhat⁴ Joshua Chen² S. Fisher Rhoads² Vinay Jahagirdar² Kavin Parmar² Krishan Patel² Stephen Hoang² Luis Díaz⁵ Juan Pablo Arab², ¹Lahey Hospital; Virginia Commonwealth University, ²Virginia Commonwealth University, ³University of Pittsburgh, ⁴Department of Hepatology, Henri Mondor University Hospital, ⁵Pontificia Universidad Católica de Chile

3085 | MEAN ARTERIAL PRESSURE IS INDEPENDENTLY ASSOCIATIED WITH 90-DAY MORTALITY IN

Samer Gawrieh¹ Wanzhu Tu² Qing Tang² Merixtell Ventura Cots³ Srinivasan Dasarathy⁴ Mack Mitchell⁵ Vijay Shah⁶ Arun Sanyal⁷ Craig McClain⁸ Gyongyi Szabo⁹ Juan Pablo Arab⁷ Ashwani Singal⁸ Suthat Liangpunsakul² Ramon Bataller¹⁰ Naga Chalasani¹¹ AlcHepNet Investigators¹², ¹Indiana University School of Medicine, ²Indiana University, ³Barcelona Clinic, ⁴Cleveland Clinic, ⁵University of Texas Southwestern Medical Center, ⁶Mayo Clinic Rochester, ⁷Virginia Commonwealth University, ⁸University of Louisville, ⁹Beth Israel Deaconess Medical Center, ¹⁰University of Pittsburgh, ¹¹Indiana University Medical Center, ¹²AlcHepNet

3088 | DYNAMIC LIVER STIFFNESS MEASUREMENT CHANGES PREDICT LIVER-RELATED EVENTS ACROSS FIBROSIS STRATA IN STEATOTIC LIVER DISEASE

Hyundam (Dami) Gu¹ Luis Díaz² Natalia Baeza² Francisco Idalsoaga³ Cristiane Villela-Nogueira⁴ Natalia Balassiano Wajsbrot⁴ Ana Carolina Cardoso⁴ Nathalie Leite⁴ Gil Salles⁴ Claudia Cardoso⁴ Anand Kulkarni⁵ Ramagundam Ramyasri⁶ William Alazawi⁷ Wenhao Li⁷ Laura Temperley⁷ Maria Poca⁸ Berta Cuyas⁸ Terry Cheuk-Fung Yip⁹ Vincent Wai-Sun Wong⁹ Grace Wong⁹ Jimmy Che-To Lai⁹ Jose Velarde Ruiz Velasco¹⁰ Juan Roblero¹¹ Daniela Simian¹² Pamela Gil Galleguillos¹² Mohamed El-Kassas¹³ Claudia Couto¹⁴ Guilherme Grossi Cancado¹⁵ Sebastian Marciano¹⁶ Jorge Martínez¹⁶ Maria Jose Acosta¹⁶ Adrián Gadano¹⁶ Ismael Yepes¹⁷ Luis Molina Barrios¹⁷ Argemiro Lara¹⁷ MaríaFernanda SaavedraChacón¹⁸ Eira Cerda Reyes¹⁹ Stefanny Cornejo Henández¹⁹ Graciela Castro-Narro²⁰ Sheel Patel²¹ Ashwani Singal²¹ Katrina Pekarska²² Richard Parker²² Mohamad Ali Ibrahim²³ Prasun Jalal²³ Mazen Noureddin²⁴ Naim Alkhouri²⁵ Winston Dunn²⁶ Patrick Kamath²⁷ Arun Sanyal¹ Richard Sterling¹ Maraco Arrese² Ramon Bataller²⁸ Juan Pablo Arab¹, ¹Virginia Commonwealth University, ²Pontificia Universidad Católica de Chile, ³Pontificia Universidad Católica de Chile; Western University, ⁴Universidade Federal do Rio de Janeiro, ⁵Asian Institute of Gastroenterology, ⁶AIG Hospitals, ⁷Blizard Institute, Queen Mary University of London, ⁸Institut de Recerca Hospital de Sant Pau-IIB Sant Pau, Universitat Autònoma de Barcelona, ⁹The Chinese University of Hong Kong, ¹⁰Hospital Civil de Guadalajara, ¹¹University of Chile, ¹²Universidad de Chile, ¹³Capital University, ¹⁴Federal University of Minas Gerais, ¹⁵Universidade Federal de Minas Gerais, ¹⁶Hospital Italiano de Buenos Aires, ¹⁷Universidad de Cartagena, ¹⁸Clínica CES, ¹⁹Central Military Hospital, ²⁰Hospital Médica Sur, Ciudad de México. Instituto Nacional de Ciencias Médicas y Nutrición, ²¹University of Louisville, ²²Leeds Teaching Hospitals NHS Trust, ²³Baylor College of Medicine, ²⁴Houston Methodist Hospital, ²⁵Summit Clinical Research, ²⁶University of Kansas Medical Center, ²⁷Mayo Clinic, ²⁸University of Pittsburgh

3093 | PROGRESSION TO SEVERE ALCOHOL-ASSOCIATED HEPATITIS (AH) IS COMMON IN PATIENTS WITH MODERATE AH AND IS ASSOCIATED WITH A HIGHER RISK OF MAJOR ADVERSE LIVER OUTCOMES

Ashwani Singal¹ Wanzhu Tu² Yunpeng Yu² Vatsalya Vatsalya¹ Nicole Welch³ Douglas Simonetto⁴ Juan Pablo Arab⁵ Jacqueline O'Leary⁶ Srinivasan Dasarathy³ Suthat Liangpunsakul² Mack Mitchell⁷ Arun Sanyal⁵ Naga Chalasani⁸ Gyongyi Szabo⁹ Ramon Bataller¹⁰ Craig McClain¹ Samer Gawrieh⁸, ¹University of Louisville, ²Indiana University, ³Cleveland Clinic, ⁴Mayo Clinic Rochester, ⁵Virginia Commonwealth University, ⁶UTSW, ⁷University of Texas Southwestern Medical Center, ⁸Indiana University Medical Center, ⁹Beth Israel Deaconess Medical Center, ¹⁰University of Pittsburgh

3096 | MATRIX-BOUND NANOVESICLES AS MODULATORS IN ALCOHOL-RELATED LIVER DISEASE

Yekaterina Krutsenko¹ Bashar Al Matour¹ Jiang Li¹ Jia-Jun Liu¹ Lorien Walker¹ Michael Merchant² Silvia Liu¹ George Hussey¹ Melanie Scott¹ Gavin Arteel¹, ¹University of Pittsburgh, ²University of Louisville

3177 | GLOBAL PATTERNS OF ALCOHOL-RELATED CARDIOMYOPATHY AND ALCOHOL CONSUMPTION: AN ECOLOGICAL STUDY FROM 2017–2023

Denisse Rubio Cruz¹ Ximena Parraga¹ Kriti Soni¹ Tulio Correa² Rylyn Reyes¹ Hyundam (Dami) Gu¹ Joshua Chen¹ Adelina Horhat¹ Vinay Jahagirdar¹ Kavin Parmar¹ Krishan Patel¹ S. Fisher Rhoads¹ Stephen Hoang¹ Luis Antonio Diaz¹ Juan Pablo Arab¹, ¹Virginia Commonwealth University, ²University of Pittsburgh

3284 | INTEGRATING SOCIAL DETERMINANTS OF HEALTH INTO MACHINE LEARNING MODELS TO PREDICT HEPATITIS C TREATMENT INITIATION AMONG MEDICAID BENEFICIARIES

Suk-Chan Jang¹ Wei-Hsuan Lo-Ciganic² Chanakan Jenjai¹ Pilar Hernandez-Con¹ Khoa Nguyen¹ Robert Cook¹ Christine Gage¹ David Nelson¹ Haesuk Park¹, ¹University of Florida, ²University of Pittsburgh

3301 | PREGNANCY OUTCOMES FOLLOWING GLECAPREVIR/PIBRENTASVIR EXPOSURE IN PREGNANT WOMEN WITH HEPATITIS C: A PHARMACOVIGILANCE ANALYSIS

Tatyana Kushner¹ Barbra Cave² John Marcinak² Catherine Chappell³ Laura Marks⁴ Madeline McCrary⁴ Ahizechuwu Eke⁵ Alexandru Iacob² Josephine Kwong² Rinal Patel² Ravi Jhaveri⁶, ¹Weill Cornell Medicine, ²AbbVie Inc, ³University of Pittsburgh Medical Center, ⁴Washington University School of Medicine, St. Louis, ⁵Johns Hopkins University, ⁶Northwestern University Feinberg School of Medicine

3336 | ENVIRONMENTAL CO-EXPOSURE TO PFAS AND HEAVY METALS CREATES A CLINICALLY RELEVANT PRO-TUMORIGENIC TRANSCRIPTOMIC SIGNATURE IN A NON-TUMOR MASLD MOUSE MODEL

Haley Arbore¹ Hamda Siddiqui¹ Shannon Heinig¹ Pooja Muddasani¹ Charis-Marie Vanderpuye¹ Jiang Li¹ Natalie Price¹ Zachary Zimmerman¹ Shuai Yuan¹ Sudrishti Chaudhary¹ Noriko Kitano¹ Tyler Yasaka¹ Jia-Jun Liu¹ Silvia Liu¹ Gavin Arteel¹ Junyan Tao¹ Satdarshan (Paul) Monga¹ Alison Sanders¹ Juliane Beier¹, ¹University of Pittsburgh

3580 | PROSPECTIVE VALIDATION OF RISK OF LIVER FIBROSIS PROGRESSION ASSOCIATED WITH ADDED SUGAR INTAKE IN PATIENTS WITH MASLD USING OBJECTIVE BLOOD BIOMARKERS AND MICROPHYSIOLOGICAL SYSTEM

Jaideep Behari¹ Olivia Popovich¹ Renwei Wang¹ Mark Miedel¹ Mahboubeh Varmazyad¹ Dillon Gavlock¹ D. Lansing Taylor¹ Jian-Min Yuan¹, ¹University of Pittsburgh

4187 | COMPARISONS OF INTEGRATED HBV DNA (IDNA) PROFILES BETWEEN MATCHED LIVER AND PLASMA SAMPLES FROM PATIENTS WITH HBEAG(+) AND HBEAG(-) CHRONIC HEPATITIS B

Daryl Lau¹ Hsin-Ni Liu² Zhili Wang³ Zach Heimer³ Selena Lin³ Fwu-Shan Shieh³ Haitao Guo⁴ Ying-Hsiu Su⁵, ¹Beth Israel Deaconess Medical Center, Harvard Medical School, ²The Baruch S. Blumberg Institute, ³JBS Science Inc. Lansdale, PA, ⁴University of Pittsburgh, ⁵Baruch S. Blumberg Institute

4249 | TRANSCRIPTOMIC SHANNON DIVERSITY STRATIFIES PROGNOSIS AND MARKS AN ONCOFETAL SUBTYPE IN GRADE 1 HEPATOCELLULAR CARCINOMA

Haley Arbore¹ Jia-Jun Liu¹ Silvia Liu¹ Panayiotis Benos² Juliane Beier¹ Gavin Arteel¹, ¹University of Pittsburgh, ²University of Florida

4369 | DUAL INHIBITION OF INOS AND COX2 REMODELS MYELOID PROGRAMS TO IMPROVE RESPONSE TO PD-L1 BLOCKADE IN HEPATOCELLULAR CARCINOMA

Qianru Wu¹ Yuzhen Li¹ Timothy Billiar¹, ¹University of Pittsburgh

4387 | TRANSCRIPTOMIC PROFILING REVEALS INTRINSIC MULTI-MECHANISM PD-1 RESISTANCE IN VINYL CHLORIDE-ASSOCIATED HCC

Haley Arbore¹ Pooja Muddasani¹ Olivia Bannister¹ Jiang Li¹ Tyler Yasaka¹ Silvia Liu¹ Gavin Arteel¹ Junyan Tao¹ Satdarshan (Paul) Monga¹ Juliane Beier¹, ¹University of Pittsburgh

4421 | UNOS-BASED TRENDS IN NMP UTILIZATION AND OUTCOMES FOR DCD AND DBD LIVER TRANSPLANTATION BETWEEN 2021-2025

Ozge Ozgur¹ Shanmukh Lingamsetty² Umnia Shnawa² Malak Elsawy² Ahmet Gurakar³ Behnam Saberi⁴, ¹University of Pittsburgh Medical Center, ²BIDMC, Harvard Medical School, ³Johns Hopkins University, ⁴BIDMC Harvard Medical School

4543 | INCIDENCE OF CHYLOUS COMPLICATIONS AFTER PEDIATRIC LIVER TRANSPLANTATION: A SINGLE-CENTER RETROSPECTIVE ANALYSIS

Richa Gupta¹ Rachel Smith¹, ¹UPMC Children's Hospital of Pittsburgh

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