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The 30th annual North American Cystic Fibrosis Conference was held October 27-29 in Orlando. The event brought scientists, clinicians, and other healthcare professionals from around the world to share the latest ideas and advances in cystic fibrosis research, drug development, and patient care, and included posters and presentations from field-leading experts.
Several Children’s Hospital of Pittsburgh of UPMC faculty and staff presented at the conference on a number of topics including:
Poster: Identification of Novel Inhibitors of Ubiquitination That Improve Rescue of F508DELCFTR by VX-809
Goeckeler-Fried, Jennifer; Estabrooks, Samuel K; Chiang, Annette; Chung, Wook Joon; Ye, Zhaofeng; Denny, Rajiah Aldrin; Weissman, Allan M; Camacho, Carlos J; Sorscher, Eric J; Brodsky, Jeffrey L
Poster: Recognition of CFTR By BCL2 Associated Athnaogene 3 (BAG3): A Pathway meditating Autophagic CFTR Degradation
Mishra, Sanjay K ; Frizzell, Raymond A.
Poster: Ubiquitin-Specific Proteases 11(USP11)and 28(USP28)Regulate F508DELCFTRStability Via SUMOConjugation
Gong, Xiaoyan; DaPaula ,AnaCarina; Ahner, Annette; Frizzell, Raymond A
Poster/Workshop Presentation: Predicted Phosphorylation Site in SLC26A9 Modulates CFTR-Dependent Activity
Wang, Xiaohui; Larsen, Mads B; Frizzell, Raymond A.; Bertrand, Carol A.
Poster: Pseudomonas aeruginosa Benefits From Respiratory Viral Infection in Cystic Fibrosis
Jeffrey Melvin
Poster: Viral-Bacterial Interactions in the Paranasal Sinuses in Cystic Fibrosis
Jeffrey Melvin
Abstract: Dynamics of Staphylococcus aureus growth on airway epithelial cells
Megan R Kiedrowski
Presenting: Thursday, Oct. 27 – W06: INF/MIC: Pathogenesis of Airway Infection (speaking 10:20-10:30a)
Poster Session I (11:15a-1:45p), Friday, Oct. 28 – JIB: Junior investigators best abstract session: Basic Science (12:15-1:35p)
Poster: Dysregulation of Nutritional Immunity during Respiratory Viral Infection Promotes Pseudomonas aeruginosa Biofilm Growth
Matthew Hendricks
Poster: SIRT1 Mediates Resveratrol Inhibition of CFTR In Primary Bronchial Epithelium
Agnieszka Swiatecka-Urban, MD, FASN
Poster: TGF-β1 Upregulates Microrna- 145 To Block ∆F508-CFTR Rescue
Agnieszka Swiatecka-Urban, MD, FASN
Poster: Anti-biofilm activity and in vivo efficacy of an engineered peptide antibiotic”
Berthony Deslouches
Workshop III: CLIN: *Emerging Issues in CF Lung Transplantation
A. Faro, J. Pilewski
Poster: Infection and depressed mucociliary clearance in pediatric and adult CF patients
Corcoran TE, Locke LW, Myerburg MM, Weiner DJ, Pilewski JM
Poster: Nitrogen Back Diffusion During Multiple Breath Washout With 100% Oxygen
Weiner DJ, Pederson K, Nielson JG.
Poster: Lung Function Perception in Cystic Fibrosis
Forno E, Weiner DJ