UPMC Physicians and Researchers Presenting at American Association for the Study of Liver Diseases (AASLD) 2025 Meeting

November 5, 2025

Physicians and researchers from UPMC, UPMC Children’s Hospital of Pittsburgh, the University of Pittsburgh, and the Pittsburgh Liver Research Center will participate in the AASLD 2025 Meeting, taking place Nov. 7 to 11, in Washington, D.C.

Presentations and sessions featuring UPMC and Pitt researchers include:

Basic Science Symposium: Endothelial Cells Occupy Center Stage in Liver Diseases, Part 2—Endothelial Cell

• Presenter and Moderator: Satdarshan (Paul) Monga, MD

American Association for the Study of Liver Diseases and the International Liver Transplantation Society Course (AASLD/ILTS), Part 1: Liver Transplant Oversight and Management Around the World

• Presenter: Scott Biggins, MD

Multiomic Approaches to Metabolic Dysfunction-Associated Steatotic Liver Disease

• Moderator: Satdarshan (Paul) Monga, MD

MTE #13 Parenteral Nutrition-Associated Liver Disease in Pediatrics: Recent Advances in Pathogenesis and Management

• Discussion Leader: Vikram Raghu, MD, MS

HepatoTalk: Navigating Difficult Conversations Between Clinicians, Patients, and Families

• Presenter: Amar Bansal, MD
• Moderator: Alison Faust, MD

MTE #18 Liver Regeneration Fibrosis: The Role of Liver Regeneration in Both Fibrosis Progression and Regression

• Discussion Leader: George Michalopoulos, MD, PhD

Basic Science Workshop, Ribonucleic Acid Nanomedicine: Reprogramming Cells to Transform Liver Outcomes, Part 1—Cutting-Edge Tools for Liver Gene Editing

• Moderator: Reben Raeman, MS, PhD

Basic Science Workshop, Ribonucleic Acid Nanomedicine: Reprogramming Cells to Transform Liver Outcomes, Part 2—Transforming Chronic Liver Disease: Breakthroughs and Clinical Updates in Ribonucleic Acid Nanotherapeutics

• Moderator: Reben Raeman, MS, PhD
• Invited Talk: Satdarshan (Paul) Monga, MD

Hepatotoxicity and Pediatric Liver Disorders: Special Interest Groups Joint Symposium, Part 1. Drug-Induced Liver Injury: Drug-Induced Liver Injury Across the Lifespan—Advances in Management

• Moderator: James E. Squires, MD, MS

Patient Engagement in Pediatric Liver Disease: Experiences From the A-LiNK, PFIC.org, and Starzl Networks

• Presenter and Moderator: James E. Squires, MD, MS

My Personal Experience with Palliative Care

• Presenter: Karl Bezak, MD

Cellular Catalysts of Fibrosis: Stromal Signals, Exosomes, and Inflammation in the Diseased Liver

• Moderator: Vik Meadows, PhD

Liver Cell Biology SIG Poster Highlights

• Moderator: Kari Nejak-Bowen, MBA, PhD

Clinical Management of Portal Hypertensive Complications: Hepatic Encephalopathy and Renal Failure

• Moderator: Scott Biggins, MD

MTE #41 What's New in Pediatric Liver Transplant Guidelines

• Discussion Leader: Simon Horslen, MD

Early Career Investigator Essentials: Adapting and Excelling in Challenging Times

• Invited Talk: Shari S. Rogal, MD, MPH

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Abstracts presented by UPMC and Pitt researchers include:

0071 | INDUCIBLE DUAL LOSS OF β- AND γ-CATENIN IN BILE DUCTS LEADS TO CHOLESTATIC INJURY AND MORTALITY OR REPAIR BASED ON THE EXTENT OF CELL JUNCTION LOSS

Vik Meadows¹Yekaterina Krutsenko¹Elena Provencal¹Minakshi Poddar¹Sucha Singh¹Satdarshan (Paul) Monga¹, ¹University of Pittsburgh

0085 | PATIENT-REPORTED SYMPTOM BURDEN AS A PREDICTOR OF HOSPITALIZATIONS IN A MULTISITE COHORT OF PATIENTS WITH ADVANCED LIVER DISEASE: RESULTS: FROM THE PACE-LT CONSORTIUM

Nneka Ufere¹Elizabeth Aby²Chengbo Zeng³Grace Bizup¹Enya Zhu⁴Michael Kriss⁵Jon Rice⁶Thomas Leventhal²Deepika Devuni⁷Anita Krishnarao⁷Brett Fortune⁸Clara Tow⁹Paola Mejia⁹Lindsay King¹⁰Jacqueline Henson⁴Sarah Lieber¹¹Alvaro Noriega Ramirez¹¹Lauren Nephew¹²Patricia Jones¹³Nathaly Cortez Bazan¹³Melanie Hundt⁹Kali Zhou¹⁴Hyosun Han¹⁴Hersh Shroff¹⁵Krista Hunt¹⁵Shari Rogal¹⁶Alan Noll¹Stela Celaj¹⁷Areej Mazhar¹⁸Dempsey Hughes¹⁸Anushka Dalvi¹Malia Armstrong¹Lucinda Li¹⁹Maria Edelen³Areej El-Jawahri¹, ¹Massachusetts General Hospital,²University of Minnesota,³Brigham and Women's Hospital,⁴Duke University,⁵University of Colorado School of Medicine,⁶University of Colorado,⁷University of Massachusetts,⁸Montefiore Medical Center,⁹Montefiore,¹⁰Duke University School of Medicine,¹¹UTSW,¹²Indiana University,¹³University of Miami,¹⁴USC,¹⁵UNC Chapel Hill,¹⁶University of Pittsburgh,¹⁷UPMC,¹⁸Northwestern,¹⁹UCLA

0102 | GETTING TO IMPLEMENTATION: A STEPPED WEDGE CLUSTER RANDOMIZED TRIAL OF A HOSPITAL-LEVEL INTERVENTION TO IMPROVE HEPATOCELLULAR CARCINOMA SURVEILLANCE

vera yakovchenko¹Chaeryon Kang²Brittney Neely¹Carolyn Lamorte¹Heather McCurdy³Dawn Scott⁴Anna Nobbe⁵Gwen Robins⁶Nsikak Ekanem⁷Monica Merante¹Sandra Gibson¹Patrick Spoutz⁸Linda Chia⁸Rachel Gonzalez⁹matthew chinman¹⁰David Ross¹¹Maggie Chartier¹¹Lauren Beste¹²Jasmohan Bajaj¹³Tamar Taddei¹⁴Timothy Morgan¹⁵Shari Rogal¹, ¹VA Pittsburgh Healthcare System,²University of Pittsburgh,³VA Ann Arbor,⁴Central Texas Veterans Healthcare System,⁵Cincinnati VA Medical Center,⁶Martinsburg VA Medical Center,⁷VA Northern Indiana Healthcare System,⁸Veterans Integrated Service Network 20,⁹Sierra Pacific Veterans Integrated Service Network,¹⁰RAND Corporation,¹¹Veterans Health Administration,¹²VA Puget Sound Health Care System,¹³Central Virginia VA Health Care System,¹⁴VA Connecticut Healthcare System,¹⁵VA Long Beach Healthcare System

0204 | FRACTURES IN PATIENTS WITH ALAGILLE SYNDROME: DATA FROM THE GALA STUDY GROUP

Andrew Wehrman¹Quinn Rabenau-McDonnell²Desiree Vaz³David Weber²Kathleen Loomes²Emmanuel Gonzales⁴Emmanuel Jacquemin⁴Jérôme Bouligand⁵Irena Jankowska⁶Piotr Czubkowski⁶Dorota Gliwicz-Miedzi?ska⁶David Piccoli²Etienne Sokal⁷Giulia Jannone⁷Susan Siew⁸Michael Stormon⁸Noelle Ebel⁹Jeffrey Feinstein¹⁰Amal Aqul¹¹Nathalie Rock¹²Bjorn Fischler¹³Henrik Arnell¹⁴Amin Roberts¹⁵Helen Evans¹⁵Henry Lin¹⁶Jian-She Wang¹⁷Rima Fawaz¹⁸Silvia Nastasio¹⁹Ryan Fischer²⁰Dominique DEBRAY²¹Florence Lacaille²¹Lorenzo D'Antiga²²Emanuele Nicastro²³Winita Hardikar²⁴sahana shankar²⁵Henkjan Verkade²⁶Catherine Larson-Nath²⁷cigdem arikan²⁸James Squires²⁹Marisa Beretta³⁰Saul Karpen³¹Rene Romero³²Shikha Sundaram³³Deirdre Kelly³⁴Jane Hartley³⁴Christina Hajinicolaou³⁵ELISA Carvalho³⁶Pamela Valentino³⁷Arti Pawaria³⁸Nanda Kerkar³⁹M. Jensen⁴⁰Catalina Jaramillo⁴⁰María-Camila Sanchez⁴¹Maria Lorena Cavalieri⁴¹Chatmanee Lertudomphonwanit⁴²yael mozer glassberg⁴³Ruben Quiros-Tejeira⁴⁴Melina Melere⁴⁵Pinar Bulut⁴⁶Pier Luigi Calvo⁴⁷Miray Karakoyun⁴⁸John Eshun⁴⁹Andréanne Zizzo⁵⁰Jenn Garcia⁵¹Kathleen Schwarz⁵²Kyung Mo Kim⁵³Seak Hee Oh⁵³Nehal El Koofy⁵⁴Mohamed Elmonem⁵⁴Way Seah Lee⁵⁵Seema Alam⁵⁶Jesus Quintero Bernabeu⁵⁷Mureo Kasahara⁵⁸Regino Gonzalez-Peralta⁵⁹Giuseppe Indolfi⁶⁰Zerrin Önal⁶¹Aglaia Zellos⁶²Wikrom Karnsakul⁶³Victorien Wolters⁶⁴Antal Dezsofi-Gottl⁶⁵Sabina Wiecek⁶⁶Gabriella Nebbia⁶⁷Raquel Borges-Pinto⁶⁸Maria Rogalidou⁶⁹Maria Legarda⁷⁰Niviann Blondet³⁷Simone Kortbeek⁷¹Thomas Sandahl⁷²Anna-Maria Kavallar⁷³Cristina Gonçalves⁷⁴Jernej Brecelj⁷⁵Cristina Molera⁷⁶Eberhard Lurz⁷⁷Ermelinda Santos-Silva⁷⁸Quais Mujawar⁷⁹Christos Tzivinikos⁸⁰Carolina Jimenez-Rivera⁸¹Luis Bujanda⁸²Vaidotas Urbonas⁸³Silvia Morise⁸⁴Richard Thompson⁸⁵Bettina Hansen⁸⁶Binita Kamath⁸⁷, ¹Boston Childrens Hospital,²Children's Hospital of Philadelphia,³The Hospital for Sick Children,⁴Bicêtre Hospital,⁵Centre Hospitalier Universitaire de Bicêtre,⁶The Children's Memorial Health Institute,⁷Cliniques Universitaires Saint-Luc,⁸The Children’s Hospital at Westmead,⁹Stanford University School of Medicine,¹⁰Stanford University School of Medicine, Lucile Packard Children’s Hospital,¹¹University of Texas Southwestern Medical Center,¹²University Hospitals Geneva and University of Geneva,¹³Astrid Lindgren Children's Hospital, Karolinska University Hospital and CLINTEC,¹⁴Astrid Lindgren Children's Hospital, Karolinska University Hospital, Karolinska Institutet,¹⁵Starship Child Health,¹⁶Oregon Health and Science University,¹⁷Children's Hospital of Fudan University,¹⁸Yale University School of Medicine,¹⁹Boston Children’s Hospital and Harvard Medical School,²⁰Children's Mercy Kansas City,²¹Necker‐Enfants Malades Hospital, University of Paris,²²1) Ospedale Papa Giovanni XXIII, 2) University of Milano,²³Ospedale Papa Giovanni XXIII,²⁴Royal Children's Hospital,²⁵Mazumdar Shaw Medical Center, Narayana Health,²⁶University Medical Center Groningen, University of Groningen,²⁷University of Minnesota,²⁸Koc University School of Medicine,²⁹University of Pittsburgh School of Medicine,³⁰Wits Donald Gordon Medical Centre, University of the Witwatersrand,³¹1) Children's Healthcare of Atlanta 2) Virginia Commonwealth University,³²Children's Healthcare of Atlanta & Emory University School of Medicine,³³Children's Hospital Colorado and University of Colorado School of Medicine,³⁴Birmingham Women's & Children's Hospital NHS Trust and University of Birmingham,³⁵Chris Hani Baragwanath Academic Hospital, University of Witwatersrand,³⁶Hospital da Crianca de Brasilia, Centro Universitario de Brasilia,³⁷University of Washington, Seattle Children's Hospital,³⁸Sir H.N. Reliance Foundation Hospital & Research Center,³⁹1) Massachusetts General Brigham for Children, 2) University of Rochester Medical Center,⁴⁰University of Utah, Primary Children's Hospital,⁴¹Hospital Italiano Buenos Aires,⁴²Ramathibodi Hospital Mahidol University,⁴³Schneider Children's Medical Center of Israel,⁴⁴Children's Nebraska and University of Nebraska Medical Center,⁴⁵Universidade Federal de Ciencias da Saude de Porto Alegre, Complexo Hospitalar Santa Casa,⁴⁶Phoenix Children's Hospital,⁴⁷Regina Margherita Children's Hospital,⁴⁸Ege University Medical School,⁴⁹Le Bonheur Children’s Hospital and The University of Tennessee Health Science Center,⁵⁰Children's Hospital, London Health Sciences Centre, Western University,⁵¹Miami Transplant Institute, University of Miami,⁵²University of California San Diego, Rady Children's Hospital San Diego,⁵³University Of Ulsan College of Medicine, Asan Medical Center Children's Hospital,⁵⁴Cairo University,⁵⁵University of Malaya,⁵⁶Institute of Liver and Biliary Sciences,⁵⁷1) Hospital Universiatri Vall d'Hebron, 2) ERN RARE-LIVER, 3) ERN-TransplantChild,⁵⁸National Center for Child Health and Development,⁵⁹University of Florida,⁶⁰Meyer Children's University Hospital IRCCS,⁶¹Istanbul University Istanbul Medical Faculty,⁶²Mitera Children's Hospital,⁶³Johns Hopkins University School of Medicine,⁶⁴University Medical Center Utrecht,⁶⁵Semmelweis University,⁶⁶Medical University of Silesia in Katowice,⁶⁷Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico,⁶⁸Hospital Crianca Conceicao,⁶⁹"Aghia Sofia" Children's Hospital, University of Athens,⁷⁰Cruces University Hospital,⁷¹Cumming School of Medicine, University of Calgary, Alberta Children's Hospital,⁷²1) Aarhus University Hospital 2) ERN-Rare Liver,⁷³Medical University of Innsbruck,⁷⁴1) ERN RARE-LIVER 2) Pediatric Gastroenterology/Hepatology Center,⁷⁵University Medical Center Ljubljana,⁷⁶Hospital Sant Joan de Deu,⁷⁷Dr. von Hauner Children's Hospital,⁷⁸1) Centro Hospitalar Universitario de Santo Antonio, 2) UCIBIO,⁷⁹University of Manitoba,⁸⁰Mohammed Bin Rashid University of Medicine and Health Sciences,⁸¹Children's Hospital of Eastern Ontario,⁸²Donostia University Hospital,⁸³Vilnius University Hospital,⁸⁴Jose C. Paz Buenos Aires,⁸⁵King's College London,⁸⁶1) Toronto General Hospital University Health Network, 2) Institute of Health Policy,⁸⁷1) Children's Hospital of Philadelphia, 2) The Hospital for Sick Children

0207 | ETIOLOGY OF PEDIATRIC ACUTE LIVER FAILURE IN PATIENTS SCREENED FOR THE TREATMENT FOR IMMUNE MEDIATED PATHOPHYSIOLOGY (TRIUMPH) TRIAL

Catherine Chapin¹Simon Horslen²Zemin Su³Anna Banc-Husu⁴Beth Carter⁵Jaime Chu⁶Tamir Diamond⁷Scott Elisofon⁸Ryan Fischer⁹M. Jensen¹⁰Steven Lobritto¹¹Mike Leonis¹²Amrita Narang¹³Anna Peters¹⁴Norberto Rodriguez-Baez¹⁵Rene Romero¹⁶Philip Rosenthal¹⁷David Rudnick¹⁸James Squires²Shikha Sundaram¹⁹Kyla Tolliver²⁰Pamela Valentino²¹Edward Behrens⁷Kathleen Loomes⁷Valerie Durkalski³Estella Alonso¹, ¹Ann & Robert H. Lurie Children's Hospital of Chicago,²UPMC Children's Hospital of Pittsburgh,³Medical University of South Carolina,⁴Baylor College of Medicine, Texas Children's Hospital,⁵Children's Hospital of Los Angeles, University of Southern California,⁶Icahn School of Medicine at Mount Sinai,⁷The Children's Hospital of Philadelphia,⁸Boston Childrens Hospital,⁹Children's Mercy Hospital,¹⁰University of Utah,¹¹Columbia University Medical Center,¹²Cleveland Clinic Children's Hospital,¹³Lucile Packard Children’s Hospital, Stanford University School of Medicine,¹⁴Cincinnati Children's Hospital Medical Center,¹⁵UT Southwestern Medical Center,¹⁶Emory University School of Medicine,¹⁷University of California, San Francisco,¹⁸Washington University Medical Center,¹⁹Children's Hospital Colorado,²⁰Indiana University,²¹Seattle Children's Hospital, University of Washington

0210 | OUTCOMES AFTER PEDIATRIC FIRST VARICEAL HEMORRHAGE – RESULTS: FROM 44 CENTERS PARTICIPATING IN THE INTERNATIONAL MULTICENTER PEDIATRIC PORTAL HYPERTENSION REGISTRY (IMPPHR)

Benjamin Shneider¹Xiaotian Gao²Kexin Guo²Catalina Jaramillo³Jean Molleston⁴Julio Pimenta⁵Oanez Ackermann⁶Riccardo Superina⁷Simon Ling⁸Akinari Hinoki⁹Alexandre Rodrigues Ferreira⁵Alexis Gumm¹⁰Amal Aqul¹¹Amy Feldman¹²Angelo Di Giorgio¹³Anita Pai¹⁴Anja Praprotnik Novak¹⁵Antoine Gardin¹⁶Carolina Jimenez-Rivera¹⁷César Ulises Amaro-Reynoso¹⁸Chaitri Desai¹⁹Dariaa Voroniak²⁰Denise Aldrian²¹Elizabeth BAnnister²²Eyal Shteyer²³Georg Friedrich Vogel²¹Giuseppe Indolfi²⁴H.P.J. van der Doef²⁵James Squires²⁶Jane Hartley²⁷Juan Cristóbal Gana²⁸Jesús Quintero-Bernabéu²⁹Jordache Taylor³⁰Katherine Sweeny³¹Kee-Seang Chew³²Keith Hazleton³³Lee Bass⁷Maria Margaret Mercadal-Hally²⁹Marianna Durilova³⁴Matjaž Homan³⁵Mercedes Martinez³⁶Mohit Kehar¹⁷Mureo Kasahara³⁷Oleg Godik²⁰Orith Waisbourd-Zinman³⁸Pamela Valentino³⁹Pooja Spector⁴⁰Rima Fawaz⁴¹Rodrigo Vázquez Frias¹⁸Ryuji Komine³⁷Sakil Kulkarni⁴²Samar Ibrahim⁴³Sarah Bedoyan⁴⁴Rustam Yuldashev⁴⁵Sarah Berkenfeld⁴⁶Sara Kathryn Smith⁴⁷Scott Elisofon³¹Shinya Yokoyama⁴⁸Simon Lam⁴⁹Simona Carrera²⁴songpon getsuwan⁵⁰Suporn Treepongkaruna⁵¹Thomai Kotsou⁵²Way-Seah Lee⁵³Voytek Slowik⁵⁴Wikrom Karnsakul⁵⁵Winita Hardikar⁵⁶Vera Hupertz⁵⁷Yael Mozer-Glassberg³⁸Jaume Bosch⁵⁸Roberto De Franchis⁵⁹Tassos Grammatikopoulos⁶⁰, ¹Texas Children's Hospital,²Baylor College of Medicine,³University of Utah,⁴Indiana University/Riley Hospital for Children,⁵Hospital das Clínicas da UFMG,⁶Hepatologie et Transplantation Hepatique Pediatriques, Hopital Bicetre,⁷Ann and Robert H. Lurie Children's Hospital of Chicago,⁸University of Toronto/SickKids Hospital,⁹Department of Pediatric Surgery, Graduate School of Medicine, Nagoya University,¹⁰Medical College of Wisconsin,¹¹University of Texas Southwestern Medical Center,¹²University of Colorado,¹³University of Udine,¹⁴Vanderbilt University,¹⁵University Children's Hospital Ljubljana,¹⁶Hepatologie et Transplantation Hepatique Pediatriques, Hopital Bicetre, AP-HP,¹⁷University of Ottawa,¹⁸Hospital Infantil de México Federico Gómez,¹⁹Children’s Mercy – Kansas City,²⁰National Children Specialized Hospital “Okhmatdyt”,²¹Medical University of Innsbruck,²²Royal Children's Hospital, Melbourne,²³Shaare Zedek Medical Center,²⁴Meyer Childen's Hospital IRCCS,²⁵University Medical Center Groningen,²⁶Children's Hospital of Pittsburgh,²⁷Birmingham Women's and Children's Hospital,²⁸Pontificia Universidad Católica de Chile,²⁹Vall d'Hebron Hospital,³⁰King's College Hospital NHS Foundation Trust,³¹Boston Childrens Hospital,³²University Malaya,³³Children’s Hospital Los Angeles,³⁴University Hospital Motol,³⁵University Children's Hospital, University of Ljubljana,³⁶NewYork-Presbyterian,³⁷National Center for Child Health and Development,³⁸Schneider Children’s Medical Center,³⁹University of Washington,⁴⁰Columbia University,⁴¹Yale University,⁴²Washington University in St. Louis,⁴³Mayo Clinic Rochester,⁴⁴UPMC Children’s Hospital of Pittsburgh,⁴⁵Republican Specialized Scientific Practical Medical Center of Pediatrics,⁴⁶Wits Donald Gordon Medical Centre,⁴⁷The Johns Hopkins University School of Medicine,⁴⁸Nagoya University,⁴⁹University of Calgary,⁵⁰songpon@mahidol.edu,⁵¹Mahidol University,⁵²University of Groningen,⁵³University Tunku Abdul Rahman,⁵⁴Children's Mercy Hospital,⁵⁵Johns Hopkins University,⁵⁶Royal Children's Hospital,⁵⁷Cleveland Clinic Foundation,⁵⁸Universitat Bern,⁵⁹University of Milan,⁶⁰King's College Hospital

0237 | SALIVARY MICROBIOME AND SERUM METABOLOMICS ADD TO CLINICAL BIOMARKERS TO PREDICT 6-MONTH HOSPITALIZATIONS IN A MULTI-CENTER CIRRHOSIS OUTPATIENT COHORT

Jasmohan Bajaj¹K Rajender Reddy²Jennifer Lai³Jacqueline O'Leary⁴Puneeta Tandon⁵Florence Wong⁶Guadalupe Garcia-Tsao⁷Hugo Vargas⁸Patrick Kamath⁹Scott Biggins¹⁰Philip Vutien¹¹Ana Limon-Moro¹²Jawaid Shaw¹³Masoumeh Sikaroodi¹⁴Brian Bush¹⁵Leroy Thacker¹⁵Patrick Gillevet¹⁴, ¹Virginia Commonwealth University,²University of Pennsylvania,³UCSF,⁴Dallas VA,⁵University of Alberta,⁶University of Toronto,⁷Yale University,⁸Mayo Clinic Arizona,⁹Mayo Rochester,¹⁰UPMC,¹¹UW Seattle,¹²U Alberta,¹³Richmond VA,¹⁴GMU,¹⁵VCU

0244 | INTEGRIN α₄β₇ PROMOTES REPAIR AND REGENERATION IN ACETAMINOPHEN-INDUCED LIVER INJURY BY RECRUITING MONOCYTES AND DRIVING THEIR PRO-REPARATIVE PROGRAMMING

Reben Raeman¹Ravi Rai¹PABITRA PAL¹Daniel Rossmiller¹Smita Iyer¹Michael Oertel¹, ¹University of Pittsburgh

 1015 | HEPATIC STELLATE CELL-DERIVED WNTS CONTROL LIVER HOMEOSTASIS AND METABOLISM

Nicholas Khoo¹Tyler Yasaka¹Minakshi Poddar¹Sucha Singh¹Aaron Bell¹Ravi Rai¹Ian Sipula¹Amber Vandevender¹Xiachao Ma¹Reben Raeman¹Silvia Liu¹Michael Jurczak¹Satdarshan (Paul) Monga¹, ¹University of Pittsburgh

1051 | ALTERNATIVELY SPLICED TISSUE FACTOR: A NOVEL CONTRIBUTOR TO MASLD PROGRESSION

Clayton Lewis¹Kateryna Stone¹Sabahat Ahsan¹Josepha Sedzro²Lanuza Faccioli³Zhiping Hu³Rodrigo Florentino³Alejandro Soto-Gutierrez³Jiang Wang¹James Luyendyk⁴, ¹University of Cincinnati,²University of Michigan,³University of Pittsburgh,⁴Michigan State University

1058 | ERBB3 IS A NOVEL THERAPEUTIC TARGET FOR METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

Shehnaz Bano¹Bharat Bhushan¹George Michalopoulos¹Anne Orr¹John Stoops¹Shirish Paranjpe¹Joseph Locker¹Alejandro Soto-Gutierrez¹Rodrigo Florentino¹, ¹University of Pittsburgh

1076 | REDUCED ZMPSTE24 EXPRESSION LEADS TO PRELAMIN ACCUMULATION AND DEVELOPMENT OF STEATOSIS IN MASLD PATIENTS

Joseph Schinderle¹Irina Bochkis¹, ¹University of Pittsburgh

1380 | CUMULATIVE REVIEW OF SOFOSBUVIR/VELPATASVIR EXPOSURE IN PREGNANT WOMEN WITH HEPATITIS C VIRUS FROM A PHARMACOVIGILANCE SAFETY DATABASE

Stacey Scherbakovsky¹Catherine Chappell²Chelsea Elwood³Yachna Sahi⁴Frederick Pitts⁴Lauren Liu⁴Catherine Frenette⁵Tatyana Kushner⁶, ¹Gilead Sciences, Inc,²University of Pittsburgh; Magee-Womens Research Institute,³Medical Lead Oak Tree Clinic and Antimicrobial Stewardship BC Women’s Hospital and Health Centre,⁴Gilead Sciences,⁵Gilead Sciences, Inc.,⁶Weill Cornell Medicine

1524 | CHARACTERIZATION OF PLASMA PEPTIDOMIC SIGNATURES INVOLVED IN THE GUT-IMMUNE-LIVER AXIS OF THE EARLY-STAGE ALCOHOL-ASSOCIATED LIVER DISEASE

Anjali Kumari¹Mukesh Kumar Sriwastva¹Christine Dolin¹Michael Merchant¹Gavin Arteel²Maiying Kong¹Melanie Schwandt³Joris Verster¹Venkatakrishna Jala¹Ashwani Singal¹Craig McClain¹Vatsalya Vatsalya¹, ¹University of Louisville,²University of Pittsburgh,³NIAAA

1553 | COMPARATIVE EFFECTIVENESS OF BARIATRIC SURGERY VERSUS GLP-1 RECEPTOR AGONISTS IN PATIENTS WITH METABOLIC DYSFUNCTION–ASSOCIATED ALCOHOL-RELATED LIVER DISEASE

Amir Hossein Gougol¹Paul Kwo²Seyedbabak Mirminachi³Willian Pike⁴Mehdi Farokhnia⁵, ¹Stanford,²Stanford University Medical Center,³University of Pittsburgh Medical Center,⁴Atropos Health,⁵NIH

1583 | AREA-LEVEL DEPRIVATION STRONGLY CONTRIBUTES TO DISPARITIES IN ACCESS TO LIVER TRANSPLANTATION AND OUTCOMES AMONG PATIENTS WITH SEVERE ALCOHOL-ASSOCIATED HEPATITIS: RESULTS: FROM A PROSPECTIVE MULTICENTER STUDY

Lauren Nephew¹Thomas Cotter²Ashwani Singal³Juan Pablo Arab⁴Jaideep Behari⁵Qing Tang⁶Samer Gawrieh⁷Wanzhu Tu⁷Naga Chalasani⁸, ¹Indiana University,²UT Southwestern Medical Center,³University of Louisville,⁴Virginia Commonwealth University,⁵University of Pittsburgh Medical Center,⁶Departmen tof Biostatitics & Health Data Science, Indiana University School of Medicine,⁷Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of,⁸Indiana University Medical Center

1585 | CALPAIN INHIBITION ATTENUATES EXPERIMENTAL ALCOHOL-INDUCED LIVER INJURY THROUGH REGULATION OF CHOLESTEROL METABOLISM

Noriko Kitano¹Jiang Li¹Charis-Marie Vanderpuye¹Pooja Muddasani¹Yekaterina Krutsenko¹Hamda Siddiqui¹Samuel Taborski¹Juliane Beier¹Gavin Arteel¹, ¹University of Pittsburgh

2204 | SEX FOR THE PURPOSES OF MELD 3.0 CALCULATION: WHEN THIS DIFFERS FROM ASSIGNED SEX AT BIRTH AND IMPLICATIONS FOR POLICY

Nikki Duong¹Daniel Huynh²Newsha Nikzad³W. Ray Kim⁴Neil Shah⁵Scott Biggins⁶Allison Kwong⁷, ¹Stanford University,²University of Washington,³The University of Chicago Medical Center,⁴Mayo Clinic Arizona,⁵University of North Carolina at Chapel Hill,⁶University of Pittsburgh,⁷Stanford University Medical Center

2324 | A MACHINE LEARNING MODEL TO REDUCE UNNECESSARY PARACENTESIS FOR SBP EXCLUSION HAS EXCELLENT PERFORMANCE IN A RECENT NATIONWIDE CIRRHOSIS COHORT

Jacqueline O'Leary¹Jasmohan Bajaj²Scott Silvey²Nilang Patel²Heather Patton³Timothy Morgan⁴Sofia Jakab⁵Shari Rogal⁶, ¹Dallas VAMC,²Virginia Commonwealth University,³VA San Diego Healthcare,⁴VA Long Beach Healthcare System,⁵West Haven VA,⁶University of Pittsburgh

2453 | OPERATIONALIZING A WALKING EXERCISE PRESCRIPTION BASED ON 6-MINUTE WALK TEST RESULTS:

Joshua Sepic¹Louis Guzman²Susanna Miranda¹Fei-Pi Lin³Pamela Bloomer⁴Richard Lieber⁵James Sliwa⁵Andres Duarte-Rojo¹, ¹Northwestern Medicine,²Northwestern University,³University of Pittsburgh,⁴University of Pittsburgh Medical Center,⁵Shirley Ryan Ability Lab

2593 | SIGNIFICANT DIFFERENCES IN DIETARY PATTERNS BETWEEN RURAL VERSUS URBAN PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: A PROSPECTIVE STUDY

Swetha Tummala¹Trevor Dean¹Renwei Wang¹Jessica Izenas¹Olivia Popovich¹Oscar Shaver¹Olivia Hansol Lee¹Jian-Min Yuan¹Jaideep Behari¹, ¹University of Pittsburgh

3026 | HEPATITIS C TREATMENT EXPOSURE IN PREGNANCY: THREE-YEAR EXPERIENCE FROM THE “TIP-HEPC” CLINICAL CASE REGISTRY

Neil Gupta¹Lindsey Hiebert¹Jana Manning¹Saeed Hamid²Manal El-Sayed³Ravi Jhaveri⁴Ali Judd⁵Tatyana Kushner⁶Mia Biondi⁷Catherine Chappell⁸John Ward⁹, ¹Coalition for Global Hepatitis Elimination, The Task Force for Global Health,²Department of Medicine, Aga Khan University, Karachi, Pakistan,³Pediatric Department, Ain Shams University and Clinical Research Center, Faculty of Medicine, Ain,⁴Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,⁵University College London, London, UK; Fondazione Penta ETS, Padova, Italy,⁶Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, USA,⁷School of Nursing, York University Viral Hepatitis Care Network, University Health Network,⁸Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, PA,⁹Coalition for Global Hepatitis Elimination

3326 | TRENDS AND FACTORS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA DIAGNOSIS, STAGE, TREATMENT AND SURVIVAL

George Ioannou¹vera yakovchenko²Tamar Taddei³Alexander Monto⁴Heather Patton⁵Monica Merante²Patrick Spoutz⁶Linda Chia⁶Jennifer Yudkevich⁷Ayse Aytaman⁸Atoosa Rabiee⁹Binu John¹⁰Boris Blechacz¹¹Cincy Cai¹²HoChong Gilles¹³Anand Shah¹⁴Heather McCurdy¹⁵Puneet Puri¹⁶Janice Jou¹⁷Khurram Mazhar¹⁸Cesar Taborda-Vidarte¹⁹Sujan Ravi²⁰Alpna Limaye²¹Amar Mandalia²²Karlyn Rupert²³Jason Dominitz²⁴Jennifer Anwar²⁵Timothy Morgan²⁶Shari Rogal²⁷, ¹University of Washington Medical Center,²VA Pittsburgh Health Care System,³Yale University,⁴University of California, San Francisco,⁵VA San Diego Health Care System,⁶Pharmacy Benefits Management, Veterans Integrated Service Network 20, Vancouver, WA,⁷VA New York Harbor Healthcare System, Brooklyn, NY,⁸VA NY Harbor Healthcare System Brooklyn Campus,⁹Washington DC VA Medical Center,¹⁰University of Miami and Miami VA,¹¹VA South Texas Health Care System, San Antonio, TX,¹²VA Loma Linda,¹³McGuire Veterans Affairs Medical Center,¹⁴VA Atlanta,¹⁵VA Ann Arbor,¹⁶VA Richmond,¹⁷OHSU,¹⁸VA North Texas Health Care System, Dallas, TX,¹⁹VA Tampa,²⁰Birmingham VA Medical Center, Birmingham, AL,²¹Gainesville VA,²²Orlando VA Medical Center, Orlando, FL,²³VA Martinsburg Health Care System,²⁴VA Puget Sound,²⁵VA Long Beach,²⁶VA Long Beach Healthcare System,²⁷University of Pittsburgh

3472 | SPATIAL MOLECULAR ANALYSIS REVEALS NOVEL MECHANISMS AND CELLULAR PARTICIPANTS IN THE PROGRESSION OF ANTIBODY-MEDIATED LIVER ALLOGRAFT INJURY.

Mylarappa Ningappa¹Catherine Gestrich²Brandon Higgs¹Lori Schmitt²Kyle Soltys¹George Mazariegos,¹Chethan Ashokkumar¹Rakesh Sindhi¹, ¹Children's Hospital of Pittsburgh of UPMC, Hillman Center for Pediatric Transplantation,²Children's Hospital of Pittsburgh of UPMC, Department of Pathology

3483 | A RANDOMIZED MULTI-CENTER TRIAL OF A TELEMETRIC INTERVENTION TO PREVENT REJECTION IN ADOLESCENTS AT RISK AFTER LIVER TRANSPLANTATION (IMALT)

Eyal Shemesh¹Ravinder Anand²Rachel Annunziato¹Emily Fredericks³Jennifer Garcia⁴Nitika Gupta⁵Alyssa Kriegermeier⁶Krupa Mysore⁷Vicky Ng⁸Steven Lobritto⁹Shreena Patel¹⁰Emily Perito¹¹Elizabeth Rand¹²Rene Romero⁵Robert Venick¹³Sarah Duncan-Park¹Jeffrey Mitchell²Sarah Anderson²Margaret Stuber¹⁴Miguel Reyes-Múgica¹⁵George Mazariegos¹⁶Benjamin Shneider¹⁷, ¹Icahn School of Medicine at Mount Sinai,²The Emmes Company, LLC,³University of Michigan Medical Center,⁴Miami Transplant institute, University of Miami,⁵Emory University School of Medicine,⁶Ann and Robert H. Lurie Children's Hospital of Chicago,⁷Baylor College of Medicine,⁸Hospital for Sick Children,⁹Columbia University,¹⁰Children’s Hospital Los Angeles | USC Keck School of Medicine,¹¹Benioff Children's Hospital University of California, San Francisco,¹²Children's Hospital of Philadelphia / University of Pennsylvania,¹³David Geffen School of Medicine at UCLA,¹⁴UCLA David Geffen School of Medicine,¹⁵University of Miami, Miller School of Medicine,¹⁶Children's Hospital of Pittsburgh,¹⁷Texas Children's Hospital

3585 | EPIDEMIOLOGIC DIFFERENCES IN HIGH-RISK CYTOMEGALOVIRUS MISMATCH BETWEEN ADULT AND PEDIATRIC LIVER TRANSPLANT (LT) RECIPIENTS

Vikram Raghu¹James Squires²Kyle Soltys³Simon Horslen³George Mazariegos²Rakesh Sindhi³, ¹University of Pittsburgh School of Medicine,²Children's Hospital of Pittsburgh,³UPMC Children's Hospital of Pittsburgh

4023 | INCRETIN MIMETIC THERAPY IN PATIENTS WITH MASLD IS ASSOCIATED WITH EARLY BODY COMPOSITION CHANGES WITH BLUNTING OF DIFFERENCES WITH LONGER-TERM TREATMENT

Oscar Shaver¹Renwei Wang¹Jessica Izenas¹Olivia Popovich¹Trevor Dean¹Olivia Hansol Lee¹Jian-Min Yuan¹Jaideep Behari¹, ¹University of Pittsburgh

4125 | SECONDARY SBP PROPHYLAXIS WORSENS SURVIVAL WITHOUT AFFECTING LIVER TRANSPLANT RATES IN VETERANS WITH CIRRHOSIS FOLLOWED AFTER THEIR FIRST DECOMPENSATION

Shari Rogal¹Jasmohan Bajaj²Scott Silvey³Nilang Patel⁴Jacqueline O'Leary⁵Timothy Morgan⁶John Markley⁷Sofia Jakab⁸Heather Patton⁹, ¹University of Pittsburgh,²Virginia Commonwealth University,³VCU,⁴Richmond VA,⁵Dallas VA,⁶VA Long Beach Healthcare System,⁷Richmond VAMC,⁸West Haven VA,⁹VA San Diego Healthcare

4192 | LOSS OF B-CATENIN IN CHOLANGIOCYTES PROMOTES ANGIOGENESIS AND HEPATOCYTE REPROGRAMMING DURING MURINE CHOLESTASIS

Matthew Carson¹Jamie Fornsaglio²Laura Molina¹Pamela Cornuet¹Jia-jun Liu¹Silvia Liu¹Kari Nejak-Bowen¹, ¹University of Pittsburgh,²Seton Hull University

4197 | IMPAIRING BILE DUCT FORMATION DISRUPTS HEPATIC ARTERY FORMATION IN A MOUSE MODEL OF GENETIC CHOLESTASIS

Laura Molina¹Tyler Yasaka¹Mara Sullivan¹Akshita Piedy¹Shuchang Liu¹Lori Schmitt²Catherine Gestrich²Kari Nejak-Bowen¹, ¹University of Pittsburgh,²Children's Hospital of Pittsburgh

4199 | SPATIOTEMPORAL RELATIONSHIP BETWEEN WNT/Β-CATENIN AND YAP SIGNALING PATHWAYS IN A CHOLESTATIC MOUSE MODEL

Veronica Lee¹Kari Nejak-Bowen¹, ¹University of Pittsburgh

4207 | MORE THAN JUST LIVER: ELUCIDATING GENETIC AND CHOLESTATIC CAUSES OF CHRONIC KIDNEY DISEASE IN A MOUSE MODEL OF BILE DUCT PAUCITY

Laura Molina¹Jia-jun Liu¹Akshita Piedy¹Shuchang Liu¹Jianhua Luo¹Minakshi Poddar¹Sucha Singh¹Pamela Cornuet¹Kari Nejak-Bowen¹, ¹University of Pittsburgh

4211 | EXPLORING THE ROLE OF THE WNT SIGNALING PATHWAY IN AN ALAGILLE MOUSE MODEL OF CHOLESTATIC LIVER DISEASE

Sarah Bedoyan¹Kari Nejak-Bowen²Pamela Cornuet², ¹University of Pittsburgh Medical Center,²University of Pittsburgh

4212 | BETA-CATENIN OVEREXPRESSION DAMPENS HEPATITIS, FIBROSIS, AND DUCTULAR PROLIFERATION IN A MOUSE CHOLESTATIC LIVER DISEASE MODEL AND COINCIDES WITH INCREASED HEPATOCYTE-TO-CHOLANGIOCYTE TRANSDIFFERENTIATION

Tony (Chun-Cheng) Chiang¹Pamela Cornuet¹Kari Nejak-Bowen¹, ¹University of Pittsburgh

4219 | HYPOXIA-INDUCIBLE FACTOR SIGNALING IN ENDOTHELIAL CELLS IS REQUIRED TO MAINTAIN NORMAL LIVER HOMEOSTASIS AND FOR REGENERATION AFTER PARTIAL HEPATECTOMY

Chang Kyung (Joanna) Kim¹Prerna Chakkingal²Minakshi Poddar²Sucha Singh²Satdarshan (Paul) Monga², ¹UPMC,²University of Pittsburgh

4232 | ZONE-SPECIFIC Β-CATENIN EXPRESSION IS REQUIRED FOR MAINTENANCE OF LIVER ZONATION AND REGENERATION AFTER PARTIAL HEPATECTOMY

Chang Kyung (Joanna) Kim¹Prerna Chakkingal¹Vik Meadows²Tyler Yasaka¹Minakshi Poddar¹Sucha Singh¹Satdarshan (Paul) Monga², ¹UPMC,²University of Pittsburgh

4243 | MZB1 ORCHESTRATES HEPATIC REGENERATION: ESSENTIAL ROLE IN CELL CYCLE PROGRESSION FOLLOWING LIVER INJURY

Jiang Li¹Noriko Kitano¹Sudrishti Chaudhary¹Samuel Taborski¹Juliane Beier¹Oliver Eickelberg¹Marta Bueno¹Gavin Arteel¹, ¹University of Pittsburgh

4260 | ZINC FINGER TRANSCRIPTION FACTOR FANIN IS THE UPSTREAM REGULATOR OF PIONEER FACTORS FOXA1 AND FOXA2 IN THE LIVER

Joseph Schinderle¹Anqi Wu¹Riya Shah¹Irina Bochkis¹, ¹University of Pittsburgh

4264 | LOSS OF APOE IN CCL19⁺ STROMAL CELLS EXACERBATES LIVER DAMAGE IN EXPERIMENTAL LUPUS HEPATITIS

Yekaterina Krutsenko¹Jiang Li¹Sudrishti Chaudhary¹Juliane Beier¹Gavin Arteel¹Catherine Poholek¹, ¹University of Pittsburgh

4273 | ECTOPIC ACTIVATION OF THE WNT/β-CATENIN/CYCLIN-D1 AXIS DURING EARLY LIVER REGENERATION

Tyler Yasaka¹Brandon Lehrich¹Shuchang Liu¹Satdarshan (Paul) Monga¹, ¹University of Pittsburgh

4278 | INFERRING SPATIAL SUBTYPE SIGNATURES OF HEPATOCELLULAR CARCINOMA FROM HISTOLOGIC IMAGES: A COMPUTATIONAL PATHOLOGY APPROACH

Tyler Yasaka¹Po-Yuan Chen¹Rebekah Dadey¹Riyue Bao¹Satdarshan (Paul) Monga¹Yu-Chiao Chiu¹, ¹University of Pittsburgh

4302 | MAPPING THE UNKNOWNS IN TUMOR EVOLUTION: SPATIAL TRANSCRIPTOMIC INSIGHTS INTO GENE EXPRESSION HETEROGENEITY AT THE HCC–DYSPLASTIC NODULE INTERFACE

Nigar Khurram¹, ¹University of Pittsburgh

4312 | EXTENT OF BILIARY β- AND γ-CATENIN LOSS REGULATES INTESTINAL INFLAMMATION AND MICROBIOME DYSBIOSIS IN CHOLESTATIC MICE

Vik Meadows¹Chang Kyung (Joanna) Kim¹Elena Provencal¹Minakshi Poddar¹Satdarshan (Paul) Monga¹, ¹University of Pittsburgh

4322 | GUT MICROBIOME DERIVED SHORT CHAIN FATTY ACIDS INCREASE RISK OF HEPATOCELLULAR CARCINOMA

Sindhu Karnam¹Wei Jia²Renwei Wang³Jennifer Adams-Haduch³Woon-Puay Koh⁴Jaideep Behari⁵Jian-Min Yuan¹, ¹University of Pittsburgh, UPMC Hillman Cancer Center,²Li Ka Shing Faculty of Medicine, The University of Hong Kong,³UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA,⁴Yong Loo Lin School of Medicine, National University of Singapore,⁵University of Pittsburgh - Division of Gastroenterology, Hepatology and Nutrition

4323 | HIGHER PLASMA KYNURENINE-TRYPTOPHAN RATIO PREDICTS INCIDENT HEPATIC FIBROSIS IN WOMEN WITH HIV

Maria Duarte¹Phyllis Tien¹Audrey French²Seble Kassaye³Deborah Gustafson⁴Robert Burk⁵Steven Wolinksy⁶Mallory Witt⁷Yue Chen⁸Chloe Thio⁹Svenja Albrecht¹⁰Margaret Fischl¹¹Cecile Lahiri¹²Michelle Floris-Moore¹³Eric Seaberg¹⁴Jennifer Price¹Yifei Ma¹Ani Kardashian¹⁵, ¹University of California, San Francisco,²Stroger Hospital of Cook County,³Georgetown University,⁴State University of New York Downstate Health Sciences University,⁵Albert Einstein College of Medicine,⁶Northwestern Feinberg School of Medicine,⁷Geffen School of Medicine at UCLA,⁸University of Pittsburgh,⁹Johns Hopkins University School of Medicine,¹⁰University of Mississippi Medical Center,¹¹University of Miami Miller School of Medicine,¹²Emory University School of Medicine,¹³University of North Carolina Chapel Hill School of Medicine,¹⁴Johns Hopkins University Bloomberg School of Public Helath,¹⁵Keck School of Medicine at the University of Southern California

4325 | C-C MOTIF CHEMOKINE RECEPTOR 9 ABLATION WORSENS WHEREAS THERAPEUTIC BLOCKING PROTECTS MICE FROM WESTERN DIET-INDUCED STEATOHEPATITIS

Reben Raeman¹Daniel Rossmiller¹Ravi Rai¹Vineet Mahajan¹Michael Oertel¹, ¹University of Pittsburgh

4339 | DYSBIOSIS IN THE GUT-LIVER AXIS DRIVES BONE LOSS DURING CHOLESTATIC LIVER DISEASE

Matthew Carson¹Brooke Hutchison¹Jamie Fornsaglio¹Kari Nejak-Bowen¹, ¹University of Pittsburgh

4368 | SIMULATED MILITARY BURN PIT INHALATION EXPOSURES CAUSE RAPID-ONSET HEPATIC PATHOLOGY IN A RAT MODEL

Shannon Heinig¹Pooja Muddasani¹Charis-Marie Vanderpuye¹Anna Rutkowski¹Joshlyn Mensah¹Fodilat Ibraheem¹hamda siddiqui¹Donna Stolz¹William Goldsmith²Anand Ranpara²Thomas Batchelor²Timothy Nurkiewicz²Juliane Beier¹, ¹University of Pittsburgh,²West Virginia University

4374 | RUST BELT ENVIRONMENTAL TOXICANTS TRANSFORM WESTERN DIET FROM METABOLIC CHALLENGE TO HEPATOTOXIC CRISIS IN MICE

hamda siddiqui¹Shannon Heinig¹Pooja Muddasani¹Charis-Marie Vanderpuye¹Jiang Li¹Natalie Price¹Zachary Zimmerman¹Shuai Yuan¹Sudrishti Chaudhary¹Noriko Kitano¹Gavin Arteel¹Alison Sanders¹Juliane Beier¹, ¹University of Pittsburgh

4383 | REAL-TIME HEPATIC SURVEILLANCE IN RESIDENTS FOLLOWING THE EAST PALESTINE, OH CHEMICAL DISASTER

Olisa Okonkwo¹Alexander Monroe¹Kimberly Stello¹James Fabisiak¹Carla Ng¹Fredrick Schumacher²Maureen Lichtveld¹Juliane Beier¹, ¹University of Pittsburgh,²Case Western Reserve University

4504 | BOLD AND BOLD-EXT, THE FIRST GLOBAL PHASE III CLINICAL PROGRAM TO EVALUATE THE LONG-TERM EFFICACY AND SAFETY OF ODEVIXIBAT IN INFANTS WITH BILIARY ATRESIA AFTER KASAI HEPATOPORTOENTEROSTOMY – STUDY DESIGN AND CURRENT STATUS

Saul Karpen¹Jiakang Yu²Henkjan Verkade³Vicky Ng⁴Shan Zheng⁵Jesus Quintero⁶Andrew Wehrman⁷Amrita Narang⁸Ekkehard Sturm⁹Helen Evans¹⁰Fernando Alvarez¹¹Kathleen Loomes¹²Nadia Ovchinsky¹³Winita Hardikar¹⁴Reuven Cohen¹⁵Shikha Sundaram¹⁶Mathias Ruiz¹⁷Susan Siew¹⁸Antal Dezsofi-Gottl¹⁹Ruzaimie Noor²⁰Orith Waisbourd-Zinman²¹Debra Pan²²Jean Molleston²³Janis Stoll²⁴Emmanuel Gonzales²⁵Reha Artan²⁶Way Lee²⁷Jaime Chu²⁸Laura Bauman²⁹Philip Bufler³⁰Lorenzo D'Antiga³¹Mara Cananzi³²Florence Lacaille³³Madeleine Aumar³⁴Hayriye Gulsen³⁵Ryan Fischer³⁶Philip Rosenthal³⁷M Jensen³⁸Adebowale Adeyemi³⁹Ulrich Baumann⁴⁰Pier Luigi Calvo⁴¹Chayarani Kelgeri⁴²James Squires⁴³Henry Lin⁴⁴Alyssa Kriegermeier⁴⁵Michael Rogers⁴⁶Alizai Naved⁴⁷Huey-Ling Chen⁴⁸Kohli Rohit⁴⁹Wednesday Marie Sevilla⁵⁰Roshawn Watson⁵⁰Fatine Elaraki⁵¹Christelle Baffie⁵⁰Anna Wallebeck⁵²Jennifer Grace⁵²Sofia Ganzha⁵³Anja Vlahovic⁵⁰Piotr Czubkowski⁵⁴, ¹Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, VCU, Richmond, VA, USA,²Guangzhou Women And Childrens Medical Center, Guangzhou, Ghangdong, China,³Beatrix Children’s Hospital/University Medical Center Groningen, Groningen, the Netherlands,⁴Hospital for Sick Children, Toronto, ON, Canada,⁵Children's Hospital of Fudan University, Shanghai, China,⁶Hospital Universitario Vall d'Hebron, Barcelona, Spain,⁷Division of Gastroenterology, Boston Children’s Hospital, Boston, USA,⁸Stanford University School of Medicine/Lucile Packard Children’s Hospital, Palo Alto, CA, USA,⁹University Children’s Hospital Tübingen, Tübingen, Germany,¹⁰Starship Child Health, Te Toka Tumai, Auckland, New Zealand,¹¹Centre Hospitalier Universitaire Sainte-Justine, Montreal, QB, Canada,¹²The Children’s Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA, USA,¹³Pediatric Gastroenterology and Hepatology, Hassenfeld Children’s Hospital, NYU Langone, NY, USA,¹⁴Department of Gastroenterology, Royal Children's Hospital, Melbourne, VIC, Australia,¹⁵Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA,¹⁶University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO, USA,¹⁷Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France,¹⁸The Childrens Hospital at Westmead, Westmead, NSW, Australia,¹⁹Semmelweis University, Department of Pediatrics, Budapest, Hungary,²⁰Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia,²¹Schneider Children’s Medical Center of Israel, Petach Tikva, Israel,²²The Children’s Hospital at Montefiore, Bronx, NY, USA,²³Indiana University/Riley Hospital for Children at IU Health, Indianapolis, IN, USA,²⁴Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA,²⁵Hôpital Bicêtre, AP-HP, Université Paris-Saclay, Hépatinov, Inserm U 1193, Paris, France,²⁶Department of Paediatric Gastroenterology, Akdeniz University, Antalya, Turkey,²⁷Department of Paediatrics, University of Malaya, Malaysia,²⁸Mount Sinai Hospital, NY, USA,²⁹Rady Children's Hospital, San Diego, CA, USA,³⁰Charité Universitätsmedizin Berlin, Berlin, Germany,³¹Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy,³²U.O. di Gastroenterologia ed Epatologia Pediatrica, Padua, Italy,³³Hôpital Universitaire Necker-Enfants Malades, Paris, France,³⁴University Lille, CHU Lille, U 1286 INFINITE, F59000, Lille, France,³⁵Hacettepe University Faculty of Medicine, Ankara, Turkey,³⁶Department of Pediatrics, Children's Mercy–Kansas City, Kansas City, MO, USA,³⁷University of California, San Francisco, CA, USA,³⁸Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA,³⁹Nemours Children's Hospital, Delaware, Wilmington, DE, USA,⁴⁰Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany,⁴¹Azienda Ospedaliera-Città della Salute e della Scienza di Torino, Turin, Italy,⁴²Birmingham Women’s and Children’s Hospital, Birmingham, UK,⁴³The Children's Hospital of Pittsburgh, Pittsburgh, PA, USA,⁴⁴Oregon Health Science University School of Medicine, Portland, OR, USA,⁴⁵Ann & Robert H. Lurie Children's Hospital, Chicago, IL, USA,⁴⁶Cincinnati Children's Hospital, Cincinnati, OH, USA,⁴⁷Leeds General Infirmary, Leeds, UK,⁴⁸National Taiwan University Hospital, Taipei, Taiwan,⁴⁹Childrens Hospital Los Angeles, Los Angeles, CA, USA,⁵⁰Ipsen, Cambridge, MA, USA,⁵¹Ipsen, Boulogne-Billancourt, France,⁵²Albireo, an Ipsen company, Gothenburg, Sweden,⁵³Ipsen, London, UK,⁵⁴Children’s Memorial Health Institute, Warsaw, Poland

4558 | DIFFERENTIAL MODULATION OF BONE MARROW- AND LIVER-DERIVED DENDRITIC CELL FUNCTION BY HEPATIC ISCHEMIA-REPERFUSION- DERIVED EXOSOMES

Cindy Avalos de Leon¹Suguru Mitsufuji¹Alan Zahorchak¹Hamza Yazdani²David Geller²Angus Thomson¹, ¹Thomas E. Starzl Transplantation Institute,²University of Pittsburgh Medical Center

4577 | EXCELLENT OUTCOMES IN PEDIATRIC RECIPIENTS OF ABO-INCOMPATIBLE LIVER TRANSPLANTW: AN ANALYSIS OF THE SPLIT REGISTRY

Sarah Bedoyan¹Bridget Whitehead²James Squires³Sarah Anderson⁴Ravinder Anand⁴Jeff Mitchell⁴Catherine Chapin²The Society of Liver Transplantation⁵, ¹University of Pittsburgh Medical Center,²Ann & Robert H. Lurie Children's Hospital of Chicago,³UPMC Children's Hospital of Pittsburgh,⁴Emmes,⁵n/a

4588 | SPATIAL MOLECULAR IMAGING REVEALS AN EVOLVING INFLAMMATORY INFILTRATE AND PROLIFERATING STEM-LIKE CELLS WITH LIVER DISEASE PROGRESSION IN BILIARY ATRESIA (BA)

Tyler Yasaka¹Mylarappa Ningappa²Chethan Ashokkumar²Stefan Scholz²Simon Horslen²Joseph Glessner³Hakon Hakonarson³Rakesh Sindhi², ¹University of Pittsburgh,²Children's Hospital of Pittsburgh of UPMC, Hillman Center for Pediatric Transplantation,³Center for Applied Genomics (CAG), Children's Hospital of Philadelphia, University of Pennsylvania

4590 | BASILIXIMAB DOSING IN PEDIATRIC LIVER TRANSPLANTATION (LT) RECIPIENTS: STARZL NETWORK EXPERIENCE

Or Steg Saban¹Nadya Nalli¹Evelyn Hsu²Anna Peters³Steven Lobritto⁴Catherine Chapin⁵Frank DiPaola⁶Regino Gonzalez-Peralta⁷Emily Perito⁸James Squires⁹George Mazariegos⁹Vicky Ng¹⁰, ¹The Hospital for Sick Children, Toronto, ON, Canada.,²Seattle Children's and the University of Washington, PO Box 5371/OB.9.640, Seattle, WA 98155, USA.,³Cincinnati Children's Hospital Medical Center,⁴Columbia University Irving Medical Center, New York, NY, USA.,⁵Ann and Robert H. Lurie Children's Hospital of Chicago,⁶University of Virginia, UVA Health Children's Health, Charlottesville, VA.,⁷AdventHealth for Children,⁸University of California, San-Francisco, USA.,⁹Children's Hospital of Pittsburgh,¹⁰Hospital for Sick Children

4607 | PREDICTORS OF BIOCHEMICAL REMISSION FOR PEDIATRIC AUTOIMMUNE HEPATITIS IN NORTH AMERICAN MULTICENTER LEARNING HEALTH NETWORK

Mary Ayers¹Cyd Castro-Rojas²Rebekah Karns²Leina Alrabadi³Heli Bhatt⁴Kate Cheng⁵Ranita Datta⁶Nitika Gupta⁷Jennifer Halma⁸Sakil Kulkarni⁹Shelby Mecklenborg¹⁰Katelyn Saarela¹¹Emily Rothbaum Perito⁵Alexander Weymann¹²Mandy Zhu²James Squires¹³Alexander Miethke²Amy Taylor², ¹UPMC Children's Hospital of Pittsburgh,²Cincinnati Children's Hospital Medical Center,³Stanford/Lucile Packard Childrens Hospital,⁴University of Minnesota Children’s Hospital,⁵University of California, San Francisco,⁶Children's Hospital of Atlanta,⁷Emory University School of Medicine,⁸Children's Mercy Hospital,⁹Washington University in St. Louis,¹⁰University of Cincinnati,¹¹Seattle Children's Hospital,¹²Nationwide Children's Hospital,¹³Children's Hospital of Pittsburgh

Learn more about the American Association for the Study of Liver Diseases (AASLD) 2025 Meeting on The Liver Meeting^® website.