UPMC Children’s Nephrology Team Publishes New Review on Delayed Graft Function After Kidney Transplant

Just published in December 2023 in the American Journal of Physiology – Renal Physiology, a team from UPMC Children’s Hospital of Pittsburgh Division of Pediatric Nephrology have authored a new review article on delayed graft function (DGF) after kidney transplant.

The team included postdoctoral associate Anne C. S. Barbosa, BPharm, PhD; nephrology fellow Lillian G. Mauroner, MD, kidney transplant medical director Juhi Kumar, MD, and division research faculty Sunder Sims-Lucas, PhD.

The main areas covered in the review include DGF risk factors in transplant patients and how these may influence graft survival and longevity, where the science currently is with animal models recapitulating DGF, the current evidence base for treatment strategies, and the state of therapeutic development.

The review was written in light of, and in response to, the increased use of extended criteria donor kidneys as part of the ongoing efforts to bolster the perpetually short supply of needed organs for individuals with end-stage kidney disease.

Extended criteria organs can increase the incidence of DGF, so understanding the current state of the science around the disorder and how to potentially grapple with it clinically and in the lab is a priority for the renal transplant medical community.

Read the full review using the reference link below.

Learn more about the kidney transplantation program at UPMC Children’s

Reference

Barbosa ACS, Mauroner LG, Kumar J, Sims-Lucas S. Delayed Graft Function Post Renal Transplant: A Review on Animal Models and Therapeutics. Am J Physiol Renal Physiol. 2023 Dec 1; 325(6): F817-F825.