The goal of Dr. Lakkis' research is to understand the fundamental mechanisms of acute and chronic rejection in solid organ transplantation. The principal areas of investigation in Dr. Lakkis' laboratory are the innate mechanisms responsible for initiating and perpetuating the alloimmune response and the role of memory T cells in allograft rejection. Dr. Lakkis' laboratory is also part of a human immunology group investigating innate and adaptive immune function in kidney transplant recipients.