Assistant Professor of Medicine

Office:
3500 Terrace Street
BST South, S719
Pittsburgh, PA 15261  
Phone: 412-648-1587Fax: 412-383-8864

Education
BSc, University of Glasgow, Scotland, UK, 2001
PhD, University of Edinburgh, Scotland, UK, 2005
Postdoc, Schering-Plough Biopharma/DNAX, 2009

Area of Specialization/Research Interest  
Autoimmunity and chronic inflammatory disease
Activation and regulation of Th17 cells
IL-23 and other cytokines that modulate inflammation
In vivo modeling of human autoimmune disease such as multiple sclerosis, arthritis, 
colitis  

Profile

The McGeachy lab aims to understand the mechanisms behind inflammatory autoimmune diseases  such as arthritis, multiple sclerosis and colitis. Th17 cells are implicated in driving  these diseases, and the McGeachy lab investigates the mechanisms through which Th17 cells  are activated and regulated, and how these impact disease pathogenesis in various tissues.  We have a particular focus on the functions of the cytokine IL-23 in promoting  Th17-mediated inflammation, as IL-23 has been found to be a key driver of Th17 cells in both mouse models and human disease."