Dr. Schoen is Professor of Medicine and Epidemiology at the University Pittsburgh. His research interests are centered on early detection and prevention of colorectal cancer (CRC). He is a principal investigator in the PLCO cancer screening trial, a randomized trial of over 154,000 individuals which evaluated flexible sigmoidoscopy. He has used PLCO data to study surveillance colonoscopy utilization and yield, interval cancers, or cancers detected shortly after endoscopic procedures, and risk of colorectal cancer among subjects with a family history of cancer.
Dr Schoen is the principal investigator, in collaboration with the Mayo Clinic in Minnesota, of a multicenter randomized immunotherapy trial, evaluating a vaccine for prevention of recurrent adenomatous polyps. He is a principal investigator for the Early Detection Research Network and collaborates with scientists nationally and internationally to identify biomarkers, including circulating tumor DNA and tissue based markers, to detect and monitor cancer. He is an investigator in GECCO, the Genetics and Epidemiology of Colorectal Cancer Consortium, a consortium studying genetic and environmental risk factors for CRC including genome wide association studies and molecular pathologic epidemiology research and modeling of CRC risk using genetic and environmental risk factors.
Dr. Schoen is a co-investigator in a study evaluating colonoscopy quality and is helping to develop a natural language processing tool to evaluate and report on colonoscopy quality in a more efficient manner. In conjunction with that project, Dr. Schoen is developing a database of colonoscopy reports from the last 20 years at UPMC hospitals, for research studies on colonoscopy.