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In this grand rounds presented by the Department of Medicine, Joseph M. Pilewski, MD, explains cystic fibrosis. Dr. Pilewski describes the importance of identifying gene mutations and also reviews the impact of CFTR modulators. 

Educational Objectives 

Upon completion of this activity, participants should be able to:

  • Identify the pathophysiology of lung disease in cystic fibrosis
  • Recognize that cystic fibrosis is an increasingly adult disease with a variety of manifestations
  • Explain new treatment for cystic fibrosis and how those are improving quality of life and survival 
  • Describe how identification of a cellular and genetic defect provides opportunities for targeted therapeutics


Dr. Pilewski has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Vertex, Celtaxys, Translate Bio, Laurent, Cystic Fibrosis Foundation

All presenters' disclosures of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services used on or consumed by patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers, and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website four weeks post-completion at and follow the link to the Credit Transcript page.

Release Date: 7/7/2020 | Last Modified On: 7/7/2020 | Expires: 7/7/2021

This course has been expired.