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Dr. Mark Gladwin provides a brief overview of the state of sickle cell disease, new clinical manifestations of sickle cell disease, and the development of pulmonary hypertension.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Review complications of SCD
  • Discuss prevalence and risk of pulmonary hypertension in adults with SCD
  • Describe evaluation and diagnosis of pulmonary hypertension in patients with SCD

Reading Resources:

  1. Reiter et al. Nature Med 2002.
  2. Simmons et al. Arch Intern Med. 1988;148:1526.
  3. Sutton et al. Am J Cardiol. 1994;74:626.
  4. Castro. Hematol Oncol Clin North Am. 1996;10:1289.
  5. Norris et al. J Assoc Acad Minor Phys. 1992;3:20.
  6. Powars et al. Medicine (Baltimore). 1988;67:66.
  7. Castro et al. Blood. 2003;101:1257.


Dr. Gladwin has financial interests with the following any entity or entities producing health care goods or services as indicated below:  

  • Grant/Research Support: Grants from NIH/NHLBI, grants from Aires Pharmaceuticals, grants and personal fees from Bayer
  • Other: Dr. Gladwin has a patent NIH gov't patent for the use of nitrites for cardiovascular indications with royalties paid and Dr. Gladwin is a co-author on a textbook for medical students published by Medmaster, for which he receives royalties.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to .75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 4/8/2014 | Last Modified On: 7/15/2016 | Expires: 7/17/2017

This course has been expired.