In this issue of Neurosurgery News, Several specialists join
together to discuss topics that included new hope for life after stroke,
leading the way in minimaly invasive management of neurosurgical Diseases,
thirty years of brain gamma knife radiosurgery at UPMC, institutional outcomes
research with endoscopic endonasal approaches for skull base chordoma, upmc
trial of neoadjuvant radiosurgery offers a novel treatment option for
metastatic brain tumors, and EEA for odontoidectomy.
Upon completion of this activity, participants should be
- Improve patient outcomes by implementing the use of a new surgical tool designed to better manage intracranial hemorrhage.
- Improve the management of intracranial hemorrhage by understanding the limitations of past trials
- Learn the common and current uses of radiosurgery and review the history of Gamma Knife radiosurgery at UPMC
- Describe the gross total resection rates for chordomas
- Describe the importance of the degree of resection for progression free survival
- Follow recommended protocols regarding the necessity of radiation therapy and/or Radiosurgery in the treatment of brain metastasis
- Recognize the challenges of adjuvant radiosurgery after resection of a brain metastasis.
- Explain neo-adjuvant therapy within clinical practice and cancer care.
- Recognize potential complications of transoral odontoidectomy, including the benefits of endoscopic endonasal resection of the odontoid.
- Review the largest series of endoscopic endonasal odontoidectomy, and recognize the potential complications and benefits of the endoscopic endonasal approach for odontoidectomy.
- Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A,
Mitchell PM; STICH II Investigators..Lancet. 2013 Aug 3;382(9890):397-408.
- Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale
GM, Hope DT, Karimi A, Shaw MD, Barer DH; STICH investigators.Lancet. 2005 Jan
- Hanley DF, Thompson RE, Muschelli J, Rosenblum M, McBee N,
Lane K, Bistran-Hall AJ, Mayo SW, Keyl P, Gandhi D, Morgan TC, Ullman N, Mould
WA, Carhuapoma JR, Kase C, Ziai W, Thompson CB, Yenokyan G, Huang E, Broaddus
WC, Graham RS, Aldrich EF, Dodd R, Wijman C, Caron JL, Huang J, Camarata P,
Mendelow AD, Gregson B, Janis S, Vespa P, Martin N, Awad I, Zuccarello M;
MISTIE Investigators. Lancet Neurol. 2016 Nov;15(12):1228-1237
EA, Grandhi R, Niranjan A, Lunsford LD. The past, present and future of Gamma
Knife radiosurgery for brain tumors: the Pittsburgh experience. Expert Rev
A, Lunsford LD. Gamma Knife Radiosurgery for 5 to 10 Brain Metastases: A Good
Option for Upfront Treatment. Oncology 2016;30.
- Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka
D. Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
Journal of neurosurgery 2005;102 Suppl:195-9.
- Fernandez-Miranda JC, Gardner PA, Snyderman CH, Devaney KO,
Mendenhall WM, Suárez C, Rinaldo A, Ferlito A. Clival chordomas: A
pathological, surgical, and radiotherapeutic review. Head Neck. 2014
Jun;36(6):892-906. doi: 10.1002/hed.23415. Epub 2013 Oct 4. Review. PubMed
- Koutourousiou M, Gardner PA, Tormenti MJ, Henry SL, Stefko
ST, Kassam AB, Fernandez-Miranda JC, Snyderman CH. Endoscopic endonasal
approach for resection of cranial base chordomas: outcomes and learning curve.
Neurosurgery. 2012 Sep;71(3):614-24; discussion 624-5. doi:
10.1227/NEU.0b013e31825ea3e0. PubMed PMID: 22592328.
- Koutourousiou M, Snyderman CH, Fernandez-Miranda J, Gardner
PA. Skull base chordomas. Otolaryngol Clin North Am. 2011 Oct;44(5):1155-71.
doi: 10.1016/j.otc.2011.06.002. Epub 2011 Jul 21. Review. PubMed PMID:
- Rao G, Ahmed S, Hess K, Mahajan A. Postoperative
stereotactic radiosurgery vs. observation for completely resected brain metastases:
results of a prospective randomized study. Neurosurgery 2016 Aug;63 Suppl
- Luther N, Kondziolka D, Kano H, et al. Predicting tumor
control after resection bed radiosurgery of brain metastases. Neurosurgery 2013
- Patel KR, Burri SH, Boselli D, et al. Comparing
pre-operative stereotactic radiosurgery (SRS) to post-operative whole brain
radiation therapy (WBRT) for resectable brain metastases: a multi-institutional
analysis. J Neurooncol 2017 Feb;131(3):611-618.
- Zwagerman NT, Tormenti MJ, Tempel ZJ, Wang EW, Snyderman CH,
Fernandez-Miranda JC, Gardner PA. Endoscopic endonasal resection of the
odontoid process: clinical outcomes in 34 adults. J Neurosurg. 2017 May 12:1-9.
- Tubbs RS, Demerdash A, Rizk E, Chapman JR, Oskouian RJ.
Complications of transoral and transnasal odontoidectomy: a comprehensive
review. Childs Nerv Syst. 2016 Jan;32(1):55-9. doi: 10.1007/s00381-015-2864-6.
Epub 2015 Aug 7. Review
- Re M, Iacoangeli M, Di Somma L, Alvaro L, Nasi D, Magliulo
G, Gioacchini FM, Fradeani D, Scerrati M. Endoscopic endonasal approach to the
craniocervical junction: the importance of anterior C1 arch preservation or its
reconstruction. Acta Otorhinolaryngol Ital. 2016 Apr;36(2):107-18. doi:
10.14639/0392-100X-647. Epub 2016 Apr 29.
Drs. Jankowitz, Niranjan, Zenonos, Gardner, Engh, Zwagerman, and Fernandez-Miranda have
reported no relevant relationships with any entities producing health care
goods or services.
Dr. L. Dade Lunsford has financial interests with the
following any entity or entities producing health care goods or
services as indicated below:
- Consultant: Insightec, DSMB
- Stockholder: Eleckta
All presenters disclosure of relevant financial
relationships with any entity producing, marketing, re-selling, or distributing
health care goods or services, used on, or consumed by, patients is listed
above. No other planners, members of the planning committee, speakers,
presenters, authors, content reviewers and/or anyone else in a position to
control the content of this education activity have relevant financial
relationships to disclose.
The University of Pittsburgh School of Medicine is
accredited by the Accreditation Council for Continuing Medical Education
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The University of Pittsburgh School of Medicine designates
this enduring material for a maximum of .5 AMA PRA Category 1
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Release Date: 8/22/2017 | Last Modified On: 8/22/2017 | Expires: 8/22/2018